Effect of drug-to-lipid ratio on nanodisc-based tenofovir drug delivery to the brain for HIV-1 infection

Background: Combination antiretroviral therapy has significantly advanced HIV-1 infection treatment. However, HIV-1 remains persistent in the brain; the inaccessibility of the blood–brain barrier allows for persistent HIV-1 infections and neuroinflammation. Nanotechnology-based drug carriers such as nanodiscoidal bicelles can provide a solution to combat this challenge. Methods: This study investigated the safety and extended release of a combination antiretroviral therapy drug (tenofovir)-loaded nanodiscs for HIV-1 treatment in the brain both in vitro and in vivo. Result: The nanodiscs entrapped the drug in their interior hydrophobic core and released the payload at the desired location and in a controlled release pattern. The study also included a comparative pharmacokinetic analysis of nanodisc formulations in in vitro and in vivo models. Conclusion: The study provides potential applications of nanodiscs for HIV-1 therapy development

Stock assessment of seerfishes in the Indian seas

The annual average catch of seerfishes from the Indian seas was 45,0601 during 1995-'99, which constituted 1.8% of the total marine fish catch in India. State-wise Gujarat (28.5%) was the major producer followed by Tamilnadu (15.8%), Maharashtra (15.4%), Andhra Pradesh (11.4%) and Kerala (10.5%). Gill net is the dominant gear in exploiting seerfish followed by trawl, hooks & line, boat seines, shore seines and purse seines. Among the five species, the kingseer Scomberomorus commerson (59.0%) and the spotted seer S. guttatus (35.1%) sustained the fishery, while the streaked seer S.lineolatus and the wahoo Acanthocybium solandri formed only a negligible portion of the fisher

CMFRI Marine Fisheries Policy Series No-6; Non-Detriment Findings (NDF) for the export of Shark and Ray species listed in Appendix II of the CITES and harvested from Indian waters

This document entitled “Guidance on National Plan of Action for Sharks in India” is intended as a guidance to the NPOA-Sharks, and seeks to (1) present an overview of the current status of India’s shark fishery, (2) assess the current management measures and their effectiveness, (3) identify the knowledge gaps that need to be addressed in NPOA-Sharks and (4) suggest a theme-based action plan for NPOA-Sharks

Status of exploitation of seerfishes in the Indian seas

Seerfish production from the Indian seas during the past five decades from 1950s to 1990s, showed an increasing trend. The annual catch increased from 4,505 t in 1953 to 54,8761 in 1998. The average annual catch during the five decadal periods k-aried from 7,278 t in 1950-'59 to 41,575 t in 1990-'99 contributing 1.5% and 1.75% respectively to the total marine fish catch of India. However, the rate of increase through the successive decades decreased indicating the attainment of op- ;imum level of production currently. During 1950-'59, the east coast contributed more (60%) than the west coast (40%), which changed to 36:64 during 1990-'99. iVmong the maritime states of India, Gujarat (25.88%), Maharashtra (16.09%), familnadu (13.59%), Kerala (13.07%) and Andhra Pradesh (12.68%) were the prime seerfish producers during 1990-'99. Gill net (64.8%) was the dominant gear, folowed by trawl (17.4%) and hooks and line (4%) with an average catch rate of 8.1 <g/unit, 0.24 kg/hr and 3.7 kg/unit respectively during 1995-'99. Among the five species, the fishery was sustained only by two species viz., the king seer Scomberomorus commerson and the spotted seer S.guttatus

Minimum Legal Size proposed for commercially exploited marine finfish and shellfish resources of Tamil Nadu

Marine fisheries in Tamil Nadu have undergone tremendous change in terms of fishing pattern, fishing method, extension of fishing grounds, composition of fish catch and consequent increase in the total fish catch in recent years. The recent demand from industries involved in fish meal and fish oil encourages targeted fishing for by-catch resulting in heavy landing of low value by-catch in certain places along Tamil Nadu coast. These by-catch are often dominated by juveniles of many commercially important marine finfishes and shell fishes. So it warrants some caution and intervention. One of the methods to discourage the indiscriminate exploitation of juveniles is to impose a Minimum Legal Size (MLS) which is the size at which a particular species can be legally retained if caught. The advantage of a MLS is that it aids in the control of two major problems in the fisheries management, growth overfishing and recruitment overfishing either by increasing the minimum size of harvest or by increasing or maintaining the size of the spawning stock. The most common method of increasing the reproductive output through the use of size limits is to set the minimum size at which the females become sexually mature. As the individuals of a species do not attain sexual maturity at the same size, it can be a size at which higher proportions are mature

Status of exploitation of coastal tunas in the Indian seas

Tuna and billfish production from Indian seas during the period 1985-'99 evinced an increasing trend and the landings fluctuated between 24,287 t (1987) and 53,6621 (1992). The average annual production during the said period was 40,2041, contributing to 3.6% of the total pelagic fish landings and 1.8% of the total marine fish landings. On an average, 24% of the total tuna and billfish production during 1991-'99 was contributed by northwest coast, 2% by Andaman and Nicobar islands and 14.9% by Lakshadweep. Among the maritime states, Kerala (36 %), Gujarat (18.1%) Tamilnadu (11.6%), Maharashtra (5.9%), Kamataka (5%), Andhra Pradesh (4.4 %) and Goa (2%) were the prime tuna producing states

Stock assessment of coastal tunas in the Indian seas

Tuna and billfish production from the Indian coastal waters, Lakshadweep and Andaman and Nicobar islands during the period 1985-'99 averaged 40,204 t. The contribution by E.affinis, Athazard, T.tonggol, K.pelamis and T.albacares (young ones) were 18,5041,6,8521,3,093 t, 3,3921 and 2,2111 respectively. Drift gill net was the major gear employed in the coastal tuna fishery. The length frequency data collected on the above species during 1990-'98 at seven centres along the Indian coast were analysed employing FiSAT programme to estimate their growth and mortality parameters, exploitation rates and relative yield per recmit

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