1 research outputs found
Graphene@Poly(phenylboronic acid)s Microgels with Selectively Glucose-Responsive Volume Phase Transition Behavior at a Physiological pH
The
selective response to glucose is possible by using a poly(phenylboronic
acid) microgel under a rational design. Such a microgel is made of
graphene covalently immobilized in a microgel of poly(4-vinylphenylboronic
acid) cross-linked with <i>N</i>,<i>N</i>′-methylenebis(acrylamide).
Unlike the microgels reported in previous arts that would undergo
volume phase transition in response to both glucose and other monosaccharides,
the proposed microgels shrink upon adding glucose, whereas keep unchanged
in the size upon adding other monosaccharides (with fructose, galactose,
and mannose as models). Although the polysaccharides/glycoproteins
(with dextran and Ribonuclease B as models) that contain many glycosyl
residues can slightly absorb on the microgel surface and lead to a
small impact on glucose-response, it can be addressed by further coating
the microgel as a core with a thin nonglucose-responsive poly(<i>N</i>-isopropylacrylamide) gel shell. This selectively glucose-responsive
volume phase transition behavior enables “turn-on” photoluminescence
detection of glucose in blood serum (a model for complex biosystems)