3 research outputs found
A DielsāAlder-Based Total Synthesis of (ā)-Kainic Acid
An efficient synthesis of (ā)-kainic acid, through
a high-pressure-promoted
DielsāAlder cycloaddition of a vinylogous malonate derived
from 4-hydroxyproline, is described. The bicyclic adduct could be
converted into the natural product with complete stereocontrol
First Donor-Stabilized Complexes of Manganese(II) with Disubstituted diphenyldithiophosphates: synthesis, characterization, biological, and X-ray Analysis
<div><p>GRAPHICAL ABSTRACT</p><p></p></div
Aggregation of Donor Base Stabilized 2-Thienyllithium in a Single Crystal and in Solution: Distances from X-ray Diffraction and the Nuclear Overhauser Effect
Various 2-thienyllithium derivatives were investigated
in the solid
state by X-ray diffraction and in solution by 2D NMR experiments.
The determined structures of [(Et<sub>2</sub>O)ĀLiĀ(C<sub>4</sub>H<sub>3</sub>S)]<sub>4</sub> (<b>1</b>), [(THF)<sub>2</sub>LiĀ(C<sub>4</sub>H<sub>3</sub>S)]<sub>2</sub> (<b>2</b>), [(DME)ĀLiĀ(C<sub>4</sub>H<sub>3</sub>S)]<sub>2</sub> (<b>3</b>), [(TMEDA)ĀLiĀ(C<sub>4</sub>H<sub>3</sub>S)]<sub>2</sub> (<b>4</b>), and [(PMDETA)ĀLiĀ(C<sub>4</sub>H<sub>3</sub>S)] (<b>5</b>) (DME = 1,2-dimethoxyethane,
TMEDA = <i>N</i>,<i>N</i>,<i>N</i>ā²,<i>N</i>ā²-tetramethylethylene-1,2-diamine, and PMDETA = <i>N</i>,<i>N</i>,<i>N</i>ā²,<i>N</i>ā³,<i>N</i>ā³-pentamethyldiethylenetriamine)
were solved in nondonating toluene and provide firm ground for diffusion-ordered
NMR spectroscopy as well as heteronuclear Overhauser enhancement NMR
spectroscopy. The distance relation of nuclear Overhauser effects
with a factor of <i>r</i><sup>ā6</sup> is employed
to gain further insight into the aggregation degree of <b>1</b>ā<b>5</b> in solution. Comparison of the slope provided
by the linear region of the buildup curves and of the ā<i>r</i><sup>ā6</sup> calculated distances from the crystal
structures offers a handle to judge the structure retention versus
conversion in solution. The structures of <b>3</b>ā<b>5</b> are maintained in toluene solution. The data of <b>2</b>, however, indicate a partial dissociation or a rapid exchange between
the vertices of a tetrameric core and free THF molecules. Auxiliary
exchange spectroscopy investigations showed that the signals of the
nitrogen donor base containing compounds <b>4</b> and <b>5</b> exchange with the signals of nonlithiated thiophene. This
is explained by exchange of the deuterium by a hydrogen atom via lithiation
of toluene molecules