Additional file 5: of Integrated genome-wide Alu methylation and transcriptome profiling analyses reveal novel epigenetic regulatory networks associated with autism spectrum disorder

Correlation analysis between AluS methylation and expression level of ASD subgroup L. (PDF 329 kb

Schematic diagram of the experimental workflow of this study.

<p>Schematic diagram of the experimental workflow of this study.</p

Correlation analysis of LINE-1 methylation and expression in ASD individuals with severe language deficits and sex-/age-matched controls.

<p>The X-axis represents the percentage of LINE-1 methylation. The Y-axis represents the log₂ fold change of LINE-1 expression against <i>GAPDH</i>. R² and P-values were calculated via Spearman’s correlation method.</p

Additional file 3: of Integrated genome-wide Alu methylation and transcriptome profiling analyses reveal novel epigenetic regulatory networks associated with autism spectrum disorder

List of the overlapping genes. (DOC 118 kb

Canonical pathways significantly associated with dysregulated genes with LINE-1 insertion predicted by the Ingenuity Pathway Analysis (IPA).

<p>Canonical pathways significantly associated with dysregulated genes with LINE-1 insertion predicted by the Ingenuity Pathway Analysis (IPA).</p

Additional file 2: of Integrated genome-wide Alu methylation and transcriptome profiling analyses reveal novel epigenetic regulatory networks associated with autism spectrum disorder

Association analysis between the DEGs in ASD from GSE15402 and the human Alu-inserted genes lists when ASD individuals were sub-grouped based on ADI-R scores. The comparisons were performed for five types of Alu insertions, including exonized, exonic, intronic, promoter and all types. The Fisher’s exact test P value and number of DEGs are shown. (DOC 46 kb

Additional file 6: of Integrated genome-wide Alu methylation and transcriptome profiling analyses reveal novel epigenetic regulatory networks associated with autism spectrum disorder

Correlation analysis between AluS methylation and expression level of ASD subgroup S. (PDF 333 kb

The details of the transcriptome profiles obtained from NCBI GEO DataSets database.

<p>The details of the transcriptome profiles obtained from NCBI GEO DataSets database.</p

Additional file 1: of Integrated genome-wide Alu methylation and transcriptome profiling analyses reveal novel epigenetic regulatory networks associated with autism spectrum disorder

Demographic information of LCLs used in this study. (DOC 73 kb

Developmental and neurological diseases significantly associated with dysregulated genes with LINE-1 insertion predicted via IPA.

<p>Developmental and neurological diseases significantly associated with dysregulated genes with LINE-1 insertion predicted via IPA.</p