Public Housing of Early Modern Tianjin (1928-1937)

Societal reform, the planning and construction of public housing and the introduction of new building typologies went hand in hand in early modern China. Western and Japanese debates on public housing served as models, and Chinese scholars and professionals with the support of the KMT (Kuomintang) developed public housing as a sign of innovation both in terms of societal organization and building typology. Using the under-researched case of Tianjin’s public housing in the so-called Golden Decade (1928 -1937) as a case study, the paper first explores how journals and foreign trained Chinese scholars introduced the concept of modern housing to China through publications, and early constructions. Notably the YMCA Labours Model New Village in Shanghai impressed the KMT leader Chiang Kai-shek. It then explores three public housing projects developed for Tianjin, only one of which was realized. Exploring the locations, architectural designs, renting regulations and management rules of these projects, the paper argues that these projects (both planned and realized) aimed mostly at poor families, and served as a means to solve housing problems and reform society as well as to police the poor. The public housing projects in this period formed the foundation for later public housing in China

Historical analysis of urban public transportation development in modern Tianjin (1902-1949)

Tianjin was the earliest city opening urban public transport lines in China. Urban public transportation had profound impacts on urban construction and on the formation of urban structure in Tianjin from 1902 to 1949. Based on the background of urban development, this paper firstly divides the evolution process of public transportation represented by tramways and buses into three periods from the perspectives of the distribution, quantity and operation status of public transportation lines. It then analyses the strong influence of public transportation on urban roads construction from the view of the increased municipal income, road widening, improvement of pavement quality, and bridges construction and maintenance. Finally, by using qualitative and quantitative analysis and superposing the related statistical data with the historical map, it analyses the relationship among public transportation line density, land value partition and basic urban structure, and certifies they were highly relative. In conclusion, the paper argues that Tianjin urban public transport network was based on trams and supplemented by buses, and not only planning ideas but also advanced municipal technologies from the West like public transportation system were also indispensable supports in the process of urban modernization in Chinese modern treaty ports

SISSA: Real-time Monitoring of Hardware Functional Safety and Cybersecurity with In-vehicle SOME/IP Ethernet Traffic

Scalable service-Oriented Middleware over IP (SOME/IP) is an Ethernet communication standard protocol in the Automotive Open System Architecture (AUTOSAR), promoting ECU-to-ECU communication over the IP stack. However, SOME/IP lacks a robust security architecture, making it susceptible to potential attacks. Besides, random hardware failure of ECU will disrupt SOME/IP communication. In this paper, we propose SISSA, a SOME/IP communication traffic-based approach for modeling and analyzing in-vehicle functional safety and cyber security. Specifically, SISSA models hardware failures with the Weibull distribution and addresses five potential attacks on SOME/IP communication, including Distributed Denial-of-Services, Man-in-the-Middle, and abnormal communication processes, assuming a malicious user accesses the in-vehicle network. Subsequently, SISSA designs a series of deep learning models with various backbones to extract features from SOME/IP sessions among ECUs. We adopt residual self-attention to accelerate the model's convergence and enhance detection accuracy, determining whether an ECU is under attack, facing functional failure, or operating normally. Additionally, we have created and annotated a dataset encompassing various classes, including indicators of attack, functionality, and normalcy. This contribution is noteworthy due to the scarcity of publicly accessible datasets with such characteristics.Extensive experimental results show the effectiveness and efficiency of SISSA

Bibliometric analysis of kinship analysis from 1960 to 2023: global trends and development

Kinship analysis is a crucial aspect of forensic genetics. This study analyzed 1,222 publications on kinship analysis from 1960 to 2023 using bibliometric analysis techniques, investigating the annual publication and citation patterns, most productive countries, organizations, authors and journals, most cited documents and co-occurrence of keywords. The initial publication in this field occurred in 1960. Since 2007, there has been a significant increase in publications, with over 30 published annually except for 2010. China had the most publications (n = 213, 17.43%), followed by the United States (n = 175, 14.32%) and Germany (n = 89, 7.28%). The United States also had the highest citation count. Sichuan University in China has the largest number of published articles. The University of Leipzig and the University of Cologne in Germany exhibit the highest total citation count and average citation, respectively. Budowle B was the most prolific author and Kayser M was the most cited author. In terms of publications, Forensic Science International-Genetics, Forensic Science International, and International Journal of Legal Medicine were the most prolific journals. Among them, Forensic Science International-Genetics boasted the highest h-index, citation count, and average citation rate. The most frequently cited publication was “Van Oven M, 2009, Hum Mutat”, with a total of 1,361 citations. The most frequent co-occurrence keyword included “DNA”, “Loci”, “Paternity testing”, “Population”, “Markers”, and “Identification”, with recent interest focusing on “Kinship analysis”, “SNP” and “Inference”. The current research is centered around microhaplotypes, forensic genetic genealogy, and massively parallel sequencing. The field advanced with new DNA analysis methods, tools, and genetic markers. Collaborative research among nations, organizations, and authors benefits idea exchange, problem-solving efficiency, and high-quality results

KIN10 promotes stomatal development through stabilization of the SPEECHLESS transcription factor

Stomata are epidermal structures that modulate gas exchanges between plants and the atmosphere. The formation of stomata is regulated by multiple developmental and environmental signals, but how these signals are coordinated to control this process remains unclear. Here, we showed that the conserved energy sensor kinase SnRK1 promotes stomatal development under short-day photoperiod or in liquid culture conditions. Mutation of KIN10, the catalytic α-subunit of SnRK1, results in the decreased stomatal index; while overexpression of KIN10 significantly induces stomatal development. KIN10 displays the cell-type-specific subcellular location pattern. The nuclear-localized KIN10 proteins are highly enriched in the stomatal lineage cells to phosphorylate and stabilize SPEECHLESS, a master regulator of stomatal formation, thereby promoting stomatal development. Our work identifies a module links connecting the energy signaling and stomatal development and reveals that multiple regulatory mechanisms are in place for SnRK1 to modulate stomatal development in response to changing environments

Extensive necrotizing fasciitis of scrotum and abdominal wall: Report of two cases and a review of the literature

The incidence rate of necrotizing fasciitis(NF) is low, but it has a high mortality rate. At present, it lacks experience in clinical treatment in municipal and county-level hospitals, insufficient awareness of disease risk, lack of experience in disease surgical intervention, and lack of a set of mature treatment norms and standards. Most patients have no time to transfer to a higher hospital for treatment. In January and April 2022, two cases of large-scale necrotizing fasciitis of the scrotum and abdominal wall were treated in the Department of Urology of Weifang people's Hospital respectively and were clinically cured after active surgical debridement combined with broad-spectrum antibiotics. Through the retrospective analysis of the diagnosis and treatment of two cases of necrotizing fasciitis, this paper analyzes and summarizes the scope of surgical debridement of NF, postoperative dressing changing skills, timing of multiple debridements, application and timing of vacuum sealing drainage(VSD), and the combined use of antibiotics. To provide experience for clinical diagnosis and treatment of necrotizing fasciitis

The Role of Osteopontin and Its Gene on Glucocorticoid Response in Myasthenia Gravis

Biomarkers that assess treatment response for patients with the autoimmune disorder, myasthenia gravis (MG), have not been evaluated to a significant extent. We hypothesized the pro-inflammatory cytokine, osteopontin (OPN), may be associated with variability of response to glucocorticoids (GCs) in patients with MG. A cohort of 250 MG patients treated with standardized protocol of GCs was recruited, and plasma OPN and polymorphisms of its gene, secreted phosphoprotein 1 (SPP1), were evaluated. Mean OPN levels were higher in patients compared to healthy controls. Carriers of rs11728697*T allele (allele definition: one of two or more alternative forms of a gene) were more frequent in the poorly GC responsive group compared to the GC responsive group indicating an association of rs11728697*T allele with GC non-responsiveness. One risk haplotype (AGTACT) was identified associated with GC non-responsiveness compared with GC responsive MG group. Genetic variations of SPP1 were found associated with the response to GC among MG patients

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

ABIOTIC AND BIOTIC DEGRADATION OF BISPHENOLS

Bisphenol A (BPA), as well as its substitutes bisphenol S (BPS) and bisphenol AF (BPAF), are high production volume chemicals and potential endocrine disruptors. The oxidized manganese (Mn) species, soluble Mn(III) and solid Mn(IV) (i.e., MnO2), are typically generated in Mn-cycling driven by Mn-oxidizing bacteria and Mn-reducing bacteria. MnO2 is a strong oxidant capable of oxidizing a variety of organic contaminants including bisphenols. Soluble Mn(III) commonly occurs near oxic-anoxic interfaces and is an important environmental oxidant. Mn(III) is also associated with both biogenic and synthesized MnO2. However, the effect of Mn(III) on the degradation of bisphenols is lacking. Mn-oxidizing bacteria effectively remove BPA through enzymatic reactions, which may also be capable of transforming BPA substitutes. Therefore, the present study conducted a series of experiments to demonstrate how Mn-cycling affects the fate of bisphenols. In addition, soluble Mn(III) was demonstrated to mediate BPA degradation. Mn(III) affected the reactivity of MnO2 thereby affecting BPA degradation. Comparative studies of MnO2- versus Mn(III)-mediated BPA degradation revealed the formation of distinct transformation products and mechanistic differences. Notably, soluble Mn(III), but not solid MnO2, degraded adsorbed BPA, and small-angle neutron scattering experiments revealed that both adsorption and degradation of adsorbed BPA occurred in solid matrix pores. Erythrobacter sp. strain SD21, an Mn-oxidizing bacterium, effectively transformed BPA, and the BPA substitutes BPS and BPAF, in the absence of Mn. Hydroxylated bisphenol transformation products were detected, suggesting that hydroxylation is the initial step for bisphenol transformation. Genomic analysis of strain SD21 identified genes encoding monooxygenases and the inhibition experiment suggested that a monooxygenase was involved in the transformation of BPA, BPS, and BPAF. The findings demonstrate that the fate of bisphenols is closely related to Mn-cycling, with crucial roles of Mn(II)-oxidizing microorganisms implicated in the formation of oxidized Mn species. Active Mn-cycling occurs near oxic-anoxic transition zones and the observation that bisphenols are susceptible to degradation/transformation by oxidized Mn species and Mn(II)-oxidizing bacteria has implications for predicting, and possibly managing, the fate and longevity of bisphenols in environmental systems