2 research outputs found
Direct β‑C(sp<sup>3</sup>)–H Functionalization of Aliphatic Amines to α,β-Unsaturated Imines, Aldehydes, and Chromenes
A metal-free
method for direct β-CÂ(sp<sup>3</sup>)–H
functionalization of aliphatic amine was developed. The method is
based on a reaction that yields enamine directly from the corresponding
aliphatic amine, which otherwise requires the aid of metallic reagent
and/or external oxidant. The reaction is operationally simple, general,
and highly efficient in functionalizing both cyclic and acyclic amines.
Structurally diverse unsaturated imines were obtained from <i>N</i>-heterocycles, while acyclic amines provided 2-alkyl cinnamaldehyde
and benzopyran derivatives with excellent <i>E</i>/<i>Z</i>-selectivity
Direct β‑C(sp<sup>3</sup>)–H Functionalization of Aliphatic Amines to α,β-Unsaturated Imines, Aldehydes, and Chromenes
A metal-free
method for direct β-CÂ(sp<sup>3</sup>)–H
functionalization of aliphatic amine was developed. The method is
based on a reaction that yields enamine directly from the corresponding
aliphatic amine, which otherwise requires the aid of metallic reagent
and/or external oxidant. The reaction is operationally simple, general,
and highly efficient in functionalizing both cyclic and acyclic amines.
Structurally diverse unsaturated imines were obtained from <i>N</i>-heterocycles, while acyclic amines provided 2-alkyl cinnamaldehyde
and benzopyran derivatives with excellent <i>E</i>/<i>Z</i>-selectivity