Clinical characteristics according to visceral adiposity (VAT/SAT ratio) and fitness level (recovery heart rate).

<p>Abbreviations: VAT/SAT ratio, visceral adipose tissue area to subcutaneous adipose tissue area ratio; BMI, Body Mass Index; BP, Blood pressure; MET-h/wk, metabolic equivalents hour per week; LDL, low-density lipoprotein; HDL, high-density lipoprotein; HOMA-IR, Homeostasis model assessment of insulin resistance; hsCRP, high sensitive C-reactive protein.</p><p>^a p-values are calculated by ANOVA with Bonferroni method.</p><p>p<0.05 vs. Low visceral adiposity high fitness level; ^†p<0.05 vs. Low visceral adiposity low fitness level; ^‡p<0.05 vs. High visceral adiposity high fitness level; ^§p<0.05 vs. High visceral adiposity low fitness level Variables are expressed as mean±SD for continuous variables or number (%) for categorical variables.</p

Odds ratio for metabolic syndrome according to visceral adiposity(VAT/SAT ratio) and fitness level(recovery heart rate).

<p>Adjusted odds ratio: adjusted for age, sex, smoking, alcohol, physical activity status, and body mass index. *p< 0.05, **p<0.01, calculated by multiple logistic regression analyses.</p

Weight change and risk of uterine leiomyomas: Korea Nurses’ Health Study

<p><b>Objective:</b> This study examined the associations between anthropometric measures and uterine leiomyomas.</p> <p><b>Methods:</b> This study included a total of 5,062 women (median age of 35.5 years) who had experienced pregnancy and, of these women, 210 reported a diagnosis of uterine leiomyomas within the past 2 years prior to baseline in the Korea Nurses’ Health Study. Participants were asked about their anthropometric factors. The odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using logistic regression models.</p> <p><b>Results:</b> Mean body mass index (BMI) was 21.8 kg/m² among non-cases. An increase in weight from the age of 18 years to the present was associated with increased risk of uterine leiomyomas (<i>p</i> for trend = .002); compared to women whose weight remained stable, the multivariate ORs (95% CIs) were 1.84 (1.22–2.76) for weight gain of 5–10 kg and 2.00 (1.25–3.20) for weight gain of more than 10 kg since age 18. A similar pattern was observed when the analysis was limited to women with a BMI of 18.5–25 kg/m². Current weight was associated with higher odds of uterine leiomyomas. No associations were found for body size in childhood or in adolescence, weight at age 18, current BMI, or current body size.</p> <p><b>Conclusions:</b> Weight gain in adulthood was associated with increased risk of uterine leiomyomas in Korean women, even in those with normal weight.</p

Table1_ACCESS: an empirically-based framework developed by the International Nursing CASCADE Consortium to address genomic disparities through the nursing workforce.docx

Introduction: Efforts are needed across disciplines to close disparities in genomic healthcare. Nurses are the most numerous trained healthcare professionals worldwide and can play a key role in addressing disparities across the continuum of care. ACCESS is an empirically-based theoretical framework to guide clinical practice in order to ameliorate genomic disparities.Methods: The framework was developed by the International Nursing CASCADE Consortium based on evidence collected between 2005 and 2023 from individuals and families of various ethnic backgrounds, with diverse hereditary conditions, and in different healthcare systems, i.e., Israel, Korea, Switzerland, and several U.S. States. The components of the framework were validated against published scientific literature.Results: ACCESS stands for Advocating, Coping, Communication, cascadE Screening, and Surveillance. Each component is demonstrated in concrete examples of clinical practice within the scope of the nursing profession related to genomic healthcare. Key outcomes include advocacy, active coping, intrafamilial communication, cascade screening, and lifelong surveillance. Advocacy entails timely identification of at-risk individuals, facilitating referrals to specialized services, and informed decision-making for testing. Active coping enhances lifelong adaptation and management of disease risk. Effective intrafamilial communication of predisposition to hereditary disease supports cascade testing of unaffected at-risk relatives. Lifelong surveillance is essential for identifying recurrence, changes in health status, and disease trajectory for life-threatening and for life-altering conditions.Discussion: ACCESS provides a standardized, systematic, situational, and unifying guide to practice and is applicable for nursing and for other healthcare professions. When appropriately enacted it will contribute towards equitable access to genomic resources and services.</p