2 research outputs found
Technological development and stability study of chewable tablets of Calcium and Magnesium Citrate
No full textEl desarrollo de suplementos nutricionales en forma s贸lida (tabletas, c谩psulas y granulados) a partir de fuentes naturales, resulta un 谩rea de constante inter茅s en la investigaci贸n del farmac茅utico, con la finalidad de lograr un sistema estable que cuente con actividad biol贸gica. Con esta proyecci贸n se dise帽贸 una formulaci贸n de citrato de calcio y magnesio en forma de tabletas masticables. Para ello se elaboraron diferentes ensayos tecnol贸gicos resultando la formulaci贸n C la que rindiera mejores propiedades f铆sicomec谩nicas y tecnol贸gicas, as铆 como una adecuada apariencia superficial; por lo que la seleccionamos como mejor variante tecnol贸gica. De dicha formulaci贸n se derivaron granulados y tabletas con satisfactorias propiedades organol茅pticas, f铆sico-mec谩nicas y tecnol贸gicas. Los lotes de estabilidad fueron elaborados a escala piloto, demostrando la factibilidad del proceso de fabricaci贸n a esta escala. Las tabletas se envasaron en frascos pl谩sticos de polietileno de baja densidad. La estabilidad qu铆mica y microbiol贸gica del producto terminado fue estudiada durante 36 meses y los resultados demostraron la buena estabilidad del mismo.The development of nutritional supplements in solid form (tablets, capsules and granulated) starting from natural sources, is an area of constant interest in the pharmacist's investigation, with the purpose of achieving a stable system that has biological activity. With this projection it was designed a formulation of calcium and magnesium mitrate in form of chewables tablets. For this different technological assays were elaborated, being the formulation C the one that surrendered better physical-mechanical and technological properties, as well as an appropriate superficial appearance, and then was selected as the better technological variant. From this formulation were derived granulated and tablets with satisfactory organoleptic, physical-mechanical and technological properties. The stability lots were elaborated to pilot scale, demonstrating the feasibility from the process of production at this scale. The tablets were packed in plastic bottles of low-density polyethylene. The chemical and microbiological stability of the finished product was studied during 36 months, and the results demonstrated the good stability of it.Colegio de Farmac茅uticos de la Provincia de Buenos Aire
Technological development and stability study of chewable tablets of Calcium and Magnesium Citrate
No full textEl desarrollo de suplementos nutricionales en forma s贸lida (tabletas, c谩psulas y granulados) a partir de fuentes naturales, resulta un 谩rea de constante inter茅s en la investigaci贸n del farmac茅utico, con la finalidad de lograr un sistema estable que cuente con actividad biol贸gica. Con esta proyecci贸n se dise帽贸 una formulaci贸n de citrato de calcio y magnesio en forma de tabletas masticables. Para ello se elaboraron diferentes ensayos tecnol贸gicos resultando la formulaci贸n C la que rindiera mejores propiedades f铆sicomec谩nicas y tecnol贸gicas, as铆 como una adecuada apariencia superficial; por lo que la seleccionamos como mejor variante tecnol贸gica. De dicha formulaci贸n se derivaron granulados y tabletas con satisfactorias propiedades organol茅pticas, f铆sico-mec谩nicas y tecnol贸gicas. Los lotes de estabilidad fueron elaborados a escala piloto, demostrando la factibilidad del proceso de fabricaci贸n a esta escala. Las tabletas se envasaron en frascos pl谩sticos de polietileno de baja densidad. La estabilidad qu铆mica y microbiol贸gica del producto terminado fue estudiada durante 36 meses y los resultados demostraron la buena estabilidad del mismo.The development of nutritional supplements in solid form (tablets, capsules and granulated) starting from natural sources, is an area of constant interest in the pharmacist's investigation, with the purpose of achieving a stable system that has biological activity. With this projection it was designed a formulation of calcium and magnesium mitrate in form of chewables tablets. For this different technological assays were elaborated, being the formulation C the one that surrendered better physical-mechanical and technological properties, as well as an appropriate superficial appearance, and then was selected as the better technological variant. From this formulation were derived granulated and tablets with satisfactory organoleptic, physical-mechanical and technological properties. The stability lots were elaborated to pilot scale, demonstrating the feasibility from the process of production at this scale. The tablets were packed in plastic bottles of low-density polyethylene. The chemical and microbiological stability of the finished product was studied during 36 months, and the results demonstrated the good stability of it.Colegio de Farmac茅uticos de la Provincia de Buenos Aire
