Comparison of Total Tumor Volume, Size and Number of Colorectal Liver Metastases in Prediction of Survival in Patients after Liver Resection

Liver is the most common location of the colorectal cancer metastases occurrence. Liver resection is the only curative method of treatment. Unfortunately it is feasible only in 25% of patients with colorectal liver metastases, often because of the extensiveness of the disease. The aim of the study was to evaluate the predictive value of total tumor volume, size and number of colorectal liver metastases in patients treated with right hemihepatectomy. Material and methods. A retrospective analysis was performed in a group of 135 patients with colorectal liver metastases, who were treated with right hemihepatectomy. Total tumor volume was estimated based on the formula (4/3)πr3. Moreover, the study included an analysis of data on the number and size of tumors, radicality of the resection, time between primary tumor resection and liver resection, pre-operative blood serum concentration of carcinoembryonal antigen (CEA) and carcinoma antigen Ca19-9. The predictive value of the factors was evaluated by applying a Cox proportional hazards model and the area under the ROC curve. Results. The univariate analysis has shown the predictive value of size of the largest tumor (p=0.033; HR=1.065 per each cm) on the overall survival, however no predictive value of number of tumors (p=0.997; HR=1.000) and total tumor volume (p=0.212; HR=1.002) was observed. The multivariate analysis did not confirm the predictive value of the size of the largest tumor (p=0.141; HR=1.056). In the analysis of ROC curves, AUROC for the total tumor volume, the size of the largest tumor and the number of tumors were 0.629, 0.608, 0.520, respectively. Conclusions. Total tumor volume, size and number of liver metastases are not independent risk factors for the worse overall survival of patients with colorectal liver metastases treated with liver resection, therefore increased values of these factors should not be a contraindication for surgical treatmen

Selected papers : law : language, norms, reasoning

Księga zawiera selekcję artykułów Profesora Tomasza Gizbert-Studnickiego, zawierającą 26 prac uporządkowanych w pięciu częściach tematycznych: (I) Prawo i język; (II) Teoria norm; (III) Metodologia prawoznawstwa i filozofia prawa; (IV) Wykładnia prawa, rozumowania i argumentacja prawnicza; oraz (V) W stronę dogmatyki prawa. Spośród tych 26 prac, pięć zostało po raz pierwszy opublikowanych w polskim tłumaczeniu: Ilu teorii prawdy potrzebuje prawoznawstwo? (org. How Many Theories of Truth Are Needed in Jurisprudence?, w przekładzie Wojciecha Ciszewskiego), Hermeneutyczna świadomość prawników (org. Das hermeneutische Bewusstsein der Juristen, w przekładzie Pawła Banasia), O ciężarze argumentacji w sporach prawnych (org. The Burden of Argumentation in Legal Disputes, w przekładzie Adama Dyrdy), Nielingwistyczne pojęcie normy i ontologia (org. The Non-Linguistic Concept of Norm and Ontology, w przekładzie Andrzeja Grabowskiego) oraz Typy nieostrości (org. Types of Vagueness, w przekładzie Michała Araszkiewicza