Prognostic markers of the epithelial tumors of the large intestine

The surgical treatment of large bowel malignant tumors is now the most important therapeutic approach. The aim of our study was to evaluate a possible prognostic implication of ploidy and NM23 expression. The study includes 120 non selected patients who underwent surgery for colorectal cancer. The analysis of ploidy was obtained with cytometric test. The cases with only one gaff G0/G1 were considered as diploid. Patteras with more than one aneuploidic population were classified as multiploidic or poliploidic. While NM23 expression was evaluated with a double blind retrospective study by two separate equipe of authors in different centres. NM23 positivity degree was classified in 3 classes: absent or weak if 50%. Forty-two patients (35%) were classified as diploidic; 30 patients (25%) as aneuploidic; 40 patients (33.2%) as multiploidic; in 8 cases (6.7%) the material was inadequate. Among the two groups who evaluated NM23 expression the group I a positivity: absent or weak in 32 cases (26.7%); moderate in 62 cases (51.7%); strong in 26 cases (21.6%); while the group II shows positivity: absent or weak in 30 cases (25%); moderate in 52 cases (43.3%); strong in 38 cases (31.7%). We cannot consider ploidy and the NM23 research as independent prognostic factor

"Delirium Day": A nationwide point prevalence study of delirium in older hospitalized patients using an easy standardized diagnostic tool

Background: To date, delirium prevalence in adult acute hospital populations has been estimated generally from pooled findings of single-center studies and/or among specific patient populations. Furthermore, the number of participants in these studies has not exceeded a few hundred. To overcome these limitations, we have determined, in a multicenter study, the prevalence of delirium over a single day among a large population of patients admitted to acute and rehabilitation hospital wards in Italy. Methods: This is a point prevalence study (called "Delirium Day") including 1867 older patients (aged 65 years or more) across 108 acute and 12 rehabilitation wards in Italian hospitals. Delirium was assessed on the same day in all patients using the 4AT, a validated and briefly administered tool which does not require training. We also collected data regarding motoric subtypes of delirium, functional and nutritional status, dementia, comorbidity, medications, feeding tubes, peripheral venous and urinary catheters, and physical restraints. Results: The mean sample age was 82.0 ± 7.5 years (58 % female). Overall, 429 patients (22.9 %) had delirium. Hypoactive was the commonest subtype (132/344 patients, 38.5 %), followed by mixed, hyperactive, and nonmotoric delirium. The prevalence was highest in Neurology (28.5 %) and Geriatrics (24.7 %), lowest in Rehabilitation (14.0 %), and intermediate in Orthopedic (20.6 %) and Internal Medicine wards (21.4 %). In a multivariable logistic regression, age (odds ratio [OR] 1.03, 95 % confidence interval [CI] 1.01-1.05), Activities of Daily Living dependence (OR 1.19, 95 % CI 1.12-1.27), dementia (OR 3.25, 95 % CI 2.41-4.38), malnutrition (OR 2.01, 95 % CI 1.29-3.14), and use of antipsychotics (OR 2.03, 95 % CI 1.45-2.82), feeding tubes (OR 2.51, 95 % CI 1.11-5.66), peripheral venous catheters (OR 1.41, 95 % CI 1.06-1.87), urinary catheters (OR 1.73, 95 % CI 1.30-2.29), and physical restraints (OR 1.84, 95 % CI 1.40-2.40) were associated with delirium. Admission to Neurology wards was also associated with delirium (OR 2.00, 95 % CI 1.29-3.14), while admission to other settings was not. Conclusions: Delirium occurred in more than one out of five patients in acute and rehabilitation hospital wards. Prevalence was highest in Neurology and lowest in Rehabilitation divisions. The "Delirium Day" project might become a useful method to assess delirium across hospital settings and a benchmarking platform for future surveys

Prevalence of interstitial pneumonia suggestive of COVID-19 at 18F-FDG PET/CT in oncological asymptomatic patients in a high prevalence country during pandemic period: a national multi-centric retrospective study

67sinonenoneAlbano, Domenico; Bertagna, Francesco; Alongi, Pierpaolo; Baldari, Sergio; Baldoncini, Alfonso; Bartolomei, Mirco; Boccaletto, Franco; Boero, Michele; Borsatti, Eugenio; Bruno, Andrea; Burroni, Luca; Capoccetti, Francesca; Castellani, Massimo; Cervino, Anna Rita; Chierichetti, Franca; Ciarmiello, Andrea; Corso, Angelo; Cuocolo, Alberto; De Rimini, Maria Luisa; Deandreis, Desiree’; Dottorini, Massimo Eugenio; Esposito, Filomena; Farsad, Mohsen; Gasparini, Massimo; Grana, Chiara Maria; Gregianin, Michele; Guerra, Luca; Loreti, Fabio; Lupi, Andrea; Martino, Gianluigi; Milan, Elisa; Modoni, Sergio; Morbelli, Silvia; Muni, Alfredo; Nicolai, Emanuele; Palumbo, Barbara; Papa, Sergio; Papaleo, Alberto; Pellerito, Riccardo; Poti, Carlo; Romano, Pasquale; Rossetti, Claudio; Rossini, Pierluigi; Rubini, Giuseppe; Ruffini, Livia; Sacchetti, Gianmauro; Savelli, Giordano; Schiavariello, Saverio; Sciagrà, Roberto; Sciuto, Rosa; Seregni, Ettore; Sestini, Stelvio; Sicolo, Michele; Spanu, Angela; Storto, Giovanni; Balducci, Massimo Tosti; Trifirò, Giuseppe; Versari, Annibale; Vignati, Alberto; Volterrani, Duccio; Calcagni, Maria Lucia; Marzola, Maria Cristina; Garufo, Antonio; Evangelista, Laura; Maroldi, Roberto; Schillaci, Orazio; Giubbini, RaffaeleAlbano, Domenico; Bertagna, Francesco; Alongi, Pierpaolo; Baldari, Sergio; Baldoncini, Alfonso; Bartolomei, Mirco; Boccaletto, Franco; Boero, Michele; Borsatti, Eugenio; Bruno, Andrea; Burroni, Luca; Capoccetti, Francesca; Castellani, Massimo; Cervino, Anna Rita; Chierichetti, Franca; Ciarmiello, Andrea; Corso, Angelo; Cuocolo, Alberto; De Rimini, Maria Luisa; Deandreis, Desiree’; Dottorini, Massimo Eugenio; Esposito, Filomena; Farsad, Mohsen; Gasparini, Massimo; Grana, Chiara Maria; Gregianin, Michele; Guerra, Luca; Loreti, Fabio; Lupi, Andrea; Martino, Gianluigi; Milan, Elisa; Modoni, Sergio; Morbelli, Silvia; Muni, Alfredo; Nicolai, Emanuele; Palumbo, Barbara; Papa, Sergio; Papaleo, Alberto; Pellerito, Riccardo; Poti, Carlo; Romano, Pasquale; Rossetti, Claudio; Rossini, Pierluigi; Rubini, Giuseppe; Ruffini, Livia; Sacchetti, Gianmauro; Savelli, Giordano; Schiavariello, Saverio; Sciagrà, Roberto; Sciuto, Rosa; Seregni, Ettore; Sestini, Stelvio; Sicolo, Michele; Spanu, Angela; Storto, Giovanni; Balducci, Massimo Tosti; Trifirò, Giuseppe; Versari, Annibale; Vignati, Alberto; Volterrani, Duccio; Calcagni, Maria Lucia; Marzola, Maria Cristina; Garufo, Antonio; Evangelista, Laura; Maroldi, Roberto; Schillaci, Orazio; Giubbini, Raffael

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