Odds ratios per SD of measures of body fat distribution on having at least one cardiometabolic risk factor.

<p>Odds ratios per SD of measures of body fat distribution on having at least one cardiometabolic risk factor.</p

Association of measures of body fat distribution on having at least one cardiometabolic risk factor.

<p>Data are presented as odds ratio (95% CI) per standard deviation of measure of body fat distribution in men and women. WHR, waist:hip ratio; WC, waist circumference; aSAT, abdominal subcutaneous adipose tissue; VAT, visceral adipose tissue adjusted for age, ethnicity, education, tobacco smoking, alcohol consumption and physical activity. Associations of WHR, WC and VAT are additionally adjusted for total body fat and associations of aSAT additionally for VAT.</p

Significantly associated SNPs of the 6 top genes.

<p>SNP, single nucleotide polymorphism; Chr, chromosome; bp, base pair; MAF, minor allele frequency in control group; OR, odds ratio. The imputation quality indicates the average posterior probability for the most likely genotype generated by MACH, ranging from 0–1.</p

Q-Q plot for the GWAS after imputation on clinical restenosis in the GENDER study population. Lambda = 1.027.

<p>Q-Q plot for the GWAS after imputation on clinical restenosis in the GENDER study population. Lambda  = 1.027.</p

Baseline characteristics of study participants grouped by thyroid status.

<p>Abbreviations: n, number; se, standard error; IADL, Instrumental Activities of Daily Living; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; TIA, transient ischemic attack; HDL, high density cholesterol lipoprotein; LDL, low density cholesterol lipoprotein.</p>*<p> =  adjusted for sex and age at baseline, assessed by linear regression.</p

Association of thyroid status with cognitive performance during follow-up.

<p>Abbreviations: Est, estimates; se, standard error; MMSE, Mini-Mental State Examination; LDCT, Letter-Digit Coding Test; PLTi, Picture-Word Learning Test immediate; PLTd, Picture-Word Learning Test delayed. Estimates represent the additional change in various cognitive performance tests per year in different subclinical thyroid status. Adjusted for sex, age, education, country, treatment, apo E genotype and test version where appropriate.</p

Pathway Analysis Using Genome-Wide Association Study Data for Coronary Restenosis – A Potential Role for the PARVB Gene

<div><p>Background</p><p>Coronary restenosis after percutaneous coronary intervention (PCI) still remains a significant limitation of the procedure. The causative mechanisms of restenosis have not yet been fully identified. The goal of the current study was to perform gene-set analysis of biological pathways related to inflammation, proliferation, vascular function and transcriptional regulation on coronary restenosis to identify novel genes and pathways related to this condition.</p><p>Methods</p><p>The GENetic DEterminants of Restenosis (GENDER) databank contains genotypic data of 556,099SNPs of 295 cases with restenosis and 571 matched controls. Fifty-four pathways, related to known restenosis-related processes, were selected. Gene-set analysis was performed using PLINK, GRASS and ALIGATOR software. Pathways with a p<0.01 were fine-mapped and significantly associated SNPs were analyzed in an independent replication cohort.</p><p>Results</p><p>Six pathways (cell-extracellular matrix (ECM) interactions pathway, IL2 signaling pathway, IL6 signaling pathway, platelet derived growth factor pathway, vitamin D receptor pathway and the mitochondria pathway) were significantly associated in one or two of the software packages. Two SNPs in the cell-ECM interactions pathway were replicated in an independent restenosis cohort. No replication was obtained for the other pathways.</p><p>Conclusion</p><p>With these results we demonstrate a potential role of the cell-ECM interactions pathway in the development of coronary restenosis. These findings contribute to the increasing knowledge of the genetic etiology of restenosis formation and could serve as a hypothesis-generating effort for further functional studies.</p></div

Association of subclinical thyroid status and various cognitive performance tests at baseline.

<p>Abbreviations: MMSE, Mini-Mental State Examination; LDCT, Letter-Digit Coding Test; PLTi, Picture-Word Learning Test immediate; PLTd, Picture-Word Learning Test delayed. Cognitive tests were presented in mean (standard error). Associations were assessed by linear regression analyses, adjusted for sex, age, education, country, apo E genotype and test version where appropriate.</p

Pathways associated with restenosis with PLINK or GRASS.

<p>A complete overview of all pathways can be found in Supplementary <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0070676#pone.0070676.s001" target="_blank">Table S1</a>. NS, not significant (pathway did not meet test criteria).</p

Flowchart of study participants.

<p>Abbreviations: TSH, Thyroid Stimulating Hormone; FT4, free thyroxine.</p