Chromosomal localization of CTSL: expanding of the region of evolutionary conservation between GGAZ and HSA9

Source/description: Cathepsin L (CTSL) is a lysosomal cysteine proteinase with a major role in intracellular protein catabolism. It also shows the most potent collagenolytic and elastinolytic activity in vitro of any of the cathepsins. We report here for the first time the cytogenetic assignment of the chicken CTSL gene..

Chromosomal localization of the UBAP2Z and UBAP2W genes in chicken

Source/description: Ubiquitin-associated protein 2 (UBAP2) is a novel gene first isolated based on its expression in the human adrenal gland. The full-length protein encoded by this gene contains a ubiquitin-associated domain, a motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. In birds, UBAP2 is represented in two copies located on the Z and W chromosomes. In the recent chicken genome sequence assembly, the GGAZ and especially the GGAW sequences were poorly represented and assembled, so additional evidence for the location of Z- and W-linked loci should help to address this situation. Here, we report the cytogenetic assignment of large-insert clones for the chicken UBAP2 genes..