Discomfort relief after paracetamol administration in febrile children admitted to a third level paediatric emergency department

Backgroundinternational guidelines recommend treating fever in children not at a predefined body temperature limit but based on the presence of discomfort. However few studies evaluated discomfort relief after administration of antipyretics in children.MethodsBetween 1st January and 30th September 2021 a single-center prospective observational study was performed in febrile children consecutively admitted to a pediatric emergency department and treated with paracetamol orally. For each child, body temperature, presence and severity of discomfort, defined using a previously published semiquantitative likert scale, were evaluated at baseline and 60 min after administration of paracetamol, and differences were analyzed.Results172 children (males: 91/172; 52.9%; median age: 41.7 months) were included. Significant reductions in body temperature (median body temperature at T0: 38.9 °C; IQR: 38.3–39.4, median body temperature at T60: 36.9 °C; IQR: 36.4–37.5; P Conclusionsparacetamol in febrile children is associated not only with significantly reduction in body temperature but also with discomfort relief.</p

Additional file 1: of Patterns of adiposity, vascular phenotypes and cognitive function in the 1946 British Birth Cohort

Additional Methods and Results (including additional Tables and Figures). (DOC 688 kb

Additional file 2: of Characterization of serious adverse drug reactions as cause of emergency department visit in children: a 5-years active pharmacovigilance study

Table S2. Most frequent suspect vaccines, overall and stratified according to seriousness. This table reported the most frequent suspected vaccines. (DOCX 14 kb

Additional file 1: of Characterization of serious adverse drug reactions as cause of emergency department visit in children: a 5-years active pharmacovigilance study

Table S1. Most frequent suspect APs among antinfective for systemic use agents (ATC class J) and nervous system medications (ATC class N), overall and stratified according to ADR seriousness. This table reported the most frequent suspected active principles (APs) among antinfectives for systemic use agents and nervous system medications. (DOCX 48 kb