536 research outputs found

    Anemia in the elderly: clinical implications and new therapeutic concepts

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    A propos du « Dendroctonus micans »

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    Konzeption und Entwicklung eines Condition Monitoring Systems mit Low Cost Sensoren zur Ăśberwachung von Roboterschwingungen

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    Im Rahmen dieser Veröffentlichung wird ein Konzept zur Erfassung des Schwingungsverhaltens von Industrierobotern mit Hilfe von Low Cost Sensoren vorgestellt. Durch dieses sollen die dynamischen Eigenschaften des Industrieroboters im gesamten Arbeitsraum untersucht werden. Die Roboterstruktur wird dazu durch eine speziell konstruierte Unwuchtscheibe angeregt. Das Messsystem besteht aus einem Beschleunigungssensor, einem Arduino-Mikrocontroller und einem eigens entwickelten Mess- und Auswerteprogramm in der Softwareumgebung MATLAB®. Die Validierung des Konzeptes erfolgt jeweils mit Messreihen an einem Kragbalken sowie an einem Industrieroboter durch den Vergleich mit einem Referenzmesssystem der Firma Brüel & Kjaer. Durch das entwickelte Low Cost Condition Monitoring System lassen sich die Anregungsfrequenzen und –amplituden mit hinreichender Genauigkeit erfassen und Rückschlüsse auf das Schwingungsverhalten des Industrieroboters ziehen

    Manipulation of Fgf and Bmp signaling in teleost fishes suggests potential pathways for the evolutionary origin of multicuspid teeth

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    Teeth with two or more cusps have arisen independently from an ancestral unicuspid condition in a variety of vertebrate lineages, including sharks, teleost fishes, amphibians, lizards, and mammals. One potential explanation for the repeated origins of multicuspid teeth is the existence of multiple adaptive pathways leading to them, as suggested by their different uses in these lineages. Another is that the addition of cusps required only minor changes in genetic pathways regulating tooth development. Here we provide support for the latter hypothesis by demonstrating that manipulation of the levels of Fibroblast growth factor (Fgf) or Bone morphogenetic protein (Bmp) signaling produces bicuspid teeth in the zebrafish (Danio rerio), a species lacking multicuspid teeth in its ancestry. The generality of these results for teleosts is suggested by the conversion of unicuspid pharyngeal teeth into bicuspid teeth by similar manipulations of the Mexican Tetra (Astyanax mexicanus). That these manipulations also produced supernumerary teeth in both species supports previous suggestions of similarities in the molecular control of tooth and cusp number. We conclude that despite their apparent complexity, the evolutionary origin of multicuspid teeth is positively constrained, likely requiring only slight modifications of a pre-existing mechanism for patterning the number and spacing of individual teeth. © 2013 Wiley Periodicals, Inc

    Distributed Ledger for Provenance Tracking of Artificial Intelligence Assets

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    High availability of data is responsible for the current trends in Artificial Intelligence (AI) and Machine Learning (ML). However, high-grade datasets are reluctantly shared between actors because of lacking trust and fear of losing control. Provenance tracing systems are a possible measure to build trust by improving transparency. Especially the tracing of AI assets along complete AI value chains bears various challenges such as trust, privacy, confidentiality, traceability, and fair remuneration. In this paper we design a graph-based provenance model for AI assets and their relations within an AI value chain. Moreover, we propose a protocol to exchange AI assets securely to selected parties. The provenance model and exchange protocol are then combined and implemented as a smart contract on a permission-less blockchain. We show how the smart contract enables the tracing of AI assets in an existing industry use case while solving all challenges. Consequently, our smart contract helps to increase traceability and transparency, encourages trust between actors and thus fosters collaboration between them

    Aging and blood disorders: new perspectives, new challenges

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    Off-Axis Response Measurement of the Sounding of the Atmosphere Using Broadband Emission Radiometry (SABER) Telescope

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    The Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) instrument is a 10-channel earth limb-viewing sensor that measures atmospheric emissions in the spectral range of 1.27 μm to 16.9 μm. SABER is part of NASA’s Thermosphere-Ionosphere-Mesosphere Energetics and Dynamics (TIMED) mission, which was successfully launched in December 2001. Uncommon among limb-viewing sensors, SABER employs an on-axis telescope design with reimaging optics to allow for an intermediate field stop and a Lyot stop. Additional stray light protection is achieved by an innovative inner Lyot stop, which is placed conjugate to the secondary obscuration and support structure. Presented in this paper is the off-axis response of SABER as measured in the Terrestrial Black Hole off-axis scatter facility at the Space Dynamics Laboratory. The measurement was made at visible wavelengths; thus, the response is only representative of SABER’s short wavelength channels. The measurement validated the stray light design and complemented the APART software model, which predicts that mirror scatter is the dominant stray light mechanism at short wavelengths. In addition, estimates of the mirror bi-directional reflectance distribution function (BRDF) were made. The off-axis response measurement indicates that SABER is an exceptional stray light suppression telescope

    Expression and modulation of CD44 variant isoforms in humans

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