John Dewey e William James sulla fenomenologia del comportamento

Questo saggio si propone di esaminare, conformemente alla prospettiva pragmatista, la struttura fisiologica delle abitudini e dell\u2019articolato concetto di comportamento umano, delineato nella sua funzionale interconnessione con il corpo sociale. Nel 1896 John Dewey pubblica il lavoro Il concetto di arco riflesso in psicologia in cui tratta un tema cardine della fisiologia e della psicologia classica. Quello dell\u2019unit\ue0 delle attivit\ue0 mentali che determinano l\u2019acquisizione di un comportamento. L\u2019analisi deweyana, nel confronto con il concetto di esperienza elaborato da William James, intende superare la nozione empirica di arco riflesso, mostrando la coordinazione di sensazione, pensiero e azione, e arrivando a definire la configurazione dinamica dell\u2019atto cognitivo di un circuito organico

Lovelace Foundation Reports

Report regarding a device used to monitor dogs that are being exposed to radioactive aerosols for experimental purposes

Pigmentary retinopathy can indicate the presence of pathogenic LAMP2 variants even in somatic mosaic carriers with no additional signs of Danon disease

PURPOSE: Danon disease (DD) is a rare X-linked disorder caused by pathogenic variants in LAMP2. DD primarily manifests as a severe cardiomyopathy. An early diagnosis is crucial for patient survival. The aim of the study was to determine the usefulness of ocular examination for identification of DD. METHODS: Detailed ocular examination in 10 patients with DD (3 males, 7 females) and a 45-year-old asymptomatic female somatic mosaic carrier of a LAMP2 disease-causing variant. RESULTS: All patients with manifest cardiomyopathy had pigmentary retinopathy with altered autofluorescence and diffuse visual field loss. Best corrected visual acuity (BCVA) was decreased (<0.63) in 8 (40%) out of 20 eyes. The severity of retinal pathology increased with age, resulting in marked cone-rod involvement overtime. Spectral-domain optical coherence tomography in younger patients revealed focal loss of photoreceptors, disruption and deposition at the retinal pigment epithelium/Bruch's membrane layer (corresponding to areas of marked increased autofluorescence), and hyperreflective foci in the outer nuclear layer. Cystoid macular oedema was seen in one eye. In the asymptomatic female with somatic mosaicism, the BCVA was 1.0 bilaterally. An abnormal autofluorescence pattern in the left eye was present; while full-field electroretinography was normal. CONCLUSIONS: Detailed ocular examination may represent a sensitive and quick screening tool for the identification of carriers of LAMP2 pathogenic variants, even in somatic mosaicism. Hence, further investigation should be undertaken in all patients with pigmentary retinal dystrophy as it may be a sign of a life-threatening disease