Manuale per la gestione integrata degli stabulari. Principi e indicazioni per la protezione degli animali e la sicurezza dei lavoratori

Il volume è l’edizione aggiornata del “Manuale per la gestione integrata degli stabulari” - principi e indicazioni per la protezione degli animali e la sicurezza dei lavoratori – (2012), divenuta necessaria in seguito alla emanazione della Direttiva 2010/63/UE, revisione della Direttiva 86/609, recepita in Italia con il Decreto Legislativo 26/2014 il 4 marzo 2014. Il Manuale è redatto secondo un approccio integrato che considera contestualmente sia gli aspetti riguardanti la sperimentazione animale sia quelli di sicurezza e salute degli operatori e dei ricercatori

Healthy Diet to Prevent Cardiovascular Diseases and Osteoporosis

The ProSa (PROmozione e tutela della SAlute) Project ('Health Promotion Project') is a workplace programme geared to promote health among the Roman staff of the National Research Council of Italy. 789 employees of both genders (450 men, 339 women) have participated in the cardiovascular prevention programme (screening, computerized calculation of the risk level, dietary and pharmacological intervention) and 245 women have participated in the osteoporosis programme (calcaneal ultrasonometer test, dietary and pharmacological intervention). Menopause increases the risk of cardiovascular diseases and osteoporosis. In order to lower dietary fat content, dietary intake of calcium and vitamin D could be reduced. However, supplementation of both may not be necessary if we follow an integrated dietary approach. Therefore, for women in menopause with mixed hyperlipidaemia (hypercholesterolaemia and/or hypertriglyceridaemia) and/or overweight/obesity, dietary intervention was aimed at promoting the choice of foods low in fats and rich in calcium based on a list of recommended products distributed to all the participants. The dietary intervention was accompanied by a programme of regular physical activity with adequate exposure to sunlight. By following a balanced diet it is possible to improve the prognosis not only for hyperlipidaemic patients, but also for patients with signs of osteopaenia or osteoporosis

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

peer reviewedThe genetic basis of Lewy body dementia (LBD) is not well understood. Here, we performed whole-genome sequencing in large cohorts of LBD cases and neurologically healthy controls to study the genetic architecture of this understudied form of dementia, and to generate a resource for the scientific community. Genome-wide association analysis identified five independent risk loci, whereas genome-wide gene-aggregation tests implicated mutations in the gene GBA. Genetic risk scores demonstrate that LBD shares risk profiles and pathways with Alzheimer’s disease and Parkinson’s disease, providing a deeper molecular understanding of the complex genetic architecture of this age-related neurodegenerative condition