The Effect of Premedication by Remifentanil and Magnesium Sulfate in Hemodynamic Responses to Tracheal Intubation in Cesarean Section Delivery: 1 A Randomized Double-Blinded Controlled Study

Background: The preventing effects of remifentanil and magnesium sulfate on hemodynamic responses to tracheal intubation were evaluated in a double-blinded controlled trial on pregnant women undergoing cesarean section delivery.Methods: A total of 54 American Society of Anesthesiologists Class I-II women candidate for cesarean section delivery were randomly assigned to one of three groups (n = 18) to receive one of the following premedication: Intravenous (IV) remifentanil 0.75 µg/kg, IV magnesium sulfate 30 mg/kg, or IV normal saline 10 cc as placebo. All hemodynamic profiles were recorded immediately before and after intubation, and 2, 3, 5 minutes after tracheal intubation.Results: Heart rate and systolic and diastolic blood pressures were significantly lower in the remifentanil group than in other groups both before and immediately after intubation. The trend of the changes in homodynamic responses within 5 minutes following intubation in the magnesium sulfate and placebo group was similar, but this trend in the remifentanil group was significant difference. In the same time, 1st and 5th minute Apgar scores were slightly lower in the remifentanil group than others. The measured parameters of umbilical cord blood pH and PO had no significant differences between the groups.Conclusions: Remifentanil can attenuate hemodynamic response to tracheal intubation more effectively than magnesium sulfate, and thus it can be considered safe for a pregnant candidate for cesarean section

Pedobarography of the coper and non-coper ACL-deficient knee subjects during single and double leg stance

Introduction: Biomechanical studies have frequently shown a close relationship between the knee and ankle joint movements. ACL-deficiency may change the foot pressure pattern of the ACL-deficient knee subjects. The current study aimed to investigate the pattern of the foot pressure in coper and non-coper ACL-deficient knee subjects during standing on one and both feet. Methods and Materials: This case-control study was conducted on 12 coper and 12 non-coper ACL-deficient knee subjects and 25 age-sex matched healthy subjects. The subjects were tested barefoot during single and bilateral standing on the platform of a Zebris pedobarograph tool. The outcome measures included the measurements of the pressures of each part of the foot during the tests. Results: The results showed a significantly decreased total pressure only between the non-coper and control groups during double leg stance test. In terms of the forefoot pressure, a significant increased pressure was shown only in the non-coper ACL-deficient knee subjects during both single and double leg stance tests (P<0.05). In both test conditions, the coper ACL-deficient knee subjects showed forefoot and hind foot pressures very close to the control group (P>0.05). Conclusion: This study revealed marked changes following ACL-deficiency mainlyin non-coper ACL-deficient knee subjects. The increased forefoot pressure in non-coper ACL-deficient knee subjects was probably due to the forwarded line of gravity in these patients aligned with their base of support to keep their knees more stable. Further studies are needed to verify the differences between the male and female ACL-deficient knee subjects.Keywords: Coper/non-coper ACL-deficient knee subjects; Stability; Pedobarograph; Foot pressure system; Postural contro

Association between tumor markers and anemia: a short review

Tumor markers are a group of molecules used to diagnose certain diseases, including cancer. These molecules can alter cellular pathways, including those associated with some anemias, by expressing or influencing certain cellular mediators. The present study is based on data obtained from the PubMed database (1970–2019) using the key words ‘tumor markers’, ’anemia’ and ‘iron’. We found that some tumor markers can affect hepcidin expression and iron uptake by altering cell pathways. Several other tumor markers also increase in some anemias, so that they can sometimes be used to diagnose and confirm the type of anemia. The role of some tumor markers remains unclear despite the increase in some anemias. In general, some tumor markers are involved in the pathophysiology of a numer of anemias or help diagnose anemia. However, studies of the role of tumor markers in the diagnosis, development or progression of anemias have been very limited

Association Between Metabolic Syndrome and Stroke: A Population Based Cohort Study

Both metabolic syndrome (MetS) and stroke are associated with increased risk of mortality. Here, we aimed to assess the prevalence of MetS among adults using three definitions (Adult Treatment Panel III (ATP-III), International Diabetes Federation (IDF) and IDF ethnic specific cut-off for Iranian criteria) and its association with stroke. We performed a cross-sectional study of a total of 9991 adult participants of Rafsanjan Cohort Study (RCS), as part of the Prospective epidemiological research studies in Iran (PERSIAN cohort study). The MetS prevalence was evaluated in participants according to the different criteria. Multivariate logistic regression analyses were conducted to assess the association between three definitions of MetS with stroke. We found that MetS was significantly associated with higher odds of stroke according to NCEP-ATP III (odds ratio (OR): 1.89, 95% confidence interval (CI) 1.30-2.74), international IDF (OR:1.66, 95% CI: 1.15-2.40) and Iranian IDF (OR:1.48, 95% CI: 1.04-2.09) after adjusted for variables confounders. Furthermore, after adjustment, in receiver operating characteristic (ROC) curve, the AUROC was 0.79 (95% CI = 0.75-0.82), 0.78(95% CI = 0.74-0.82) and 0.78(95% CI = 0.74-0.81) for presence of MetS according to NCEP-ATP III, international IDF and Iranian IDF, respectively. ROC analyses revealed that all of these three criteria for MetS are moderately accurate for the identification of increased stroke risk.In conclusion, our results showed that MetS was associated with increased odds of stroke. Our findings implicate the importance of early identification, treatment, and ultimately prevention of the metabolic syndrome

A Dynamic Popularity-Aware Load Balancing Algorithm for Structured P2P Systems

Part 2: Network Architecture and Protocol DesignInternational audienceLoad balancing is one of the main challenges of structured P2P systems that use distributed hash tables (DHT) to map data items (objects) onto the nodes of the system. In a typical P2P system with N nodes, the use of random hash functions for distributing keys among peer nodes can lead to O(log N) imbalance. Most existing load balancing algorithms for structured P2Psystems are not proximity-aware, assume uniform distribution of objects in the system and often ignore node heterogeneity. In this paper we propose a load balancing algorithm that considers node heterogeneity, changes in object popularities, and link latencies between nodes. It also considers the load transfer time as an important factor in calculating the cost of load balancing. We present the algorithm using node movement and replication mechanisms. We also show via simulation how well the algorithm performs under different loads in a typical structured P2P system

Smoking, alcohol and opioids effect on coronary microcirculation: an update overview.

Smoking, heavy alcohol drinking and drug abuse are detrimental lifestyle factors leading to loss of million years of healthy life annually. One of the major health complications caused by these substances is the development of cardiovascular diseases (CVD), which accounts for a significant proportion of substance-induced death. Smoking and excessive alcohol consumption are related to the higher risk of acute myocardial infarction. Similarly, opioid addiction, as one of the most commonly used substances worldwide, is associated with cardiac events such as ischemia and myocardial infarction (MI). As supported by many studies, coronary artery disease (CAD) is considered as a major cause for substance-induced cardiac events. Nonetheless, over the last three decades, a growing body of evidence indicates that a significant proportion of substance-induced cardiac ischemia or MI cases, do not manifest any signs of CAD. In the absence of CAD, the coronary microvascular dysfunction is believed to be the main underlying reason for CVD. To date, comprehensive literature reviews have been published on the clinicopathology of CAD caused by smoking and opioids, as well as macrovascular pathological features of the alcoholic cardiomyopathy. However, to the best of our knowledge there is no review article about the impact of these substances on the coronary microvascular network. Therefore, the present review will focus on the current understanding of the pathophysiological alterations in the coronary microcirculation triggered by smoking, alcohol and opioids

Association between tumor markers and anemia: a short review

Tumor markers are a group of molecules used to diagnose certain diseases, including cancer. These molecules can alter cellular pathways, including those associated with some anemias, by expressing or influencing certain cellular mediators. The present study is based on data obtained from the PubMed database (1970–2019) using the key words ‘tumor markers’, ’anemia’ and ‘iron’. We found that some tumor markers can affect hepcidin expression and iron uptake by altering cell pathways. Several other tumor markers also increase in some anemias, so that they can sometimes be used to diagnose and confirm the type of anemia. The role of some tumor markers remains unclear despite the increase in some anemias. In general, some tumor markers are involved in the pathophysiology of a number of anemias or help diagnose anemia. However, studies of the role of tumor markers in the diagnosis, development or progression of anemias have been very limited

Effects of Dimethyl Sulfoxide on Neuronal Response Characteristics in Deep Layers of Rat Barrel Cortex

Introduction: Dimethyl sulfoxide (DMSO) is a chemical often used as a solvent for waterinsoluble drugs. In this study, we evaluated the effect of intracerebroventricular (ICV) administration of DMSO on neural response characteristics (in 1200–1500 μm depth) of the rat barrel cortex. Methods: DMSO solution was prepared in 10% v/v concentration and injected into the lateral ventricle of rats. Neuronal spontaneous activity and neuronal responses to deflection of the principal whisker (PW) and adjacent whisker (AW) were recorded in barrel cortex. A condition test ratio (CTR) was used to measure inhibitory receptive fields in barrel cortex. Results: The results showed that both PW and AW evoked ON and OFF responses, neuronal spontaneous activity and inhibitory receptive fields did not change following ICV administration of DMSO. Conclusion: Results of this study suggest that acute ICV administration of 10% DMSO did not modulate the electrophysiological characteristics of neurons in the l deep ayers of rat barrel cortex

Association between metabolic syndrome and stroke: a population based cohort study

Abstract Both metabolic syndrome (MetS) and stroke are associated with increased risk of mortality. Here, we aimed to assess the prevalence of MetS among adults using three definitions (Adult Treatment Panel III (ATP-III), International Diabetes Federation (IDF) and IDF ethnic specific cut-off for Iranian criteria) and its association with stroke. We performed a cross-sectional study of a total of 9991 adult participants of Rafsanjan Cohort Study (RCS), as part of the Prospective epidemiological research studies in Iran (PERSIAN cohort study). The MetS prevalence was evaluated in participants according to the different criteria. Multivariate logistic regression analyses were conducted to assess the association between three definitions of MetS with stroke. We found that MetS was significantly associated with higher odds of stroke according to NCEP-ATP III (odds ratio (OR): 1.89, 95% confidence interval (CI) 1.30–2.74), international IDF (OR:1.66, 95% CI: 1.15–2.40) and Iranian IDF (OR:1.48, 95% CI: 1.04–2.09) after adjusted for variables confounders. Furthermore, after adjustment, in receiver operating characteristic (ROC) curve, the AUROC was 0.79 (95% CI = 0.75–0.82), 0.78(95% CI = 0.74–0.82) and 0.78(95% CI = 0.74–0.81) for presence of MetS according to NCEP-ATP III, international IDF and Iranian IDF, respectively. ROC analyses revealed that all of these three criteria for MetS are “moderately accurate” for the identification of increased stroke risk. In conclusion, our results showed that MetS was associated with increased odds of stroke. Our findings implicate the importance of early identification, treatment, and ultimately prevention of the metabolic syndrome