Linking Trade and Transport Statistics: the Dutch Case

International trade flows are important for a trading nation such as the Netherlands. They are an important source of income, value added, and welfare. Trade flows are strongly related to transport flows of goods to and from a country. However, not all international transport flows through a country are registered as merchandize trade flows. For example, transit flows of goods are not recorded in international merchandize trade statistics. Such flows can just as well serve as a basis for value added, though. For example, goods transferred in Rotterdam harbour and transported and distributed by Dutch logistics firms create a basis for value added in services trade. Moreover, transport flows of goods entail costs as well, such as the costs of traffic congestion and environmental pollution. Therefore, it is of interest to have good information on the value and quantities of goods transported through countries, and the modes of transport used for various types of flows. For this purpose, we need integrated statistics on trade flows and transport flows in goods. To be able to match trade and transit flows with transport statistics, complete and plausible information on mode of transport and gross weight is needed. This paper describes the scope and coverage of trade statistics in comparison to transport statistics for the Netherlands. We use transport statistics to allocate the plausible mode of transport to trade and transit flows. Creating an integrated view on trade and transport flows in goods, the paper intends to contribute to an improved understanding of the impact of merchandize trade and transit flows on the economy, both in terms of domestic value added and in terms of potential social costs related to congestion and the emission of pollutants.

The role of multidrug resistance in normal and leukemic progenitor cells

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A low but functionally significant MDR1 expression protects primitive haemopoietic progenitor cells from anthracycline toxicity

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New developments in the treatment of acute myeloid leukemia.

Item does not contain fulltextRemission induction therapy fails in 20-30% of the patients with acute myeloid leukemia (AML) despite dose intensification and the use of new and more effective drugs. Primary and acquired drug resistance, metabolic or kinetic are a fundamental problem. Expression of the P-glycoprotein in AML is correlated with therapeutic outcome. Randomized clinical studies with Pgp modulators are currently on-going. Ara-C and anthracyclines, are preferentially cytotoxic to proliferating cells. Proliferation induction of leukemia blasts with growth factors in vitro resulted in an increased toxicity of Ara-C and anthracyclines. Normal hematopoietic blast cells with a high Pgp expression are noncycling and less sensitive to anthracyclines, in contrast to the more proliferating cells with a low Pgp expression. Proliferation induction by growth factors results in a down regulation of Pgp expression. Priming of leukemic cells with growth factors in vivo might be promising and randomized clinical studies are warranted

Triggering noncycling hematopoietic progenitors and leukemic blasts to proliferatie increases anthracycline retention and toxicity by downregulating multidrug resistance

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Long-term treatment of transfusional iron overload with the oral iron chelator deferiprone (L1): a Dutch multicenter trial

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Cyclosporin increases cellular idarubicin and idarubicinol concentrations in relapsed or refractory AML mainly due to reduced systemic clearance

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Idarubicin DNA intercalation is reduced by MRP1 and not Pgp

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