2 research outputs found
Kidney and Cardiovascular Effects of Canagliflozin According to Age and Sex: A Post Hoc Analysis of the CREDENCE Randomized Clinical Trial
- Author
- Abdallah Joseph
- Abdul Ghani Rohana
- Abdullah Raied
- Abejuela Zaynab
- Abouglila Kamal
- Abraham Oomman
- Abraira Munoz Luis David
- Abramowitz Matthew
- Abusnana Salah
- Acosta Idalia
- Agafyina Alina
- Agarwal Rajiv
- Agarwal Rajiv
- Aggarwal Naresh
- Agra Jeimeen
- Ahmad Nik Nur Fatnoon Nik
- Ahmed Fayzal
- Aiello Joseph
- Ainsworth Paul
- Aizenberg Diego
- Aizenberg Diego
- Akiyama Hitoshi
- Akright Laura
- Akyea-Djamson Ayim
- Al-Karadsheh Amer
- Alamartine Eric
- Alappan Rajendran
- Albisu Juan Pablo
- Alexandra Terront Lozano Monica
- Ali Norsiah
- Ali Zishan
- Alicic Radica
- Allison Dale Crawford
- Alvarisqueta Andres
- Amodeo Celso
- Andreeva Viktoria
- Angelescu Liliana Monica
- Angelova Angelina
- Anghel Veronica
- Antic Slobodan
- Aoki Hiromi
- Aquitania Grace
- Arauz-Pacheco Carlos
- Arcos Edgar
- Arfeen Shahabul
- Arif Ahmed
- Arnott Clare
- Aronson Ronnie
- Arutchelvam Vijayaraman
- Arvind Moogali
- Asano Akimichi
- Atray Naveen
- Avendano Jorge
- Avram Rodica-Ioana
- Awad Ahmed
- Babikova Jana
- Badat Aysha
- Bajaj Harpreet
- Baker John
- Bakris George
- Bakris George
- Bakris George
- Ballesteros Cecilia Garcia
- Barbarash Olga
- Barna Olga
- Barnard Maria
- Barnhill Peggy
- Baron Paul Frenk
- Barranco Elizabeth
- Barrera Carlos
- Barrios Clara
- Bartaskova Dagmar
- Bartolacci Ines
- Barton Petr
- Barysheva Olga
- Beacom Matthew
- Behara Venkata
- Bellary Srikanth
- Belo Diogo
- Belobradkova Jana
- Bentley-Lewis Rhonda
- Benusova Olga
- Berenguer Ramon
- Berli Mario Alberto
- Bermudez Lidia
- Bernardo Marializa
- Bhushan Raju Sree
- Bijata-Bronisz Renata
- Bilyk Svitlana D.
- Biscoveanu Mihaela
- Bonadonna Riccardo
- Bordonava Anselmo
- Borges João Lindolfo Cunha
- Borot Sophie
- Botsyurko Volodymyr
- Bowman-Stroud Cynthia
- Brandon Donald
- Breedt Johannes
- Bregman Rachel
- Brenner Barry M.
- Brusco Osvaldo
- Buganova Ingrid
- Burst Volker
- Busch Robert
- Busegeanu Mihaela-Magdalena
- Calcaneo Juan Peralta
- Calella Pedro
- Canaan Yamil
- Canani Luis Henrique
- Cannon Christopher P.
- Cannon Christopher P.
- Canonge Rafael Simo
- Cantero Maria Cecilia
- Cardoza Kathryn
- Caringal Clodoaido
- Cariou Bertrand
- Carrillo Luis Venegas
- Cartasegna Luis Rodolfo
- Casabella Tomas Smith
- Castellanos Ricardo Orozco
- Castellino Pietro
- Castro Fernando Cereto
- Cepeda Alejandro Valdes
- Cercos Esteban
- Ceriello Antonio
- Chacra Antônio Roberto
- Chae Dong-Wan
- Chae Dong-Wan
- Chandra Vyasam Ramesh
- Chang Chwen-Tzuei
- Chang Tara
- Charytan David M.
- Charytan David M.
- Charytan David M.
- Chavez Eloisa Tellez
- Che Yusof Mohd Daud
- Chen Nan
- Chen Qinkai
- Cherney David
- Cherney David
- Chertow Glenn
- Cheung Ngai Wah
- Chilito Alicia
- Chiovato Luca
- Chizhov Daniil
- Cho Young Min
- Chouinard Guy
- Christensen Tom
- Christiano Cynthia
- Christofides Elena
- Chuang Lee-Ming
- Chuateco Caroucel
- Cif Adriana
- Cohen Kenneth
- Cohen Robert
- Cohen-Stein Debbie
- Colaso Patricia del Carmen Gonzalez
- Coloma Gabriela Cecilia
- Colombo Hugo
- Cometa Luis Valderrama
- Comia Rhea Severina
- Commendatore Victor
- Contieri Fabiana Loss de Carvalho
- Conway James
- Cook Charles
- Correa Rotter Jose Ricardo
- Cosma Dana
- Costa Fernando Augusto Alves da
- Cournoyer Serge
- Coyne Daniel
- Crisan Carmen
- Cruz Juan Baas
- Csecsei Gyongyi
- Csiky Botond
- Cuadrado Jesus
- Culak Jan
- Cuneo Carlos Alberto
- Cusumano Ana Maria
- Daboul Nizar
- Danos Peter
- DaRoza Gerald
- Darwish Riad
- Daswani Adarsh
- David null
- Davies Emyr
- Davies Mark
- Davies Simon
- Dawson Alison
- de Almeida Roberto Simões
- de Brito Claudia Moreira
- De Cosmo Salvatore
- De Nicola Luca
- De Nicola Luca
- de Salazar Dora Inés Molina
- De Serres Sacha
- de Souza Pedro
- de Zeeuw Dick
- de Zeeuw Dick
- Deak Laszlo
- Deboni Luciane Mônica
- Deck Kenneth
- Deepak Dewan
- del Campo Blanco Belia Martin
- Demian Luiza Despina
- Derosa Giuseppe
- Desouza Cyrus
- Dev Devasmita
- Dhillon Monika
- Di Carlo Alberto
- Di Cianni Graziano
- Di Tanna Gian Luca
- Diaz Ruiz Jorge Ernesto Andres
- Dimitrov Stefan
- Distiller Larry
- Distiller Lawrence
- Djordjevic Miodrag
- Dobronravov Vladimir
- Dohnalova Lenka
- Douthat Walter Guillermo
- Dran Ricardo Dario
- Drasnar Tomas
- Dreval Alexander
- Dreval Alexander
- Droste Carolyn
- Dua Sohan
- Dubé François
- Dudar Iryna
- Dudas Mihaly
- Dussol Bertrand
- Dzupina Andrej
- Dzuponova Jana
- d’Avila Domingos
- Eder Frank
- Edwin Fernando M.
- Egido de los Rios Jesus
- El Kossi Mohsen
- El-Shahawy Mohamed
- Elosegui Ana Maria
- English Patrick
- Enriquez Sosa Favio Edmundo
- Ervin John
- Escalante Tonatiu Diaz
- Escobedo Rolando Zamarripa
- Esquenazi Alberto
- Evans John
- Faghih Markus
- Farias Eduardo
- Fariña Marcelo Medina
- Faulmann Grit
- Fauvel Jean-Pierre
- Felício João Soares
- Ferariu Ioana Emilia
- Ferkl Richard
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- Filho Roberto Pecoits
- Finkelstein Hernan
- Fishbane Steven
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- Gomes Marcus
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- Gomez Olivert
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- Gonzalez Orellana Ronaldo Arturo
- Gonzalez Alexander
- Gonzalez Alfonso Soto
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- Gopalakrishnan Natarajan
- Gorson David
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- Heerspink Hiddo J. L.
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- Veronelli Anna Maria
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- Villegas Ivan
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- Vlasenko Maryna
- Vorobyev Sergey
- Vukotic Goga
- Wada Takashi
- Wada Takashi
- Wadud Khurram
- Wahba Mona
- Wakasugi Masakiyo
- Wakeling John
- Wakida Yasushi
- Walker Robert
- Wang Guixia
- Warren Mark
- Wassermann Alfredo
- Watanabe Takayuki
- Watson Edward
- Watson Henry
- Watts Ronald
- Weiner Daniel
- Weiner Pavel
- Welker James
- Welsh Jean
- Wheeler C.
- Wheeler David
- Wheeler David C.
- Wheeler David C.
- Williams Michael
- Williams Shelley
- Winocour Peter
- Wong Alfredo Chew
- Woo Vincent
- Yakov Andrian
- Yamada Masayo
- Yamada Sérgio
- Yanagida Kazuhiro
- Yanase Toshihiko
- Yang Jinkui
- Yao Christy
- Yap Yvette Ethel
- Yi Tae Won
- Yin Aiping
- Yoon Kun Ho
- Young Simon
- Yu Xueqing
- Yumita Wataru
- Yupanqui Hernan
- Zaidman Cesar Javier
- Zalunardo Nadia
- Zanella Maria Teresa
- Zaniewski-Singh Michelle
- Zanoli Luca
- Zaoui Philippe
- Zateyshchikova Anna
- Zateyshshikov Dmitry
- Zemek Stanislav
- Zhang Hong
- Zhang Hong
- Zhang Hong
- Zhao Minghui
- Zheng Hongguang
- Zinman Bernard
- Zinman Bernard
- Zlova Tetiana
- Zsom Marianna
- Zub Liliia
- Zykova Tatyana
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Rationale & Objective: It is unclear whether the effect of canagliflozin on adverse kidney and cardiovascular events in those with diabetic kid-ney disease varies by age and sex. We assessed the effects of canagliflozin among age group categories and between sexes in the Canagli-flozin and Renal Endpoints in Diabetes with Established Nephropathy Clinical Evaluation (CREDENCE) study.Study Design: Secondary analysis of a random-ized controlled trial. Setting & Participants: Participants in the CREDENCE trial. Intervention: Participants were randomly assigned to receive canagliflozin 100 mg/d or placebo.Outcomes: Primary composite outcome of kid-ney failure, doubling of serum creatinine con-centration, or death due to kidney or cardiovascular disease. Prespecified secondary and safety outcomes were also analyzed. Out-comes were evaluated by age at baseline (<60, 60-69, and >_70 years) and sex in the intention-to-treat population using Cox regression models.Results: The mean age of the cohort was 63.0 & PLUSMN; 9.2 years, and 34% were female. Older age and female sex were independently associ-ated with a lower risk of the composite of adverse kidney outcomes. There was no evidence that the effect of canagliflozin on the primary outcome (acomposite of kidney failure, a doubling of serum creatinine concentration, or death from kidney or cardiovascular causes) differed between age groups (HRs, 0.67 [95% CI, 0.52-0.87], 0.63 [0.4 8-0.82], and 0.89 [0.61-1.29] for ages <60, 60-69, and >_70 years, respectively; P = 0.3 for interaction) or sexes (HRs, 0.71 [95% CI, 0.5 4-0.95] and 0.69 [0.56-0.8 4] in women and men, respectively; P = 0.8 for interaction). No differences in safety outcomes by age group or sex were observed.Limitations: This was a post hoc analysis with multiple comparisons.Conclusions: Canagliflozin consistently reduced the relative risk of kidney events in people with diabetic kidney disease in both sexes and across age subgroups. As a result of greater background risk, the absolute reduction in adverse kidney outcomes was greater in younger participants.Funding: This post hoc analysis of the CREDENCE trial was not funded. The CREDENCE study was sponsored by Janssen Research and Development and was conducted collaboratively by the sponsor, an academic-led steering committee, and an academic research organization, George Clinical.Trial Registration: The original CREDENCE trial was registered at ClinicalTrials.gov with study number NCT02065791
Safety of hospital discharge before return of bowel function after elective colorectal surgery
- Author
- Aabling R R
- Aba M
- Abad-Motos A
- Abbasguliyev H
- Abdelgalil R
- Abdelhameed F
- Abdulrahman N
- Abdulrahman S M F
- Abdulrahman Z
- Abelevich A
- Abelló D
- Ablett A D
- Ablett A D
- Abrisqueta J
- Acherman Y I Z
- Adam A H
- Adamo V
- Adams S I B
- Adel A
- Adeleye O
- Adeusi L
- Adra M
- Aftab R
- Agarwal A
- Agarwal T
- Agca M H
- Aggiusti A
- Agresta F
- Aguilar J F Noguera
- Aguilar-Martínez M M
- Aguilera M L
- Aguilera M L
- Aguilera M L
- Ahmad H
- Ahmed A
- Ahmed H
- Ahmed K
- Ahmed M
- Ahmed M
- Ahmed S
- Ahmed W U R
- Ahmeidat A
- Ahsan S D
- Ainsworth P
- Aitken G
- Ajmera A
- Akay F E
- Akbani U
- Akbar Z
- Akbari K
- Akbari K
- Akhbari M
- Akın F A
- Akisheva A
- Akram B
- Aksoy A B
- Aksoy B
- Aksoy H
- Aktas M K
- Aktas M K
- Aktas M K
- Aktuna C
- Akyol C
- Al Zawawi S
- Al-Azzawi A
- Al-hadithi A
- Al-Salihi A
- Al-Saraff Z
- Al-Sarraf Z
- Alame Y J
- Alasmar M
- Alawattegama H
- Albayrak D
- Alberca-Paramo A
- Albert V
- Alconchel F
- Aldarragi A
- Alexander J
- Alhalabi O
- Ali A
- Ali A
- Ali Y
- Ali Z
- Alim Y E
- Aliosin O
- Aljohmani L
- Allen B
- Allen M
- Alm J
- Almeida J
- Almeida null
- Almeida P
- Almeida S
- Alonso B Campillo
- Alonso E Diego
- Alonso-Poza A
- Alqethami H J
- Alsaif A
- Alshakhs A
- Altiner S
- Altintas E
- Altomare D F
- Alvarez E
- Alvarez M Merayo
- Alves D
- Alves M
- Alves-Vale C
- Aly M H
- Amado A
- Amado F
- Amarnath T
- Amato R
- Ambrona-Zafra D
- Americano M
- Amey C
- Amico A
- Amicucci S
- Amini S
- Amiri S
- Amjad T
- Amor L González
- Amorim E
- Amorim E
- Anania G
- Anania M
- Anastasio L
- Anbarasan J
- Ancans G
- Anderson L
- Andolfi E
- Andrés C Blasco
- Andriola V
- Angeles P Vivas
- Angelini M
- Angelucci G P
- Angrisani M
- Anoldo P
- Antakia R
- Anthony-Uzoeto U
- Antona A D
- Antona F Blanco
- Antonakopoulos F
- Antonova T
- Antunes C Fidalgo
- Anwar H
- Aparício D J
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- Appleby E
- Aquilino F
- Archer J
- Aresu S
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- Argenti A Sgrò F
- Arias-Camisón P Livianos
- Arkadopoulos N
- Armellini A
- Arnold A
- Aromolaran O
- Arranz J M Nieto
- Arrocha J Duran
- Arroyo A
- Arslan E
- Arthur J
- Arthur T
- Artioli E
- Aru A C
- Ashworth I
- Ashworth I
- Asif A
- Asif A
- Atar C
- Athanasopoulos P G
- Atiyah A
- Attene F
- Aveiro D
- Avelino L
- Avendaño I Esteban
- Aversano A
- Awokoya O
- Aydin T
- Aykun N
- Ayllon H
- Aytin Y E
- Ayyar S
- Azevedo J
- Azzahhafi J
- Bacchion M
- Badhrinarayanan S
- Badran A
- Badran A
- Baggus E
- Bagnall M
- Baião J M
- Baird J
- Baki B E
- Balalis D
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- Baldassarre L
- Balestra F
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- Ballarini Z
- Balsamo F
- Banaz T
- Bandyopadhyay D
- Bansal N
- Baraghini M
- Baran T
- Barbadillo A Trujillo
- Barberis A
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- Bareh A
- Barina A
- Barkolias C
- Barkovskaya A
- Barnett R
- Baronio G
- Barrett A
- Bartnick A
- Bartoli A
- Bartoš M
- Basak A
- Basile E
- Basile R
- Basso S
- Başçavuş M
- Batanero E Alonso
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- Bautista O Anabitarte
- Bautista O Anabitarte
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- Bártolo J
- Beattie G
- Beck L
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- Begaj A
- Belia F
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- Bellmunt O Claramonte
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- Bellochi R
- Belluco C
- Belzunce-Capó J F
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- Benevento A
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- Bennett J
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- Beqiri S
- Berec S
- Bergara I Badiola
- Bergkvist D Julià
- Bernado I R
- Bernardes T C Sá F M
- Berry B
- Berti S
- Bertilone E
- Betancourth C F Campo
- Betge F
- Bettella A
- Bettencourt R
- Bevilacqua E
- Bevilacqua M
- Bhahirathan Y
- Bhahirathan Y
- Bhargava A
- Bharwada Y
- Bhatia S
- Bholah H
- Bhopal S
- Biancafarina A
- Biancafarina A
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- Bianco C
- Bilen C
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- Binbuga M
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- Birindelli A
- Birindelli A
- Birk J
- Bisagni P A G
- Bisgin T
- Bishop S
- Bissett I P
- Bitonti M F
- Biyiklioglu O
- Bjerke J
- Blackwood O
- Blanco-Colino R
- Blanco-Colino R
- Blanco-Colino R
- Blaser B
- Blaser B
- Blefari N D A
- Bloom I
- Bodrov D
- Bodur S
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- Boersma D
- Boev B
- Bofarid S
- Boh Z Y
- Bointas G
- Bojičić J
- Boland M
- Bolaños R E Licardie
- Bonati E
- Bondurri A
- Bonfante P
- Bonnet G
- Boon C L
- Borakati A
- Borakati A
- Borg C M
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- Borges F
- Borghi B
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- Borisova A
- Borisova A
- Borrow J L
- Bosch M
- Botelho C
- Botelho P
- Boulbadaoui A
- Bowers C
- Bowley D
- Bowman C
- Boyce L
- Boyle E
- Boys M Hardie
- Boztuğ C Y
- Braccio B
- Bradbury M
- Bradley E
- Brady R
- Brandao B D
- Brandsborg S
- Brandsborg S
- Brandsma A M
- Brayley J
- Brazitikou K Mészárosová E
- Brenna R
- Brescia A
- Brigand C
- Brignall R
- Britten-Jones P
- Brkljac M
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- Brooks L
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- Brown S
- Brown S
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- Bruce D
- Buari M
- Bucci A Fares
- Bucci L
- Buchanan E
- Buckland B
- Bugelli M
- Bugmann A
- Buick T
- Bujda M
- Bull N
- Burford C
- Burzic A
- Busby K
- Busuttil A
- Butt S
- Bylinski T
- Bønnerup K
- Caballero J Martínez
- Cabral F
- Cachia C
- Cahill R
- Cahya E
- Caiazzo A
- Calgaro M
- Calle M Pérez
- Calussi M
- Calzada M G
- Campagnaro T
- Campagnaro T
- Campanaro C
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- Campbell B
- Campbell C
- Campbell E
- Campbell L
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- Campos P Villarejo
- Camprubí E Alberch
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- Canales I Cifrián
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- Canonico G
- Canonico G
- Canotilho R
- Cantafio S
- Cañete-Gómez J
- Cañete-Manzanares J
- Capella V
- Caplan J
- Capote H
- Capote H
- Capozzolo A
- Cappellacci F
- Caraballo I González
- Caratão M
- Carbone F
- Carboni L
- Carden C
- Cardo J García
- Cardoso J
- Carey C
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- Caristo G
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- Carneiro C
- Carrington Z
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- Casaril A
- Casiraghi S
- Cassar J
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- Cavallina G
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- Ceccarelli G
- Ceccarelli G
- Ceccarelli G
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- Celik M
- Cengiz U
- Centeno A
- Cerasari S
- Cerdán C
- Ceresoli M
- Cerra C
- Cesmeli E
- Cevlik A D
- Ceylan C
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- Chadwick M
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- Charalabopoulos A
- Charalambides M
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- Chatterjee-Woolman S
- Chaudhry F A
- Chaudhury N
- Chauhan M
- Chauke J
- Chavez C Marcano
- Chechelnitskaya Y
- Chee S Y
- Chen J Y
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- Cheng J
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- Chetta N
- Cheung J
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- Chipeta C
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- Cholewa H
- Chong C
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- Chowdhary M
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- Chrapko P S
- Chrimes A
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- Christensen P
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- Christodoulou I M
- Christodoulou I M
- Christodoulou T
- Christy S
- Chrysoheris P
- Chrz K
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- Chu M
- Chu M
- Chu T S M
- Chua T H
- Chuang A
- Chung L
- Cianchi F
- Ciccioli E
- Cigognini M
- Cillara N
- Cinar E N
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- Cinza A M
- Cirillo B
- Cismasiu B
- Ciubotaru C
- Ciubotaru C I
- Ciurleo C
- Claassen L
- Claireaux H
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- Clarke R
- Claro M
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- Clay W
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- Clerc D
- Clerc D
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- Clerico G
- Clough R
- Cockburn L
- Coey J
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- Colangelo E
- Coletta D
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- Collado-Roura F
- Collett D
- Collins H
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- Colombo F
- Colombo F
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- Colon L F
- Comert D
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- Constansia R
- Conti C
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- Convill J
- Coomes A
- Coratti F
- Cordero M J Ramos
- Corino C
- Cornejo L Casaval
- Correia A M
- Correia D
- Correia J G
- Cosmi F
- Costa C
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- Costigan O
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- Coulter C
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- Cousins G
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- Cravano S
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- Cresswell B
- Crisp E
- Criswell T
- Cross G W V
- Cruccu A
- Cruz A
- Cruz G
- Ctercteko G
- Cuartango A Sagredo
- Cucinotta E
- Cuello E
- Cuicchi D
- Cuming T
- Cunha C
- Cunha M
- Cunha M F
- Cunha P
- Cunha R
- Curchod P
- Curletti G
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- Curran M
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- Curtis C
- Ćuk V M
- Ćuk V V
- Ćuk V V
- Çalar S N
- Çetin M F
- D'Alessio R
- D'Ambra L
- D'Ascanio F
- D'Errico U
- D'Souza J
- da Ponte I Borges
- da Silva B Ribeiro
- Dabab N
- Dahya D
- Dalsgaard P
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- Dalzell F
- Damgaard I
- Dansuk S
- Danys D
- Danzi M
- Das K
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- Davidson K
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- Davis P
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- Dawson A
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- de Andres Olabarria U
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- De Angelis M
- De Donno G
- de Gouberville M C Gordinou
- De Jesus M
- de la Cruz G
- De Lima H
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- De Luca E
- De Luca M
- de Manzoni Garberini A
- de Manzoni Garberini A
- De Marco P
- De Nardi P
- De Nisco C
- De Nisco C
- De Padua C
- De Palma G
- De Paola L
- De Prizio M
- de Quirós J T Morales Bernaldo
- De Rosa M
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- de Roy van Zuidewijn D
- De Santi G
- De Toma G
- Dean K
- Debiasio A
- Debono S
- Defriend D
- Degaetano D
- Deksnis D
- Del Basso C
- del Pozo Andrés E
- del Pulgar A Gómez
- Delaugere L P
- Delgado P Alberti
- Delibegovic S
- Delibegovic S
- Delibegovic S
- Delibegovic S
- Delorme M
- Delrio P
- Demarre K
- Demartines N
- Demirci Z S
- Demiroglu Y
- Demirtas B
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- Desmond B
- Devesa H
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- Dharni A
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- Di Candido F
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- Di Cintio A
- Di Marco F
- Di Mola F F
- Diago J Platero
- Diallo R
- Dias B
- Dias R
- Dieguez B
- Dimitriadis S
- Dimitrov D
- Dimitrov V
- Dimov R
- Dindyal S
- Dingemans S A
- Dinger T L
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- Dixon M
- Dixon O
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- Diz A M Estévez
- Díaz N Ramayo
- Djeugam B
- Do J
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- Donaldson C
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- Dörr-Harim C
- Drane A
- Drungilas M
- Drury D J
- Duarte M
- Duarte M
- Dubovský M
- Duchalais E
- Duchalais E
- Duchalais E
- Duchalais E
- Dulskas A
- Dumange E
- Dunmore C
- Durdevic S
- Dworkin A
- Dwyer-Hemmings L
- Dyer A H
- Eames S
- Ede C
- Edwards S
- Eftychiou S
- Ehlern F
- Eiró F
- Eiró F
- Eismontas V
- Ekci B
- El Kasmi Y El Kasmy
- El Kasmi Y El Kasmy
- El Kasmi Y El Kasmy
- Elbayouk A
- Elliott D
- Embury-Young Y
- Emin A
- Emmertsen K J
- Enevoldsen M
- English C
- English W J
- Enriquez-Navascues J M
- Eow S Y
- Epanomeritakis E
- Epton S
- Eray I C
- Erdas E
- Erdas E
- Erdem M
- Erdönmez H
- Eren E
- Erichsen S B
- Erotocritou M
- Erten V
- Escoll J
- Escovar F Jiménez
- Espin-Basany E
- Espin-Basany E
- Esposito L M
- Estalagem I
- Evans C
- Evans E
- Evans H
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- Facundo H Gómez
- Fadipe T
- Fafemi O
- Fagan P V B
- Fagan P V B
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- Fairfield C J
- Fakim B
- Fakirullahoglu M
- Falco N
- Falsetti E
- Famularo S
- Fanibi B
- Faqihinejad C
- Farhan-Alanie M M H
- Farhan-Alanie M M H
- Farik S
- Farina V
- Farooq H
- Farrow F
- Faulkner G
- Faustino A
- Fazzi K
- Fearnhead N
- Federico N S Pipitone
- Federico N S Pipitone
- Feleppa C
- Felipe B Ricardo
- Feliz J Medina
- Fenn S
- Feradova H
- Fernandes V
- Fernandez A
- Fernández M Calvo
- Fernández P
- Fernández-Vega L
- Feroci F
- Ferrara F
- Ferrara F
- Ferrari C
- Ferrari C
- Ferrández M Rico
- Ferreira A S
- Ferreira M
- Ferreira M
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- Fialho G
- Fico V
- Figà F
- Figueras R Vives
- Finch B J
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- Findlay J M
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- Finotti E
- Fioriti C
- Fisher P
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- Fleischl W
- Fleres F
- Flint E J
- Flores M
- Fomin I
- Fonseca S
- Fontani A
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- Foppa C
- Ford V
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- Forero-Torres A
- Forero-Torres A
- Forero-Torres A
- Foschi D
- Frade S
- Fradley W
- Fragoso M
- Franceschi A
- Franceschi A
- Francis A A
- Francis A A
- Francisco V
- Franco M
- Frangella F
- Franssen R J M
- Franssen S
- Frasson M
- Frattalone M
- Freire L
- Frey P E
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- Frezza B
- Frostick R
- Fung A
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- Gabarski A
- Gabbas G
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- Gabriel M
- Gadhvi A
- Gaetano P
- Gagliardi B
- Gagliardi B
- Gailumsis R
- Galata C
- Galeano C Uribe
- Galgano A
- Galiffa G
- Gallagher C
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- Galleano R
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- Gallo G
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- Garcea A
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- Garcia A
- Garcia J M
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- Gemini A
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- Gennai A
- Genzano C
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- Giamundo P
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- Giannella A
- Gibbins A
- Giglio M
- Gil A
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- Gilani M
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- Gilliam A
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- Giovannini F
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- Gramlick M
- Grandi S
- Grant R
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- Green C
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- Griffiths N
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- Grimaldi L
- Grottola T
- Grüter A
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- Guarinos C V Pérez
- Gubbiotti F
- Guerreiro A
- Guerreiro I
- Guerreiro I
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- Guglielmi A
- Guimarães J
- Guimarães N
- Guner A
- Gurjar S
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- Gurung B
- Gusai G P
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- Güldag A
- Güner B
- Gürsoy F
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- Haji A
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- Henkens A
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- Hernández L C García
- Hernon J
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- Herron J
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- Hotchkies A
- Houdek O
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- Hunt G
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- Hurný M Hanušová M
- Husain S
- Hussain M
- Hübner M
- Hylands A
- Ibrahim B
- Ibrahim I
- Idoate C Pastor
- Ike S I
- Iliev S
- Ilieva I
- Illahi M
- Illera M V Fernandez
- Imadalou L
- Imam L
- Impellizzeri H
- Impellizzeri H
- Imperatore M
- Imtiaz M
- Inama M
- Incollingo P
- Ioannidis A
- Ioannidis A
- Ipor A
- Iqbal R
- Iqbal Z
- Irwin E
- Isabello A
- Isik A
- Isik A E
- Isik K
- Iskan N G
- Isler V C
- Isse M
- ItSURG null
- Ivanov T
- Ivanov V
- Ivanov V
- Izzarina A
- İşlek E C
- Jackson A
- Jackson L
- Jacobson A
- Jaffer T
- Jaich R
- Jaich R
- Jain A
- Jain C
- Jakubauskas M
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- Jamal M
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- Serin H
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- Serra D
- Serra M L
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- Serralvo A De La Llave
- Sewart E
- Sexmero M J Mateos
- Shaban F
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- Sharriff H
- Shashidhara A
- Sheikh Z
- Shirazi B
- Shishkin B
- Shortland T C
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- Shoshkova M
- Shrestha S
- Sierra J E
- Silva A
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- Simcikas D
- Simcikas D
- Simioni A
- Simioni A Sgrò A
- Simioni A Sgrò A
- Simon S C S
- Simó M Romero
- Simões J
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- Singh A
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- Sinha S
- Sinibaldi G
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- Sinovas O Esteban
- Sisley M
- Siva S
- Sivarajah S
- Sivinš A
- Skalický A
- Skalický P
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- Skan O
- Skavysh A
- Skejø C D
- Skipworth C
- Skull A
- Slepavicius A
- Slimbajevs T
- Sliwinski S
- Slooter G
- Sloper W
- Sloper W
- Sluijpers N R F
- Smart N J
- Smillie R
- Smit M P C M
- Smith B
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- Smith E
- Smith F M
- Smolarek S
- Soare C
- Soares A
- Soares A Sgrò A
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- Soares D
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- Soldevila-Verdeguer C
- Solomou G
- Soma A
- Soman S
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- Sotona O
- Sousa M
- Sousa X
- Southgate A
- Söyleyici B
- Sparke A
- Sparta C
- Spartalis E
- Spaziani A
- Spazzapan M
- Speake D
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- Stahl J
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- Stainer B
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- Steinle J
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- Stijns R C H
- Stommel M W J
- Storm M
- Stroud R
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- Strupas K
- Stubbs B
- Stylianides N
- Suarez-Sanchez M
- Subramanian I
- Sucameli F
- Sucháň P K
- Suchdev N
- Suchett-Kay I
- Suchett-Kaye I
- Sunal A
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- Suresan S
- Suresh G
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- Surgo D
- Swamad M
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- Sysum K
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- Tabibi M
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- Talamo G
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- Taleongpong P
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- Tamosiunas A
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- Tan R
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- Taneja S
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- Tanvir T
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- Tasdelen I
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- Taylor N
- Tazza G
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- Teeling F
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- Teixeira H
- Telford K
- ten Doesschate S F H
- ten Doesschate S F H
- Tenconi S M
- Terricabras S Rifà
- Testa V
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- Tew Z Yi
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- Tewhaiti-Smith J
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- Thakral N
- Thakrar C
- Thakrar C
- Thakrar V
- Thavayogan R
- Thavayogan R
- Thãwel T
- Theocharidou L
- Theodoraki G
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- Toh C
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- Torrance A
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- Xiao Y
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- Yanikoglu E
- Yanishev A
- Yanishev A
- Yanishev A
- Yarenci E
- Yasin I H
- Yasin I H
- Yassaie S
- Yassaie S S
- Yavas M
- Yavuz G
- Yeap B
- Yebes A
- Yebes A
- Yelkenci C
- Yeni M
- Yeo Y Q
- Yeoh T
- Yesilsancak M
- Yildirak M K
- Yildirim N
- Yilmaz D
- Yilmaz D
- Yilmaz I
- Yılmaz M
- Yilmaz S
- Yiu J
- Yong S Q
- Yoong A
- Yotsov T
- Young J
- Youssef H
- Youssef Y
- Yu N
- Yuksek A
- Yumurtaci Ö
- Yurdaor S S
- Yurdaor S S
- Yusuf Z
- Yüksek B
- Yüksek B
- Zaffaroni G
- Zaidi A
- Zalla T
- Zaman S
- Zamzow K
- Zardab M
- Zearmal S
- Zeb E
- Zegarra E D Padilla
- Zeromskas P
- Zeynalov F
- Zhao J
- Zhao S
- Zheng S
- Zhu L Y
- Zoikas A
- Zoikas A
- Zubowicz M
- Zuin M
- Zulkefley N
- Žebrák M Farkašová R
- Žebrák R
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Background Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function. Methods A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The main outcome of interest was readmission to hospital within 30 days of surgery. The impact of discharge timing according to the return of bowel function was explored using multivariable regression analysis. Other outcomes were postoperative complications within 30 days of surgery, measured using the Clavien-Dindo classification system. Results A total of 3288 patients were included in the analysis, of whom 301 (9 center dot 2 per cent) were discharged before the return of bowel function. The median duration of hospital stay for patients discharged before and after return of bowel function was 5 (i.q.r. 4-7) and 7 (6-8) days respectively (P < 0 center dot 001). There were no significant differences in rates of readmission between these groups (6 center dot 6 versus 8 center dot 0 per cent; P = 0 center dot 499), and this remained the case after multivariable adjustment for baseline differences (odds ratio 0 center dot 90, 95 per cent c.i. 0 center dot 55 to 1 center dot 46; P = 0 center dot 659). Rates of postoperative complications were also similar in those discharged before versus after return of bowel function (minor: 34 center dot 7 versus 39 center dot 5 per cent; major 3 center dot 3 versus 3 center dot 4 per cent; P = 0 center dot 110). Conclusion Discharge before return of bowel function after elective colorectal surgery appears to be safe in appropriately selected patients