Tese de doutoramento em Biologia (Biologia do Desenvolvimento), apresentada à Universidade de Lisboa através da Faculdade de Ciências, 2008Fundação para a Ciência e Tecnologia (FCT), (SFHR/BD/10035/2002

Silva, Ana Cristina Guerra Matos Ferreira da, 1979-

Universidade de Lisboa: Repositório.UL

English

A monomeric red fluorescent protein.

A new technique for the cultivation of the chick embryo in vitro.

A series of normal stages in the development of the chick embryo.

Activin/Nodal responsiveness and asymmetric expression of a Xenopus nodal-related gene converge on a FAST-regulated module in intron 1.

Antagonistic signaling by Caronte, a novel Cerberus-related gene, establishes left-right asymmetric gene expression.

Anterior neural plate regionalization in cripto null mutant mouse embryos in the absence of node and primitive streak.

Asymmetric expression of antivin/lefty1 in the early chick embryo.

BMP signaling positively regulates Nodal expression during left right specification in the chick embryo.

BMP2 is a positive regulator of Nodal signaling during left-right axis formation in the chicken embryo.

Bmp4 plays a key role in left-right patterning in chick embryos by maintaining Sonic Hedgehog asymmetry.

Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann’s organizer.

Cerberus regulates left-right asymmetry of the embryonic head and heart.

Cerberus-like is a secreted BMP and Nodal antagonist not essential for mouse development.

Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula.

Characterization of human FAST-1, a TGFbeta and activin signal transducer.

Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2.

Distinct transcriptional regulation and phylogenetic diversity of human LEFTY genes.

Efficient selection for highexpression transfectants with a novel eukaryotic vector.

Endogenous patterns of BMP signaling during early chick development.

Establishment of vertebrate left-right asymmetry.

Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis.

Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system.

Identification of an element within the promoter of human selenoprotein P responsive to transforming growth factor-beta.

Left–right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2.

Left–right patterning of the mouse lateral plate requires nodal produced in the node.

Manipulating the Mouse Embryo: A Laboratory Manual.

MatInd and MatInspector – New fast and versatile tools for detection of consensus matches in nucleotide sequence data.

Morpholino and phosphorothioate antisense oligomers compared in cell-free and in-cell systems.

Murine Cerberus homologue mCer-1: a candidate anterior patterning molecule.

Nodal signaling in the epiblast patterns the early mouse embryo.

Nodal signaling in vertebrate development.

Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate.

Nodal signalling in vertebrate development.

Nodal stability determines signaling range.

Normal Table of Xenopus laevis (Daudin).

Pitx2, a bicoid type homeobox gene, is involved in a Lefty-signaling pathway in determination of left–right asymmetry.

Reconciling different models of forebrain induction and patterning: a dual role for the hypoblast.

Roles of nodal-lefty regulatory loops in embryonic patterning of vertebrates.

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptorlike kinase (ALK) receptors ALK4, ALK5, and ALK7.

Smad2 signalling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo.

SPC4/PACE4 regulates a TGFbeta signaling network during axis formation.

Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.

The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis.

The Cerberus/Dan-family protein Charon is a negative regulator of Nodal signalling during left-right patterning in zebrafish.

The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals.

The hypoblast of the chick embryo positions the primitive streak by antagonizing nodal signaling.

The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry.

The regulation of myogenin gene expression during the embryonic development of the mouse.

The transfer of left-right positional information during chick embryogenesis.

The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities.

The zebrafish nodal-related gene southpaw is required for visceral and diencephalic left-right asymmetry.

Two-step regulation of left–right asymmetric expression of Pitx2: initiation by nodal signaling and maintenance by Nkx2.

Unveiling the establishment of left–right asymmetry in the chick embryo.

Xenopus frizzled 7 can act in canonical and non-canonical Wnt signaling pathways: implications on early patterning and morphogenesis.

Molecular analysis of anterior endoderm during Xenopus development: a funtional and genomic approach