2 research outputs found
<i>In Vitro</i> Dissolution, Cellular Membrane Permeability, and Anti-Inflammatory Response of Resveratrol-Encapsulated Mesoporous Silica Nanoparticles
Sizing
drugs down to the submicron and nanometer scale using nanoparticles
has been extensively used in pharmaceutical industries to overcome
the poor aqueous solubility of potential therapeutic agents. Here,
we report the encapsulation and release of resveratrol, a promising
anti-inflammatory and anticancer nutraceutical, from the mesopores
of MCM-48-type silica nanospheres of various particle sizes, i.e.,
90, 150, and 300 nm. Furthermore, the influence of the carrier pore
size on drug solubility was also evaluated (3.5 vs 7 nm). From our
results, it is observed that the saturated solubility could depend
not only on the pore size but also on the particle size of the nanocarriers.
Moreover, with our resveratrol-mesoporous silica nanoparticles formulation,
we have observed that the permeability of resveratrol encapsulated
in MCM-48 nanoparticles (90 nm) can be enhanced compared to a resveratrol
suspension when tested through the human colon carcinoma cell monolayer
(Caco-2). Using an <i>in vitro</i> NF-κB assay, we
showed that resveratrol encapsulation did not alter its bioactivity
and, at lower concentration, i.e., 5 μg mL<sup>–1</sup>, resveratrol encapsulation provided higher anti-inflammatory activity
compared to both resveratrol suspension and solution. All combined,
the reported results clearly highlight the potential of small size
mesoporous silica nanoparticles as next generation nanocarriers for
hydrophobic drugs and nutraceuticals
Stepwise Pore Size Reduction of Ordered Nanoporous Silica Materials at Angstrom Precision
A facile
vacuum-assisted vapor deposition process has been developed
to control the pore size of ordered mesoporous silica materials in
a stepwise manner with angstrom precision, providing an unprecedented
paradigm for screening a designer hydrophobic drug nanocarrier with
optimized pore diameter to maximize drug solubility