The combination of letrozole and metformin has a better therapeutic effect on uterine and ovarian arteries in PCOS patients

BackgroundPolycystic ovary syndrome (PCOS) is the most prevalence endocrine disorder in the reproductive age of women. In these patients, medications such as clomiphene citrate, letrozole and metformin are used to induce ovulation and overcome infertility.AimsThis study was done for comparing the findings of Color Doppler sonography of the uterine and ovarian arteries in women with PCOS under treatment of two drug groups of letrozole-metformin and clomiphene-metformin.Methods Intervention-applied study was performed on 108 women with secondary infertility due to PCOS in Imam Reza Hospital of Kermanshah in 2016. Women were divided in two groups of 54 people, for investigating the effect of letrozole-metformin and clomiphene-metformin on ovarian and uterine arteries.Results Blood flow in the uterus and ovaries significantly increased after treatment with letrozole-metformin and clomiphene-metformin (P < 0.05). However, the effect of letrozole-metformin was significantly higher than that of clomiphene-metformin on uterine and ovarian arteries Resistance Index (RI) (P < 0.05).ConclusionLetrozole-metformin as well as clomiphene-metformin have a significant effect on blood flow in the uterus and ovaries. The group which received letrozole-metformin had a better response in this regard