Monitoring and Back-Analysis in Dongjian Arch Dam

The monitoring of displacement is one of major measures to ensure the safety of an arch dam. And the back-analysis is a key link in the safety evaluation. This paper presents a case history of monitoring and back-analysis of displacement in Dongjiang Arch Dam, China. The elasticity modulus of dam foundation were determined by back-analysis of displacement for lower water level in the reservoir. The prediction of displacement of dam was compared with the results of monitoring. The suggested procedure of 3D finite element computation coupling solid and temperature stresses can be used for other types of rock engineering

A spatiotemporal atlas of cholestatic injury and repair in mice

<p>Cholestatic injuries, characterized by regional damage around the periportal region, lack curative therapies and cause considerable mortality. In this study, we generated a high-definition spatiotemporal atlas during cholestatic injury and repair by Stereo-seq and single-cell transcriptomics. We uncovered that cholangiocytes function as a periportal hub (cholangio-hub) by integrating multiple signals with neighboring cells. Feedback between cholangiocytes and lipid-associated macrophages (LAM) was detected in the cholangio-hub, which is related to the differentiation of LAM, a recently identified subpopulation of macrophages crucial in tissue injury. Moreover, the cholangio-hub highly expressed TGFβ, which is associated with cholangiocyte conversion of liver progenitor-like cells during injury and dampened proliferation of periportal hepatocytes during recovery. Importantly, spatiotemporal analysis revealed a key inhibitory rheostat for hepatocyte proliferation. Our data provide a comprehensive resource for demarcating regional cholestatic injuries.</p&gt