1 research outputs found
Hepatoprotective activity of <i style="mso-bidi-font-style:normal">Oxalis corniculata</i> L. ethanolic extract against paracetamol induced hepatotoxicity in Wistar rats and its <i style="mso-bidi-font-style:normal">in vitro</i> antioxidant effects
147-152Oxalis
corniculata is well known for its medicinal
properties like anti-inflammatory, digestive, diuretic, antibacterial,
antiseptic etc. The present study focuses on the ability of O. corniculata to alleviate liver damage
caused by over dose of paracetamol. Antioxidant activity of O. corniculata was evaluated using the
free radical scavenging activity of 1,
1-diphenyl-2- picrylhydrazyl radicals, total anti oxidant capacity by
phosphomolybdenum method and total phenolic content was also evaluated. The
ethanolic extract of whole plant of O.
corniculata (OC, 500 µg/mL, po) significantly reduced 1,
1-diphenyl-2- picrylhydrazyl radicals. This dose also caused significant
reduction (62.67%) in malondialdehyde levels of murine hepatic tissues. The antioxidant
capacity of OC was comparable to that of standard ascorbic acid and showed
53.5 µg of phenol/mg OC. Rats pre-treated with OC
for 4 days showed significant reduction in the serum enzymes such as glutamate
oxaloacetate transaminase, glutamate pyruvate transaminase, alkaline
phosphatase, serum bilirubin and showed almost normal histological liver
architecture of the treated groups compared to paracetamol induced hepatic
damage group, indicating its hepatoprotective and antioxidant potential