Droit de l’internet : droit français et européen (2ème éd.)

<p>Forest plot showing the meta-analysis outcomes of the effect of CP/CPPS on sperm vitality.</p

The Effect of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) on Semen Parameters in Human Males: A Systematic Review and Meta-Analysis

<div><p>Background</p><p>Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is one of the risk factors of impaired male fertility potential. Studies have investigated the effect of CP/CPPS on several semen parameters but have shown inconsistent results. Hence, we performed a systematic literature review and meta-analysis to assess the association between CP/CPPS and basic semen parameters in adult men.</p><p>Methods</p><p>Systematic literature searches were conducted with PubMed, EMBASE and the Cochrane Library up to August 2013 for case-control studies that involved the impact of CP/CPSS on semen parameters. Meta-analysis was performed with Review Manager and Stata software. Standard mean differences (SMD) of semen parameters were identified with 95% confidence intervals (95% CI) in a random effects model.</p><p>Results</p><p>Twelve studies were identified, including 999 cases of CP/CPPS and 455 controls. Our results illustrated that the sperm concentration and the percentage of progressively motile sperm and morphologically normal sperm from patients with CP/CPPS were significantly lower than controls (SMD (95% CI) −14.12 (−21.69, −6.63), −5.94 (−8.63, −3.25) and −8.26 (−11.83, −4.66), respectively). However, semen volume in the CP/CPPS group was higher than in the control group (SMD (95% CI) 0.50 (0.11, 0.89)). There was no significant effect of CP/CPPS on the total sperm count, sperm total motility, and sperm vitality.</p><p>Conclusions</p><p>The present study illustrates that there was a significant negative effect of CP/CPPS on sperm concentration, sperm progressive motility, and normal sperm morphology. Further studies with larger sample sizes are needed to better illuminate the negative impact of CP/CPPS on semen parameters.</p></div

Forest plot showing the meta-analysis outcomes of the effect of CP/CPPS on semen volume.

<p>Forest plot showing the meta-analysis outcomes of the effect of CP/CPPS on semen volume.</p

Forest plot showing the meta-analysis outcomes of the effect of CP/CPPS on sperm total motility.

<p>Forest plot showing the meta-analysis outcomes of the effect of CP/CPPS on sperm total motility.</p

Characteristics of included studies investigating the effect of CP/CPPS on semen parameters.

<p>Abbreviations: SpV, semen volume; SC, sperm concentration (density); TSC, total sperm count; SPM, progressive sperm motility; STM, total sperm motility; SpV, sperm vitality; SNM, normal sperm morphology; IIIA, NIH IIIA subgroup; IIIB, NIH IIIB subgroup; III, NIH III subgroup; NI, not indicated in studies;</p>a<p>: confirmed by the authors.</p

Flow diagram of selection of eligible studies.

<p>Flow diagram of selection of eligible studies.</p

Forest plot showing the meta-analysis outcomes of the effect of CP/CPPS on total sperm counts.

<p>Forest plot showing the meta-analysis outcomes of the effect of CP/CPPS on total sperm counts.</p