1 research outputs found
Host–Guest Chemistry of Dendrimer–Cyclodextrin Conjugates: Selective Encapsulations of Guests within Dendrimer or Cyclodextrin Cavities Revealed by NOE NMR Techniques
In this study, G5 PAMAM dendrimer and α-, β-,
γ-cyclodextrin
(CD) conjugates were synthesized. Host–guest behaviors of the
conjugates toward five guest molecules including sodium methotrexate
(MTX), amantadine hydrochloride (ADH), sulfamethoxazole (SMZ), sodium
deoxycholate (SDC), and sodium dodecyl sulfate (SDS) were analyzed
by NOE NMR techniques. Among the five guest molecules, ADH only binds
with β-CD in G5−β-CD, SDC shows higher priority
to localize within the cavity of γ-CD in G5−γ-CD,
while MTX exhibits selective encapsulation within the cavities of
G5 dendrimer in G5−α-CD. SDS has high binding affinity
with α-CD in G5−α-CD but forms a precipitate in
the complex solution. SMZ shows simultaneous encapsulation within
CDs (α-, β-, and γ-CD) or G5 in the presence of
the three conjugates. The host behavior of G5–CD conjugates
depends on CD cavity size, guest size, and hydrophobicity. The results
obtained in this study are helpful in the optimization of dendrimer–CD
conjugate-based drug delivery systems