Assessing the Impact of Prophylactic Eculizumab on Renal Graft Survival in Atypical Hemolytic Uremic Syndrome

Background: Atypical hemolytic uremic syndrome (aHUS) is a rare cause of end-stage kidney disease and associated with poor outcomes after kidney transplantation from early disease recurrence. Prophylactic eculizumab treatment at the time of transplantation is used in selected patients with aHUS. We report a retrospective case note review describing transplant outcomes in patients with aHUS transplanted between 1978 and 2017, including those patients treated with eculizumab. / Methods: The National Renal Complement Therapeutics Centre database identified 118 kidney transplants in 86 recipients who had a confirmed diagnosis of aHUS. Thirty-eight kidney transplants were performed in 38 recipients who received prophylactic eculizumab. The cohort not treated with eculizumab comprised 80 transplants in 60 recipients and was refined to produce a comparable cohort of 33 transplants in 32 medium and high-risk recipients implanted since 2002. Complement pathway genetic screening was performed. Graft survival was censored for graft function at last follow-up or patient death. Graft survival without eculizumab treatment is described by complement defect status and by Kidney Disease: Improving Global Outcomes risk stratification. / Results: Prophylactic eculizumab treatment improved renal allograft survival (P = 0.006) in medium and high-risk recipients with 1-y survival of 97% versus 64% in untreated patients. Our data supports the risk stratification advised by Kidney Disease: Improving Global Outcomes. / Conclusions: Prophylactic eculizumab treatment dramatically improves graft survival making transplantation a viable therapeutic option in aHUS

An Analytical Study of Option Greeks on Derivative Markets in India

About the Book: Each chapter of this book assesses the extent to which investors might be affected by specific risks of emerging markets, and how they can manage it. The studies include a range of different countries including India, Pakistan, Poland and Morocco, and provide interesting results that have important implications for pricing of securities and investor strategy. Table of contents Introduction; S.Motamen-Samadian * Risky Production and Hedging in Emerging Markets; O.Jokung * An Analytical Study of Option Greeks on Derivative Markets in India; D.G.Kodwani * Global Asset Allocation: Risk and Return on Emerging Stock Markets; M.Derrabi & M.Leseure * Informational Efficiency in Emerging Markets: A Case of Random Walk in the Karachi Stock Exchange; O.Gough & A.Malik * Insiders' Market Timing and Real Activity: Evidence from an Emerging Market; T.P.Winsiewski * Trading Risk Management: Practical Applications to Emerging Markets; M.A.M.Al Janabi * Value at Risk: Does it Work in Emerging Markets?; C.Yu, B.Davidson & M.Nurullah