SU(N) Quantum Hall Skyrmions

We have investigated skyrmions in N-component quantum Hall systems. We find that SU(N) skyrmions are the lowest energy charged excitations for filling factors \nu = 1,2,...,N-1 for small enough symmetry breaking terms. N>2 skyrmions can be realized in Si QH systems based on the (110) or (111) interfaces of Si, or perhaps in Si (100) systems, where the spin and valley isospin together provide an SU(4)-symmetry, or in multilayer QH systems. We also present Hartree-Fock results for a phenomenological easy-axis SU(2)-breaking model appropriate to valley degeneracy.Comment: 5 pages, 2 figure

Synthesis of biologically active novel <i style="">bis</i> Schiff bases, <i style="">bis </i>hydrazone and <i style="">bis </i>guanidine derivatives

1128-1136A number of bis Schiff′s bases 3a-d have been synthesized by condensation of 2,4,8,10 tetraoxaspiro[5,5]undecane 3,9-dipropanamine 1 with furfural, indole-3-aldehyde, 2-acetylpyridine, 4-acetylpyridine and 5a-c by condensation of 1,4-bis (3-aminopropyl) piperazine 4 with indole-3-aldehyde, 2-acetylpyridine, 4-acetylpyridine, in high yields by using microwave irradiation. Bis hydrazone derivatives 8a-c are obtained by condensation of 2,6-diacetylpyridine 7 with various arylsulfonylhydrazides using microwave irradiation. A number of bis guanidine derivatives 11a-j are synthesized by condensation of 1,3-diaminoguanidine monohydrochloride 10 with various aldehydes 9a-c and ketones 9d-j. The structures assigned to these purified compounds i.e 3a-d, 5a-c, 8a-c, and 11a-j, are supported by correct spectral data and elemental analysis. Anti-inflammatory activities of 3b and 11e are comparable to standard drug phenyl butazone. Analgesic activities of 11e and 3b are compared with phenyl butazone and 3b showed better activity then phenyl butazone

Microwave assisted synthesis of indole and furan derivatives possessing good anti-inflammatory and analgesic activity

1848-1854Indole-2-carboxylic acid on condensation with benzene sulfonyl hydrazide and p-toluene sulfonyl hydrazide gives condensation products 1a and 1b. 1H-Tetrazole-5-acetic acid, hydantoin-5-acetic acid, orotic acid, 5-bromo nicotinic acid and indole 2-carboxylic acid have been condensed with furfuryl amine to give corresponding condensation products 2a-e whereas condensation of succinic acid and adipic acid with furfuryl amine gives products 3a and 3b respectively. 3,5-Pyrazole dicarboxlic acid, 4,5-imidazole dicarboxylic acid and 3-carboxy-1,4-dimethyl pyrole-2-acetic acid on condensation with furfuryl amine give compounds 4, 5 and 6. All these compounds i.e. 1a,b, 2a-e, 3a,b, 4, 5 and 6 have been characterized by spectroscopic means and have been screened for anti-inflammatory and analgesic activity. Compounds 2a, and 5 exhibit good anti-inflammatory and 2a, 2c and 5 exhibit good analgesic activity

ChemInform Abstract: Microwave Assisted Synthesis of Indole and Furan Derivatives Possessing Good Antiinflammatory and Analgesic Activity.

1848-1854Indole-2-carboxylic acid on condensation with benzene sulfonyl hydrazide and p-toluene sulfonyl hydrazide gives condensation products 1a and 1b. 1H-Tetrazole-5-acetic acid, hydantoin-5-acetic acid, orotic acid, 5-bromo nicotinic acid and indole 2-carboxylic acid have been condensed with furfuryl amine to give corresponding condensation products 2a-e whereas condensation of succinic acid and adipic acid with furfuryl amine gives products 3a and 3b respectively. 3,5-Pyrazole dicarboxlic acid, 4,5-imidazole dicarboxylic acid and 3-carboxy-1,4-dimethyl pyrole-2-acetic acid on condensation with furfuryl amine give compounds 4, 5 and 6. All these compounds i.e. 1a,b, 2a-e, 3a,b, 4, 5 and 6 have been characterized by spectroscopic means and have been screened for anti-inflammatory and analgesic activity. Compounds 2a, and 5 exhibit good anti-inflammatory and 2a, 2c and 5 exhibit good analgesic activity

Synthesis of biscoupled hemin-thiazoline derivatives and their anticancer activity evaluation

162-167A number of biscoupled hemin-thiazoline derivatives 3a-i have been synthesized and screened in vitro against six human cancer cell lines consisting of lung large (NCIH460), colon (HT29), breast (MCF7 and MCF7/ADR), prostate (DU 145) and CNS (U251) tumors. Compound 3e exhibits good anticancer activity against lung large (NCIH460; GI50 4.3MM), where compound 3g shows good anti cancer activity against colon (HT29; GI50 0.9 μM), breast (MCF7; GI50 0.5μM; MCF7/ADR; GI50 1.8μM), prostate (DU 145; GI50 1.6μM) and CNS (U251; GI50 2.5μM) tumors

Synthesis and anticancer activity evaluation of some hemin and hematoporphyrin derivatives

388-393Sulphamerazine, sulphadiazine, and sulphaguanidine are coupled with hemin to give bis coupled products 1a, 1b and 1c respectively. 3, 4-Diphenyliminothiazoline, sulphamerazine, sulphaacetamide, sulphathiazole and sulphadiazine on coupling with hematoporphyrin give bis coupled products 2a, 2b, 2c, 2d and 2e respectively. Compounds 1a-c and 2a-e have been screened for anticancer activity against a small panel of six cancer cell lines consisting of prostate(DU 145), colon (HT29), melanoma (LOX), breast(MCF7 and MCF7/ADR) and CNS(U251) tumors. Best GI50 (concentration which inhibits the cell growth by 50%) values are shown by 2c, 2.2μM(prostate tumor, cell line DU145); 2c 13.0μM(colon tumor, cell line HT29); 2b, 3.4μM(melanoma tumor, cell line LOX); 2c, 9.7μM(breast tumor, cell line MCF7); 2a, 3.1μM(breast, tumor, cell line MCF7/ADR) and 1c, 3.4μM(CNS tumor, cell line U251) respectively. Out of all the compounds reported here GI50 value shown by 2a i.e.3.1μM against breast, tumor (MCF7/ADR) is quite close to the GI50 value i.e. 1.8μM, of standard drug doxorubicin

Horseradish peroxidase catalyzed and electrochemical oxidations of 2-thiouracil — A comparison

463-468Horseradish peroxidase (type VIII) catalyzed and electrochemical oxidations of 2-thiouracil have been studied in phosphate buffer of pH 7.20 (μ==1.0 M) at an ambient temperature of 25±2°C. The peroxidase catalyzed oxidation has been initiated by using hydrogen peroxide and electrooxidation carried out at pyrolytic graphite electrode. The UV-absorbing intermediates generated in both the oxidations have been characterized by voltammetry, spectrophotometry and by kinetics of decay and are found identical. Products of enzymic and electrochemical oxidations have been characterized by using GCMS stuides. A tentative redox scheme has been proposed for the enzymic oxidation of 2-thiouracil and compared with that of electrooxidation and has also been found similar. Thus, it has been concluded that oxidation of 2-thiouracil by enzymic and electrochemical methods are, in a chemical sense, identical

Synthesis and anti-inflammatory activity evaluation of some sulfonamide and amidine derivatives of 4-aryl-3-(2 or 4-picolyl)-2-imino-4-thiazolines

1076-1082Condensation of 2- and 4-picolylaminehydrochloride 2a,b with (un) substituted phenacylthiocyanate 1a-d gives 4-aryl-3-(2- or 4-picolyl)-2-imino-4-thiazolines 3a-h in moderate yields. Sulfonamide derivatives 4a-h have been synthesized by condensation of 4-aryl-3-(2- or 4-picolyl)-2-imino-4-thiazolines 3a-h with methanesulfonylchloride in good yields. Condensation of 2-cyanopyridine with thiazolines 3a, 3e and of 4-cyanopyridine with 3a, c, e and h gives amidine derivatives 5a, b and 6a-d respectively. Thiazoline derivatives 3a-h, sulfonamide derivatives 4a-h and amidine derivatives 5a, b; 6a-d are characterized by IR, 1H NMR, GC-MS spectral data and elemental analysis. Anti-inflammatory activity evaluation of 3a-h, 4a-d, g-h, 5a,b and 6a-c using carageenan induced paw oedema assay at 50 mg/kg p.o. has been carried out and compound 6a exhibited anti-inflammatory activity comparable to standard drug ibuprofen

Synthesis, anti-inflammatory and analgesic activity evaluation of some pyrimidine derivatives

273-281A number of pyrimidine derivatives 1-3, 5-19 have been synthesized by condensation of bis(2-(vinyloxy))ethylamine, cyclopropylamine, N-(2-amino-4-ethoxyphenyl)acetamide, 2-(aminomethyl thiophene), 2-thiophen ethylamine, 2-hydrazinopyridine, 1-aminonaphthalen-2-ol hydrochloride, furfuryl amine, 2-(4-imidazolyl)ethylamine, 2-picolylamine and 4-methoxyl-2-nitroaniline with various isothiocyanatoketones. These compounds have been screened for anti-inflammatory and analgesic activities. Compounds 10 and 14 have exhibited 40% and 39% anti-inflammatory and compound 11 has showed 75% analgesic activity at 100 mg/kg p.o. respectively