PTSA CATALYZED KSF SOLID SUPPORTED MICHAEL ADDITION ON STYRYLISOXAZOLES AND THEIR REDUCTIVE CYCLIZATION TO AZEPINES

Abstract The Michel addition of styrylisoxazoles with ethyl benzoyl acetate in presence of ptoluene sulfonic acid (PTSA) catalyst supported on KSF solid furnished the Michael adducts in excellent yields in short time. The Michael adducts underwent reductive cyclization on treatment with SnCl 2 -MeOH to afford isoxazolo [4,5-b] azepines in high yields

An efficient one-pot three component synthesis of new isoxazolyl polyhydroacridine-1,8-diones in an ionic liquid medium

245-252A facile and convenient protocol has been developed for the fast and high yielding one-pot three component synthesis of isoxazolyl polyhydroacridine-1,8-diones from dimedone, aromatic aldehyde and isoxazolyl amine in the presence of ionic liquid [bmim]+BF4- as an efficient recyclable medium

Synthesis of new isoxazolyl coumarins by eco-friendly dipyridine cobalt chloride catalyzed Pechmann reaction at ambient temperature

532-535Dipyridine cobalt chloride is used as an alternative conven­tional Lewis acid catalyst in the Pechmann condensation of iso­xazolyl phenols with β-ketoesters leading to the formation of isoxazolyl coumarins. The method is simple, cost-effective and at ambient temperature gives good yields

A simplified Cadogan’s approach to synthesis of new isoxazolyl indazoles

1591-1596Isoxazolyl Schiff bases have been prepared from the corresponding amines by reaction with 2-nitrobenzaldehydes.These nitro compounds undergo de-oxygenative cyclization to give indazoles via nitrenes on heating with triethyl phosphite in acetonitrile. Isoxazolyl indazoles have also been synthesized in a one-pot reaction

Synthesis of novel isoxazolyl 1,3,5-benzoxadiazocine-4-thiones as possible biodynamic agents

1753-1758Synthesis of novel isoxazolyl 1,3,5-benzoxadiazocine-4-thiones 5 has been accomplished by condensation of 4-amino-3-methyl-5-styrylisoxazole 1 with salicylaldehydes, followed by reduction, treatment with arylisothiocyanates and subsequent ring closure in the presence of formaldehyde. The methodology used in this synthesis is the first approach of its kind towards the synthesis of title compounds

Synthesis of 1,3,5-triazinane-2-thiones and 1,3,5-oxadiazinane-4-thiones linked with isoxazoles

119-122 Trimolecular condensation of N-(3,5-dimethyl-4-isoxazolyl)-N'-arylthioureas 2 obtained from 1 by reaction with aryliso­thiocyanates, with aqueous formaldehyde and primary amines in toluene under reflux leads to 5-alkyl-1-(3,5-dimethyl-4-iso­xa­zolyl)-3-aryl-hexahydro-1,3,5-triazinane-2-thiones 3 in excellent yields. Condensation of 2 with aqueous formaldehyde under similar condition provides isoxazolyl 1,3,5-oxadiazinane-4-thiones 4. </smarttagtype

A fast, highly efficient and green protocol for Michael addition of active methylene compounds to styrylisoxazoles using task-specific basic ionic liquid [bmIm]OH as catalyst and green solvent

587-592A fast, highly efficient and green protocol for the Michael addition of active methylene compounds to styrylisoxazoles at room temperature has been investigated using task-specific basic ionic liquid, 3-butyl-1-methyl imidazolium hydroxide, [bmIm]OH, as a catalyst and green reaction medium. The reactions proceeded with excellent yields in short reaction times. The strategy is quite general and works with a variety of active methylene compounds. The ionic liquid can be recycled for subsequent reactions with consistent activity

ChemInform Abstract: A Fast, Highly Efficient and Green Protocol for Michael Addition of Active Methylene Compounds to Styrylisoxazoles Using Task-Specific Basic Ionic Liquid [bmIm]OH as Catalyst and Green Solvent.

587-592A fast, highly efficient and green protocol for the Michael addition of active methylene compounds to styrylisoxazoles at room temperature has been investigated using task-specific basic ionic liquid, 3-butyl-1-methyl imidazolium hydroxide, [bmIm]OH, as a catalyst and green reaction medium. The reactions proceeded with excellent yields in short reaction times. The strategy is quite general and works with a variety of active methylene compounds. The ionic liquid can be recycled for subsequent reactions with consistent activity

Synthesis and in vitro study of novel isoxazolyl benzoimidazolyl benzamides, acrylamides and propionamides as antimicrobial agents

1284-1290A series of novel 2/3 (1H-benzoimidazol-2-yl)-N-(5-methyl-3-isoxazolyl)-benzamides, acrylamides and propionamides have been synthesized and the antimicrobial activities are evaluated against two Gram-positive and two Gram-negative bacteria and two plant-pathogenic fungi. Some of the synthesized compounds have showed superior in vitro activities as compared to the standard drugs

Synthesis of thiazolyl benzimidazoles and thiazolyl coumarins linked to isoxazole as possible biodynamic agents

1658-1666A new series of linked heterocyclics, 5-(1H-benzo[d]imidazol-2-yl-methyl)-3-(3-methyl-5-[(E)-2-phenyl-1-ethenyl]-4-iso­xazol­yl)-2-aryl-1,3-thiazolan-4-ones 4 and 3-{3-methyl-5-[(E)-2-phenyl-1-ethenyl]-4-isoxazolyl}-5-(2-oxo-2H-3-chromenyl)-2-ar­yl-1,3-thiazolan-4-ones 5 have been synthesized by the cyclo­condensation of 4-benzalamino-3-methyl-5-styrylisoxazole 2 with mercapto succinic acid followed by cyclization with 1,2-phenylenediamines or salicylaldehydes. Structures of all the newly synthesized compounds 3-5 have been confirmed by spectral and micro analytical data