7 research outputs found
Comparison of the prognostic values of preoperative inflammation-based parameters in patients with breast cancer
<div><p>Peripheral blood-derived inflammation-based markers, including C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) are indicators of prognosis in various malignant tumors. The present study aimed to identify the inflammation-based parameters that are most suitable for predicting outcomes in patients with breast cancer. Two hundred ninety-six patients who underwent surgery for localized breast cancer were reviewed retrospectively. The association between clinicopathological factors and inflammation-based parameters were investigated. Univariate and multivariate Cox regression analyses were performed to identify independent prognostic indicators associated with disease-free survival (DFS). The NLR level correlated significantly with tumor size (P<0.05). The PLR level correlated with the expression of estrogen receptor and lymph node involvement (P<0.05). Univariate analysis revealed that lower CRP and PLR values as well as tumor size, lymph node involvement, and nuclear grade were significantly associated with superior DFS (CRP: P<0.01; PLR, tumor size, lymph node involvement, and nuclear grade: P<0.05). On multivariate analysis, CRP (hazard ratio [HR]: 2.85, 95% confidence interval [CI]: 1.03–7.88, P<0.05), PLR (HR: 2.61, 95% CI: 1.07–6.36, P<0.05) and nuclear grade (HR: 3.066, 95% CI: 1.26–7.49, P<0.05) were significant prognostic indicators of DFS in patients with breast cancer. Neither LMR nor NLR significantly predicted DFS. Both preoperative CRP and PLR values were independently associated with poor prognosis in patients with breast carcinoma; these were superior to other inflammation-based scores in terms of prognostic ability.</p></div
Basic characteristics of the enrolled patients.
<p>Basic characteristics of the enrolled patients.</p
Receiver operating characteristics analyses of inflammation-base parameters in patients with breast cancer.
<p>Receiver operating characteristics analyses of inflammation-base parameters in patients with breast cancer.</p
Kaplan-Meier analysis of disease-free survival stratified by inflammation-based parameters in patients with breast cancer.
<p>(A) C-reactive protein (CRP); (B) neutrophil-to-lymphocyte ratio (NLR); (C) lymphocyte-to-monocyte ratio (LMR); and (D) platelet-to-lympho cyte ratio (PLR).</p
Survival analyses of clinicopathological factors and inflammation-based scores.
<p>Survival analyses of clinicopathological factors and inflammation-based scores.</p
Association between inflammation-based parameters and clinicopathological factors in patients with breast cancer.
<p>Association between inflammation-based parameters and clinicopathological factors in patients with breast cancer.</p
Additional file 1: of A randomized phase II study to assess the effect of adjuvant immunotherapy using α-GalCer-pulsed dendritic cells in the patients with completely resected stage II–IIIA non-small cell lung cancer: study protocol for a randomized controlled trial
SPIRIT 2013 Checklist: recommended items to address in a clinical trial protocol and related documents*. (DOC 123 kb