Solutions to the Cocktail Party Problem in Insects: Selective Filters, Spatial Release from Masking and Gain Control in Tropical Crickets

Insects often communicate by sound in mixed species choruses; like humans and many vertebrates in crowded social environments they thus have to solve cocktail-party-like problems in order to ensure successful communication with conspecifics. This is even more a problem in species-rich environments like tropical rainforests, where background noise levels of up to 60 dB SPL have been measured.Using neurophysiological methods we investigated the effect of natural background noise (masker) on signal detection thresholds in two tropical cricket species Paroecanthus podagrosus and Diatrypa sp., both in the laboratory and outdoors. We identified three 'bottom-up' mechanisms which contribute to an excellent neuronal representation of conspecific signals despite the masking background. First, the sharply tuned frequency selectivity of the receiver reduces the amount of masking energy around the species-specific calling song frequency. Laboratory experiments yielded an average signal-to-noise ratio (SNR) of -8 dB, when masker and signal were broadcast from the same side. Secondly, displacing the masker by 180° from the signal improved SNRs by further 6 to 9 dB, a phenomenon known as spatial release from masking. Surprisingly, experiments carried out directly in the nocturnal rainforest yielded SNRs of about -23 dB compared with those in the laboratory with the same masker, where SNRs reached only -14.5 and -16 dB in both species. Finally, a neuronal gain control mechanism enhances the contrast between the responses to signals and the masker, by inhibition of neuronal activity in interstimulus intervals.Thus, conventional speaker playbacks in the lab apparently do not properly reconstruct the masking noise situation in a spatially realistic manner, since under real world conditions multiple sound sources are spatially distributed in space. Our results also indicate that without knowledge of the receiver properties and the spatial release mechanisms the detrimental effect of noise may be strongly overestimated

Nuklearna reakcija 164Dy(d, p) 165Dy

The 164Dy(d, p) 165Dy reaction was investigated with very high resolution. The spectra were recorded with two sets of measurements, with Ed = 14 MeV at the angle of 45◦ and Ed = 22 MeV at 35◦ . The intensity ratio of these measurements is a measure for the transfered angular momentum ∆l.Istraživana je nuklearna reakcija 164Dy(d, p) 165Dy s visokom rezolucijom. Preliminarni spektri dobiveni su za dva niza mjerenja, s Ed = 14 MeV pod kutom od 45◦ i s Ed = 22 MeV pod kutom od 35

The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFκB

AbstractWe describe functional binding sites for the tumor suppressor p53 and for NFκB residing in the promoter of the novel human early response gene p22/PRG1 (IEX-1/DIF-2). Gel shift and supershift assays demonstrate binding of p53 and NFκB to their corresponding sites in vitro. CAT-reporter gene assays show transactivation of the human p22/PRG1 promoter by p53 in Hep3B cells stably transfected with a temperature-sensitive mutant p53, but not in p53-deficient Hep3B cells. TNFα induced NFκB dependent transactivation was shown in HepG2 cells or in 818-4 pancreatic cancer cells. These data imply that human p22/PRG1 is a target gene for p53 and NFκB involved in growth regulation and stress response

Die Säkularisierung Europas 2002 bis 2016

Das Ausgangsniveau der Säkularisierung der Länder Europas nach 1989 spiegelt zwei Spannungslinien wider: den rezenten politischen Konflikt zwischen West und Ost und die historische konfessionelle Spaltung zwischen Katholizismus, Orthodoxie und Protestantismus. Wie stark bestimmen beide den Fortgang der Säkularisierung? Um diese Frage zu behandeln, werden zunächst die beiden Spannungslinien, die entsprechende Gruppierung der Länder und die Datenbasis zu ihrer Untersuchung vorgestellt. Anschließend werden Ausgangspunkt und Fortgang der Säkularisierung zwischen Ländergruppen verglichen

Structural Barriers In The Context Of Opiate Substitution Treatment In Germany - A Survey Among Physicians In Primary Care

Background Opiate substitution treatment (OST) is the most widely used treatment for opioid dependence in Germany with substantial long-term benefits for the patient and for society. Due to lessened restrictive admission criteria, the number of registered OST patients in Germany has increased continuously in the recent years, whereas the number of physicians providing OST has remained constant. Previous data already indicated a deteriorating situation in the availability or quality of OST delivered and that structural barriers impede physicians in actively providing OST. The present survey among a sample of primary care physicians in Germany aimed to identify and assess potential structural barriers for the provision of health care in the context of OST. Methods An anonymous written questionnaire was sent out to a sample of 2,332 physicians across Germany providing OST. Physicians contacted were identified through databases of the Federal State Chambers of Physicians and/or of the Federal Associations of Statutory Health Insurance Physicians. Data obtained were analysed descriptively. Results The response rate was 25,5% and the majority of 596 physicians sampled viewed substantial problems in terms of the regulatory framework of OST care in the German context. Furthermore, financial remuneration, insufficient qualification, as well as inadequate interdisciplinary cooperation in the treatment of comorbidities of opiate substituted patients were regarded as problematic. The number of physicians providing OST in Germany is expected to substantially decrease in the near future. Conclusion Despite less restrictive admission criteria for OST in Germany, the legal regulation framework for OST is still a limiting factor through raising concerns on the provider and consumer side to be unable to adhere to the strict rules. To avoid future shortages in the provision of OST care on the system level in Germany, revisions to the legal framework seem to be necessary. In regards to adequate care for drug use-related infectious diseases and psychiatric comorbidities commonly found in opiate substituted patients, efforts are required to improve professional qualifications of physicians providing OST as well as respective interdisciplinary collaboration