Elliptically polarizing undulator end designs

The magnetic end design of pure-permanent magnet Apple-II elliptically polarizing undulators (EPU) is discussed. Constraints on end block dimensions and positions are presented that guarantee steering and displacement free systems in both transverse directions and at all gaps for μ = 1 material. For block material with μ > 1 some beam steering (i.e. integrated dipole) may occur due to the ends; in particular, the integrated dipole strength varies with EPU phase. An optimization process is presented that assumes small perturbations about the μ = 1 solution and minimizes the variation in steering with EPU phase. We present numerical and experimental results that quantify the reduction in integrated dipole variation with phase. © 2006 IEEE

Error analysis for hybrid undulators

A general modeling framework is introduced that allows for the solution to magnetic field perturbations due to mechanical and magnetic tolerances in hybrid undulators. For example, both geometric pole errors and permanent magnet block geometry and strength errors can be considered. Of particular significance is the scaling of the various errors with variations in the gap of the device. In this work, the perturbation analysis is presented along with specific examples of errors found in hybrid undulators

Decellularized Matrix from Tumorigenic Human Mesenchymal Stem Cells Promotes Neovascularization with Galectin-1 Dependent Endothelial Interaction

BACKGROUND: Acquisition of a blood supply is fundamental for extensive tumor growth. We recently described vascular heterogeneity in tumours derived from cell clones of a human mesenchymal stem cell (hMSC) strain (hMSC-TERT20) immortalized by retroviral vector mediated human telomerase (hTERT) gene expression. Histological analysis showed that cells of the most vascularized tumorigenic clone, -BD11 had a pericyte-like alpha smooth muscle actin (ASMA+) and CD146+ positive phenotype. Upon serum withdrawal in culture, -BD11 cells formed cord-like structures mimicking capillary morphogenesis. In contrast, cells of the poorly tumorigenic clone, -BC8 did not stain for ASMA, tumours were less vascularized and serum withdrawal in culture led to cell death. By exploring the heterogeneity in hMSC-TERT20 clones we aimed to understand molecular mechanisms by which mesenchymal stem cells may promote neovascularization. METHODOLOGY/PRINCIPAL FINDINGS: Quantitative qRT-PCR analysis revealed similar mRNA levels for genes encoding the angiogenic cytokines VEGF and Angiopoietin-1 in both clones. However, clone-BD11 produced a denser extracellular matrix that supported stable ex vivo capillary morphogenesis of human endothelial cells and promoted in vivo neovascularization. Proteomic characterization of the -BD11 decellularized matrix identified 50 extracellular angiogenic proteins, including galectin-1. siRNA knock down of galectin-1 expression abrogated the ex vivo interaction between decellularized -BD11 matrix and endothelial cells. More stable shRNA knock down of galectin-1 expression did not prevent -BD11 tumorigenesis, but greatly reduced endothelial migration into -BD11 cell xenografts. CONCLUSIONS: Decellularized hMSC matrix had significant angiogenic potential with at least 50 angiogenic cell surface and extracellular proteins, implicated in attracting endothelial cells, their adhesion and activation to form tubular structures. hMSC -BD11 surface galectin-1 expression was required to bring about matrix-endothelial interactions and for xenografted hMSC -BD11 cells to optimally recruit host vasculature

Elliptically polarizing undulator end designs

The magnetic end design of pure-permanent magnet Apple-II elliptically polarizing undulators (EPU) is discussed. Constraints on end block dimensions and positions are presented that guarantee steering and displacement free systems in both transverse directions and at all gaps for μ = 1 material. For block material with μ > 1 some beam steering (i.e. integrated dipole) may occur due to the ends; in particular, the integrated dipole strength varies with EPU phase. An optimization process is presented that assumes small perturbations about the μ = 1 solution and minimizes the variation in steering with EPU phase. We present numerical and experimental results that quantify the reduction in integrated dipole variation with phase. © 2006 IEEE

Design of a cryogenic calorimeter for synchrotron light source Beam-Based heating

Superconducting insertion devices using Nb3Sn conductors offer the potential of higher brightness photon beams and enhanced spectral range over existing permanent magnet technology. However, Mb3Sn is a low temperature superconductor that must be operated at temperatures near 4.2 K. At these temperatures, any small heat dissipation can potentially be sufficient to lose the superconducting state of a section of a superconducting electromagnet. To quantify the amount of power deposited on the winding emanating from beam-induced heating on a storage ring, we propose a diagnostic calorimeter that will be temporarily integrated into the synchrotron ring. The design of the calorimeter is discussed and the various heat input sources, expected to disturb the operation of a superconducting electromagnet, are reviewed. © 2009 IEEE

Error analysis and field correction methods in superconducting undulators

In Free Electron Lasers (FEL), the electron trajectory through the undulator must meet stringent requirements in terms of trajectory wander and phase variation. This paper analyzes the feasibility of using line current pairs as correctors for superconducting undulators given a set of expected fabrication errors. A tolerance study has first been performed to investigate the impact of geometrical errors on the field quality. These errors are corrected with line currents that increase or decrease the magnetic field locally. Once the uncorrected trajectory is known, an algorithm finds the minimum number of correctors required to fulfill the trajectory specifications, and gives the corrector locations. All the correctors can be powered with the same current, greatly simplifying the implementation. The current then offers a degree of freedom to correct the trajectory and can be tuned dynamically as a function of the magnetic deflection

High-field studies of the slow thermal death of interlayer coherence in quasi-two-dimensional metals

The interlayer magnetoresistance sigma(zz) of the organic metal kappa-(BEDT-TTF)(2)Cu(NCS)(2) has been studied in fields B of up to 45 T and at temperatures T from 0.5 K to 50 K. The peak in rho(zz) seen in exactly in-plane fields, a definitive signature of interlayer coherence, remains to Ts exceeding the Anderson criterion for incoherent transport by a factor similar to 25. Angle-dependent magnetoresistance oscillations (AMROs) due to Fermi-surface orbits are suppressed by rising T, with a T-2 dependence suggesting electron-electron scattering

Development and analysis of HTS-undulator components for FEL applications

A high-performance superconducting undulator concept, incorporating stacked YBa2Cu3O7δ (YBCO) tapes operating at 4.2 K, is currently under investigation at LBNL as one of many technology options for future FEL applications. The concept is particularly promising for narrow-gap, short period (<10 mm) regimes, where traditional superconducting and permanent magnet technologies are less-suited. The current path is dictated by etching the YBCO layer using lithography techniques, resulting in a high degree of uniformity from tape to tape as well as a straightforward and highly cost-effective means of production. We describe the approaches being pursued for the tape preparation and the conceptual design of a device. We also provide an initial analysis of the impact of fabrication tolerances in terms of field errors for FEL application. © 2011 IEEE

Shimming correction of dynamic multipole effects on APPLE-II type epus at the ALS

Elliptically Polarizing Undulators [1] that provide full photon polarization control also have fast, intrinsic transverse roll-off of the magnetic field. The roll-off is especially fast for vertical polarization settings, and can have big detrimental effects on the nonlinear single particle dynamics. Particularly low and medium energy light sources and long period EPUs are prone to those effects. The three existing 50 mm period EPUs at the ALS have been retrofitted with shims to correct for these dynamic multipole effects and a new 90 mm period device which otherwise would have caused a huge reduction in dynamic aperture has been shimmed before installation. Beam dynamics measurements on all devices show that the shimming works very well and user operation with the long period EPU has begun