39 research outputs found
Myocardial stress imaging: a clinical tool has come of age
Coronary artery disease is a major cause of morbidity and mortality in the western
world (1 ). Depending on the progression and severity of coronary artery disease and the
myocardial response this may result in angina pectoris, myocardial infarction, chronic
ischemic heart disease and cardiac death. Several techniques have been developed to evaluate
patients with known or suspected coronary artery disease.
In 1973, Strauss and Zaret and coworkers (2,3) hypothesized that exercise should be
used to maximize differences in relative perfusion bet\veen normal and abnormal coronary
vascular beds during myocardial perfusion imaging. This is a safe and simple noninvasive
way of assessing myocardial perfusion at rest and to detect myocardial ischemia. In 1979,
Wann and colleagues (4) demonstrated that the mechanical consequences of ischemia can be
detected noninvasively by real-time two-dimensional stress echocardiography. Since then,
advances in exercise and pharmacological stress protocols, developments in nuclear
cardiology, and significant improvements in echocardiographic equipment have provided the
foundation for the growth of myocardial stress imaging (5-11 ).
Myocardial stress imaging has seen little to parallel its rapid development. Currently,
noninvasive imaging of the heart using radionuclide tracers under stress and resting
conditions and dobutamine stress echocardiography are established techniques for the
evaluation of patients with known or suspected coronary artery disease. Myocardial stress
imaging can b
Impact of Early Coronary Revascularization on Long-Term Outcomes in Patients With Myocardial Ischemia on Dobutamine Stress Echocardiography
The role of early coronary revascularization in the management of stable coronary artery disease remains controversial. The aim of this study was to evaluate the impact of early coronary revascularization on long-term outcomes (>10 years) after an ischemic dobutamine stress echocardiography (DSE) in patients with known or suspected coronary artery disease. Patients without stress-induced ischemia on DSE and those who underwent late coronary revascularization (>90 days after DSE) were excluded. The final study cohort consisted of 905 patients. A DSE with a peak wall motion score index of 1.1 to 1.7 was considered mild
Impact of sex on timing and clinical outcome of septal myectomy for obstructive hypertrophic cardiomyopathy
Background: Sex disparities are common in hypertrophic cardiomyopathy (HCM). Previous research has shown that at time of myectomy, women are older, have greater impairment of diastolic function and more advanced cardiac remodeling. The clinical impact of these differences is unknown. Method: This study included 162 HCM patients (61% m
Long-term prognostic value of dobutamine stress 99mTc-sestamibi SPECT: single-center experience with 8-year follow-up
PURPOSE: To determine the long-term prognostic value of dobutamine stress
technetium 99m (99mTc)-labeled sestamibi single photon emission computed
tomography (SPECT) in patients with limited exercise capacity. MATERIALS
AND METHODS: Clinical data and SPECT results were analyzed in 531
consecutive patients. Follow-up was successful in 528 (99.4%) patients; 55
underwent early revascularization and were excluded. Normal or abnormal
findings were considered in the absence or presence of fixed and/or
reversible perfusion defects. A summed stress score was calculated to
estimate the extent and severity of perfusion defects. Univariate and
multivariate Cox proportional hazards regression models were used to
identify independent predictors of late cardiac events. The incremental
value of myocardial perfusion scintigraphy over clinical variables in
predicting events was determined according to two models. The probability
of survival was calculated by using the Kaplan-Meier method. RESULTS:
Findings were abnormal in 312 patients. During 8.0 years +/- 1.5 of
follow-up (range, 4.5-10.6 years), cardiac death occurred in 67 patients
(total deaths, 165); nonfatal myocardial infarction, in 34; and late
revascularization, in 49. The annual rates for cardiac death, cardiac
death or infarction, and all events were 0.9%, 1.2%, and 1.5%,
respectively, after normal findings and 2.7%, 3.4%, and 4.4%,
respectively, after abnormal findings (P <.05). In a multivariable Cox
proportional hazards model, not only an abnormal finding but also the
summed stress score provided incremental prognostic information in
addition to clinical data. The hazard ratio for cardiac death was 1.09
(95% CI: 1.01, 1.18) per 1-unit increment of the summed stress score.
CONCLUSION: The incremental prognostic value of dobutamine stress
99mTc-sestamibi SPECT over clinical data was maintained over an 8-year
follow-up in patients with limited exercise capacity
Noninvasive evaluation of ischaemic heart disease: myocardial perfusion imaging or stress echocardiography?
Stress echocardiography and myocardial perfusion imaging are commonly used noninvasive imaging modalities for the evaluation of ischaemic heart disease. Both modalities have proved clinically useful in the entire spectrum of coronary artery disease. Both techniques can detect coronary artery disease and provide prognostic information. Both techniques can identify low-risk and high-risk subsets among patients with known or suspected coronary artery disease and thus guide patient management decisions. In patients with acute myocardial infarction, both techniques have been used to identify residual viable tissue and predict improvement of function over time. In patients with chronic ischaemic left ventricular (LV) dysfunction, viability assessment with either modality can be used to predict improvement of function after revascularisation and thus guide patient treatment
Prognostic significance of anterior mitral valve leaflet length in individuals with a hypertrophic cardiomyopathy gene mutation without hypertrophic changes
Purpose: Previous studies suggest that anterior mitral valve leaflet (AMVL) elongation is a primary phenotypic feature in hypertrophic cardiomyopathy (HCM). Our aim was to assess AMVL length in individuals with HCM gene mutations and in healthy controls and to identify predictors of the development of HCM during follow-up. Methods: