Assessment of Toxicity of Some Penta- and Hexacoordinated Organotin(IV) and Tetracoordinated Tin(II) Complexes of Heterocyclic β-Diketones

A number of penta- and hexacoordinated organotin(IV) complexes and tetracoordinated tin(II) complexes of compositions [Formula: see text] (where R = − CH(3), −p−ClC(6)H(4), and −C(6)H(5)), [Formula: see text] (where R = −CH(3), and −C(6)H(5)), and Sn(II) [Formula: see text] (where R = −p−ClC(6)H(4) and −C(6)H(5)) were screened for their toxicity against Musca domestica (house fly). In general, organotin(IV) complexes contribute more to the activity than tin(II) complexes

Depression, cognitive impairment and physical functional outcome and their associated factors in stroke patients in community hospital care

Master'sMASTER OF SCIENCE (CLINICAL SCIENCE

Toxicity of Certain Penta-Coordinated Organotin(IV) and Tetra-Coordinated Tin(II) Complexes of Heterocyclic β-Diketones Against the Larvae of Aedes Aegypti (Liston)

Some organotin(IV) and tin(II) complexes of composition R3Sn[R'COC:CON(C6H5)N:CCH3] (where R=C4H9, R'=CH3, C3H5, p-ClC6H4; R=C6H5, R'=C6H5 and p-ClC6H4) and Sn[p-ClC6H4COC:CON(C6H5)N:CCH3]2 were screened for their toxicity against Aedes aegypti larvae. Organotin(IV) complexes were more active than tin(II) complexes

Organic-inorganic hybrid complexes of Lead(II) of sterically demanding heterocyclic β-diketones and flexible N-protected amino acids

202-208A new set of organic-inorganic hybrid complexes of lead(II) of sterically demanding heterocyclic β-diketones and flexible N-protected amino acids of composition Pb[RC(O)CH3][CHR'COO] (where R = C6H5, p-ClC6H4, CH3 and R’ = CH(CH3)C2H5, CH2CH(CH3)2 and CH(CH3)2 ) has been generated by the reactions of freshly prepared lead isopropoxide with sterically demanding heterocyclic β-diketones (LH) and flexible N-protected amino acids (AH) in 1:1:1 molar ratio in refluxing dry benzene . These lead(II) complexes of mixed organic ligands have been characterized on the basis of physico-chemical and spectroscopic studies

Increased incidence of glomerulonephritis following spleno-renal shunt surgery in non-cirrhotic portal fibrosis

Increased incidence of glomerulonephritis following spleno-renal shunt surgery in non-cirrhotic portal fibrosis. In a prospective study of 200 non-cirrhotic portal fibrosis (NCPF) patients, 7% had mild proteinuria and their renal biopsies showed mild mesangial proliferative glomerulonephritis (mes-PGN). The remaining 93% biopsies were normal. However, following the insertion of a spleno-renal shunt (SRS) for portal hypertension 32% of these patients developed nephrotic syndrome in five years. Renal histology revealed mesangiocapillary glomerulonephritis (MCGN) (18.5%), mes-PGN (9%), minimal change nephropathy (3%), and chronic sclerosing GN (1.5%). Immunofluorescence showed granular deposition of IgA and C3. IgA2 was the predominant form of Ig in the glomerular deposits, indicating that IgA in the immune complexes was derived from the gastrointestinal tract. Electron microscopy revealed electron dense deposits in the mesangium. In contrast to the NCPF patients who underwent a SRS for portal hypertension, the 200 patients in our study who underwent spleno-renal shunting because of extra hepatic portal obstruction did not have renal disease, nor did they develop renal disease during the five-year post-operative follow-up. Fifty percent of the glomerulonephritis (GN) in the NCPF group progressed to renal failure in five years; 46.6% continued to have proteinuria. Low serum complement, C3 (40%) and circulating immune complexes (14.8%) were detected in the glomerulonephritis group. Our study shows that: (i) there is a high rate of the occurrence of GN following SRS in NCPF patients, but not in those with normal livers; (ii) the type of GN is primarily IgA nephropathy; and (iii) the GN could be the result of defective hepatic reticuloendothelial function in the NCPF group that is worsened by the shunting procedure

Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016

Synthesis and characterization of mixed ligand complexes of cobalt(II) and nickel( II) containing trans-[14]-diene and organic monobasic acids Synthesis and spectral studies of some aluminium(lll) complexes of N-protected amino acids

620-622A series of aluminium complexes of general formula AlCl3-n[OOCCH(R)(O)]n (where R= -CH3, -CH2C6H5 and n= 1,2,3) has been isolated by the interaction of aluminium trichloride with N-protected amino acids in 1:1, 1:2 and 1:3 molar ratios in dry diethyl ether solution. The tentative structures of these complexes have been suggested on the basis of elemental analyses, mol. wt. measurement and spectral studies. The freshly prepared complexes are monomers. 27Al NMR reveals the presence of four-, five- and six-coordinate aluminium centres in the complexes, [AlCI2(L)], [AlCl(L)2] and [Al(L)3], respectively

Aetiopathogenesis of Type -2 Diabetes Mellitus: Could Chronic Stress Play an Important Role?

Abstract Objectives : Pathogenesis of type-2 diabetes remains elusive. Various factors including diet, physical exercise, obesity, genetic factors and stress, have been discussed. Among these factors role of stress is still poorly understood in diabetes. Therefore the study was planned to assess effect of stress in diabetic and non-diabetic population in a comparative descriptive manner. Methods : 1000 diabetic cases (group A) and equal number of healthy individuals were selected as a comparison group (group B). Both groups were examined at 0, 12, 24 months. To assess stress 17 points were examined (factors mainly related to emotions, hurriedness, relaxed status etc.), total 68 points for stress were given; > 30/68 was considered as severe stress. Mental health life style factors like duration of sleep and working mental hours were also examined. EEG and SSR were done at 24 months to assess stress and sympathetic response. Results : There was presence of chronic stress, (> 90% had > 30/68 scoring) more mental work and less sleep duration in group A. EEG showed synchronised v/s desynchronised basal rhythm in group B v/s group A. SSR suggestive of increased sympathetic activity in group A. Conclusion : It is concluded that chronic stress leads to increased basal sympathetic activity, resulting from disturbed cortical hypothalamic axis, leading to central insulin resistance and diabetes

Synthesis & Characterisation of Some Non-bridged & Bridged η1:η5 -Dicyclopentadienyl Zirconium Pyrazolone Complexes

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