1 research outputs found
Efek Hepatoprotektor Ekstrak Daun Dandang Gendis (Clinacanthus nutans) terhadap Kadar SGPT Tikus Putih (Rattus novergicus) yang Diinduksi Parasetamol
Background: Paracetamol was a safe drug, but would cause oxidative stress if
taken too much.. Dandang gendis leaves contained a flavonoid antioxidant. This
research intended to prove the antioxidant effect of dandang gendis leaves that
could prevent liver cell damage of white rat induced by paracetamol.
Methods: This research was an experimental laboratoric with post test only control
group design. This research had taken place at Parasitology and Micology Faculty of
Medicine Sebelas Maret University Surakarta. The sample was 32 Wistar white rats.
The dependent variable was the SGPT level of white rats and the independent
variable was the dandang gendis leaves extract. The white rats were divided into 4
groups: negative control group (KK0), positive control group (KK1), first threated
group (KP1), and second threated group (KP2). KP1 had been given 30 mg/200 gr
BB dose and KP2 had been given 60 mg/200 gr BB dose for 14 days. At 11
th
β 13
th
days, the white rats from KK1, KP1, and KP2 had been given 291.6 mg/200 gr BB
dose of paracetamol. At 14
th
day, ratβs blood had been taken from orbitalis sinus.
The damage of the liver cell had been measured with SGPT laboratory test. The data
had been analyzed with one way ANOVA test then with post hoc test (Ξ± = 0.05).
Results: The highest rate of SGPT levels was KK1, following KP1, KP2, and the
lowest was KK0. Oneway ANOVA test resuls showed a significant difference among
the four groups with p = 0.000. Post hoc test results showed a significant difference
between KK0 β KK1 (p = 0.003) and KK0 β KP2 (p = 0.019) whereas between KK0 β
KP1 (p = 0.204), KK1 β KP1 (p = 0.885), KK1 β KP2 (p = 0.077), and KP1 β KP2 (p
= 0.932) had no significant difference.
Conclusion: Giving dandang gendis leaves extract was not significant to raise the
SGPT level of white rat induced by paracetamol. Raising dandang gendis leaves
extract doses was not significant to raise its hepatoprotector effec