1 research outputs found
Fungal bis-Naphthopyrones as Inhibitors of Botulinum Neurotoxin Serotype A
An in silico screen of the NIH Molecular Library Small
Molecule
Repository (MLSMR) of ∼350000 compounds and confirmatory bioassays
led to identification of chaetochromin A (<b>1</b>) as an inhibitor
of botulinum neurotoxin serotype A (BoNT A). Subsequent acquisition
and testing of analogues of <b>1</b> uncovered two compounds,
talaroderxines A (<b>2</b>) and B (<b>3</b>), with improved
activity. These are the first fungal metabolites reported to exhibit
BoNT/A inhibitory activity