Glucose, BMI and pre-neoplastic lesions in the cervix [Glucosa, índice de masa corporal y lesiones preneoplásicas en el cuello uterino]

Background: The obesity and abnormal blood glucose level has been associated with cervical cancer development; however, few studies have been performed about this relation. Objective: Evaluate the blood glucose levels and body mass index (BMI) in women with human papilloma virus infection (HPV-I) and cervical intraepithelial neoplasia (CIN-I). Patients and method: Transversal study of 44 women diagnosed with HPV-I and CIN-I from September to December 2010 in Dysplasia Clinic of Regional Hospital of Guzman City, Federal entity of Jalisco, Mexico. The diagnoses were carried by biopsy of cervix, glucose test results were evaluated by spectrophotometry and determinate the BMI. Results: The 18% (n=8) of women were without injury, 41% (n=18), with HPV-I and 41% (n=18) CIN-I. High blood glucose was observed in CIN-I versus without injury in the cervix (p = 0.05), the correlation was OR = 2.6 (95% CI: 1.090-6.52). The young women (19-35 years) were 17% high glucose, 28% normal glucose and 55% low glucose. In group of the medium age (35-65 years) 23% showed high glucose, 50% normal and 27% low. The BMI was not relation with diagnosis, although in the age (young versus age median p=0.001). Conclusion: These results support the proposal about the high levels of glucose in plasma and obesity could be risk cofactors in the development of preneoplasic lesion of cervix

Glucose, BMI and pre-neoplastic lesions in the cervix [Glucosa, índice de masa corporal y lesiones preneoplásicas en el cuello uterino]

Background: The obesity and abnormal blood glucose level has been associated with cervical cancer development; however, few studies have been performed about this relation. Objective: Evaluate the blood glucose levels and body mass index (BMI) in women with human papilloma virus infection (HPV-I) and cervical intraepithelial neoplasia (CIN-I). Patients and method: Transversal study of 44 women diagnosed with HPV-I and CIN-I from September to December 2010 in Dysplasia Clinic of Regional Hospital of Guzman City, Federal entity of Jalisco, Mexico. The diagnoses were carried by biopsy of cervix, glucose test results were evaluated by spectrophotometry and determinate the BMI. Results: The 18% (n=8) of women were without injury, 41% (n=18), with HPV-I and 41% (n=18) CIN-I. High blood glucose was observed in CIN-I versus without injury in the cervix (p = 0.05), the correlation was OR = 2.6 (95% CI: 1.090-6.52). The young women (19-35 years) were 17% high glucose, 28% normal glucose and 55% low glucose. In group of the medium age (35-65 years) 23% showed high glucose, 50% normal and 27% low. The BMI was not relation with diagnosis, although in the age (young versus age median p=0.001). Conclusion: These results support the proposal about the high levels of glucose in plasma and obesity could be risk cofactors in the development of preneoplasic lesion of cervix

France and the United Kingdom: demographic stability on the continent, stop-and-go across the Channel

International audienceIn the mid-eighteenth century, the population of France was four times larger than that of the United Kingdom (around 25 million versus 6 million). In the late eighteenth and nineteenth century, population growth was much weaker in France than in the UK, and by 1918 the two populations were the same size (nearly 40 million inhabitants). The UK population then continued to grow, so that by 1944 it was larger than France’s by 10 million (49 million versus 39 million). After World War II, France’s population gradually recovered, and since the mid-1990s, the two populations have remained fairly similar in size and increased at the same pace. However, recent population growth has been more regular in France and is due primarily to natural increase (births minus deaths), whereas in the UK net migration (the difference between migrant entries and departures) is the main growth factor

Levels of oxidative stress in serum and dietary behavior in adults in a rural area of Jalisco, Mexico [Indicadores de estr�s oxidativo en suero y comportamiento alimentario en adultos de una zona rural de Jalisco, M�xico]

Introduction: The feeding behavior establishes a relation of humans with food, includes food habits that could be involved with oxidative stress. Objective: To evaluate the relation of indicators of oxidative stress (lipid peroxides) and antioxidant (ascorbic acid, catalase, superoxide dismutase) with feeding behavior in adults of Teocuhitatlan Corona, Jalisco, Mexico. Method: Study observational, descriptive, cross-sectional of 44 adults with 43 to 88 years, was used a instrument of feeding behavior. The questionnaire were related to indicators of oxidative stress. Were used descriptive statistics, frequency distribution and analysis of covariance with adjustment variables, was considered significant p <0.05. Results: The values of serum lipid peroxides were related to behaviors: consider the nutritional content as most important when choosing food (p = 0.042), dislike milk (p = 0.027), intake of sweets between meals (p = 0.001), habitual inclusion of vegetables and salads in main meal (p = 0.018). We do not found association in to values of ascorbic acid, cholesterol in low density lipoproteins and enzymatic activities of catalase and superoxide dismutase with food behaviors. Discussion: The feeding behaviors analyzed in this study may be involved with development of oxidative stress and could be have protective or harmful effect in development to complications of chronic non-com-municable diseases and aging in this population. This suggests to analyze demographic and socio-cultural aspects of region and besides analyzing the consumption and metabolic markers related to food. � 2015, Grupo Aula Medica S.A. All rights reserved

CD28-, CD45RAnull/dim and natural killer-like CD8+ T cells are increased in peripheral blood of women with low-grade cervical lesions

Background: In response to antigen naive CD8+, T cells differentiate into effector cells, which express Natural killer (NK) receptors, lose CD28 expression, and die by apoptosis. However, in smaller quantities, the cells are retained for subsequent exposure to the same antigen. Knowledge is limited regarding whether the percentages of CD28-, Effector memory (EMRAnull/dim), and the CD16+/CD56 + CD8+ T cells of women with low-grade cervical lesions are altered at a systemic level.Methods: We enrolled in this study women controls and women with Human papilloma virus infection (HPV-I) without associated cellular neoplastic changes and with Cervical Intraepithelial Neoplastic-I (CIN-I). Flow cytometry (FC) was performed for measurement of CD28-, memory subset, and NK-like CD8 + T cells, and IL-17, IFN-gamma, Tumor necrosis factor (TNF)-alpha, Interleukin (IL)-10, IL-6, IL-4, and IL-2. Finally, we genotyped the HPV.Results: The CIN-I group increased the CD8 + CD28- and CD16+/56+ T cell percentage compared with that of HPV-I and controls (p &lt;0.01), and CD8 + CCR7-CD45RAnull/dim (EMRAnull/dim) T cells were also increased in the CIN-I group compared with the controls (p &lt;0.01). These two study groups were HPV- genotyped; 49% were HPV18+, and we did not observe differences in cytokine levels among all groups.Conclusions: Increased levels of CD28-, EMRAnull/dim, and CD16+/CD56 + CD8+ T cells of peripheral blood in women with CIN-I may be associated with persistent HPV infection and could exert an influence on progression to cervical cancer. Zapotitlán 2014 Pita-Lopez et al.; licensee BioMed Central Ltd.Central Ltd

MDR1 C3435T polymorphism in Mexican patients with breast cancer

We investigated whether the MDR1 C3435T polymorphism is associated with fibrocystic changes (FCC), infiltrating ductal breast cancer (IDBC), and/or clinical-pathological features of IDBC in Mexican patients. Samples from women who received surgical treatment in 2007 at the Centro M�dico de Occidente (M�xico) were included in the analysis. Genotyping was performed by polymerase chain reaction-restricted fragment length polymorphisms in 64 paraffin-embedded breast samples with IDBC, 64 samples with FCC, and 183 peripheral blood samples of healthy females designated as the healthy group (HG). The frequency of the T allele was 41, 45, and 52% for the FCC, IDBC, and HG samples, respectively. Significant differences were only found between the FCC and HG samples [odds ratio (OR) = 0.64, 95% confidence interval (CI) = 0.43-0.96; P = 0.032]. The prevalence of the T/T genotype was 8, 13, and 24% for FCC, IDBC, and HG samples, respectively. Again, statistical differences were only found between FCC and HG samples for the T/T genotype (OR = 0.28, 95%CI = 0.106-0.77; P = 0.009). Although the T allele and the T/T genotype were less frequent in the IDBC group than in the HG, the differences were not significant. Furthermore, no associations were found between the C3435T polymorphism and clinical-pathological features of the IDBC group. Both the FCC and IDBC groups had a high frequency of the C allele relative to the HG in this sample of women from Western Mexico. � FUNPEC-RP