Differential gene expression in cells from Fabry and Gaucher diseases: cell reprogramming and culture aging

Gene expression varies deeply, even in the same individual’s cells, depending on stress factors, cell aging, gene variants or gene and cell manipulation In this work, gene expression can be seen to shift in many genes, using fibroblasts from donors with Fabry and Gaucher type 3 genetic diseases Tests were also made to compare the impact of aging cultures Real time qRT PCR protocols for genes of interest were used for expression comparison after cell induction and reprogramming.FCT project PTDC/BIM-MEC/4762/2014 (CeMoLy)info:eu-repo/semantics/publishedVersio

Region's reputation and the price of regional products: a hedonic analysis of Portuguese quality cheese

Resources (tangible and intangible) can be mobilized to increase region's reputation and image giving a competitive advantage to certain products with origin in that region. The returns of a region's resources depend upon the ability of local firms to appropriate the rents earned and whether the consumers value the characteristics of the region that are associated with the product, being disposed to pay a price premium. The estimation of a hedonic price function, which relates the price of Portuguese regional cheeses to its various attributes provided empirical support to test the importance of designation of origin on price. The study showsthat some designations of origin and milk types have a significant impact on price, while retailer format (hypermarket versus online store)and cheese characteristics (cured versus not cured)are nor significant. Specifically, while cheeses from regions of Minho e Trás os Montes and Alentejo are expected to have price premiums, cheeses from regions of Beiras and Ilhas are expected to have discounts. Also, cheeses made with mixed milk and goat's and ewe's milk all have positive effects on price regarding cow's milk (base category).

Regional Products, Regions' Reputation and Commercial Strategies: A Tale of Two Cheese Suppliers

Networks of firms producing and selling regional products to domestic and foreign markets are influencing the direction and options of local development. Regional products are embedded in historical tradition and geographic, cultural and social specificity. Most of the local activities are performed by clustered SME's in well defined geographical areas. To study the mechanisms and factors which favour spontaneous development in specific areas and make SME's competitive through cluster development we used case study methodology. An evolutionary perspective of "Casa Matias" and "Casa dos Queijos", two portuguese SME's, is expected to illustrate which key factors triggered the firm's cheese business and, simultaneously, examine organisational practices with particular emphasis on cluster formation and internationalisation process. From this analysis we expected to conceptualise a specific policy scheme to help developing spontaneous entrepreneurship, cooperation between clustered SME's and local collective development.

Product Attribute Saliency and Region of Origin: Some Empirical Evidence from Portugal

This paper empirically investigates the extent to which consumer preferences may act as promoters of regional products. Three products are studied in terms of the importance consumers attach to various product attributes with particular emphasis on region of origin information. The estimation of a hedonic price function, which relates the price of Portuguese regional products to its various attributes, provided empirical support to the hypothesis that region of origin matters to consumers. The study shows that wine, olive oil and cheese from some regions of origin have a significant impact on price. Particularly, some regions of origin are expected to have price premiums, while others are expected to have discounts.regional products, hedonic approach, wine, olive oil, cheese, Food Consumption/Nutrition/Food Safety, C21, D83, Q18,