Mean [¹¹C]FLB 457 BP changes in prefrontal regions following left and right DLPFC.

<p>ACC: anterior cingulated cortex, OFC: orbitofrontal cortex, DLPFC: dorsolateral prefrontal cortex, Number in brackets indicates S.D.</p><p>*Bonferroni correction.</p

Individual mean BPs extracted from 10 mm radius VOI.

<p>Upper, middle and lower figures show the individual [¹¹C]FLB 457 BP changes the subgenual ACC (x = −10, y = 28, z = −18), pregenual ACC (x = −14, y = 40, z = −10) and medial orbitofrontal cortex (x = −6, y = 30, z = −20) under control and active rTMS conditions, respectively.</p

Prefrontal regions with reduction in [¹¹C]FLB 457 BP following left DLPFC stimulation.

<p>L: left, ACC: anterior cingulated cortex, OFC: orbitofrontal cortex, BA: Brodmann's area *Talairach coordinate (mm), SVC: small volume correction.</p

Timeline of the experimental setup for rTMS and [¹¹C]FLB 457 PET imaging.

<p>Timeline of the experimental setup for rTMS and [¹¹C]FLB 457 PET imaging.</p

Contrast analysis for each stimulation conditions: changes in [11C]FLB 457 BP of the stimulated hemisphere were tested against [11C]FLB 457 BP of the ipsilateral (non-stimulated) hemisphere of the other session (control).

<p>Red mark indicate stimulation site.</p

Sagittal and transverse sections of the statistical parametric map of the changes in [¹¹C]FLB 457 BP after left DLPFC stimulation overlaid upon the standard MRI.

<p>Sagittal and transverse sections of the statistical parametric map of the changes in [¹¹C]FLB 457 BP after left DLPFC stimulation overlaid upon the standard MRI.</p