Book review: le gouvernement des catastrophes

Le gouvernement des catastrophes, Sandrine Revet, Julien Langumier (Eds), Karthala, 2013, 286 p

compte rendu d'ouvrage: Persyn-Vialard, Sandrine, La linguistique de Karl Bühler, Examen critique de la Sprachtheorie et de sa filiation

Histoire Epistémologie Langage, 30, 1, 163-165compte rendu de: Persyn-Vialard, Sandrine, La linguistique de Karl Bühler, Examen critique de la Sprachtheorie et de sa filiation, Presses Universitaires de Rennes, 2005, 280 p., ISBN 2-7535- 0149-1

Determination of an optimal response cut-off able to predict progression-free survival in patients with well-differentiated advanced pancreatic neuroendocrine tumours treated with sunitinib: an alternative to the current RECIST-defined response.

BACKGROUND: Sunitinib prolongs progression-free survival (PFS) in patients with advanced pancreatic neuroendocrine tumours (pNET). Response Evaluation Criteria in Solid Tumors (RECIST)-defined partial responses (PR; classically defined as ⩾30% size decrease from baseline) are infrequent. METHODS: Individual data of pNET patients from the phase II [NCT00056693] and pivotal phase III [NCT00428597] trials of sunitinib were analysed in this investigator-initiated, post hoc study. The primary objective was to determine the optimal RECIST (v.1.0) response cut-off value to identify patients who were progression-free at 11 months (median PFS in phase III trial); and the most informative time-point (highest area under the curve (AUC) by receiver operating characteristic (ROC) analysis and logistic regression) for prediction of benefit (PFS) from sunitinib. RESULTS: Data for 237 patients (85 placebo; 152 sunitinib (n=66.50 mg \u274-weeks on/2-weeks off\u27 schedule; n=86 \u2737.5 mg continuous daily dosing (CDD)\u27)) and 788 scans were analysed. The median PFS for sunitinib and placebo were 9.3 months (95% CI 7.6-12.2) and 5.4 months (95% CI 3.5-6.01), respectively (hazard ratio (HR) 0.43 (95% CI 0.29-0.62); P CONCLUSIONS: A 10% reduction within marker lesions identifies pNET patients benefiting from sunitinib treatment with implications for maintenance of dose intensity and future trial design

Texts Less Travelled: The Case of Women Philosophers

This chapter discusses several possible reasons why works by women philosophers have traveled significantly less than those written by men, although women’s contributions go back to the start of European history of philosophy. Differentiating between geographic, linguistic, historic and philosophical travels, Tove Pettersen claims that gender is particularly significant with regard to historical and philosophical traveling. As the case of women philosophers clearly demonstrate, gender hampers the circulation of certain texts and inhibit transhistorical exchange of knowledge and ideas. ****** Che chapitre examine plusieurs raisons possibles pour expliquer pourquoi les œuvres de femmes philosophes ont “voyage” beaucoup moins que celle des hommes, bien que la contribution des femmes remonte au début de l´histoire européenne de la philosophie. Distinguant entre plusieurs façons de voyager – géographique, linguistique, historique et philosophique –, Tove Pettersen soutient que le “genre” est un facteur particulièrement significative par rapport au voyage historique et philosophique- Comme le démontre clairement le cas des femmes philosophes, leur genre nuit á la circulation de certains textes ainsi qu’à l’échange transnational du savoir et des idées