Seroprevalencia de anticuerpos para SARS-COV2, cuantificado por el método de Quimioluminiscencia en pacientes atendidos en la Clínica Ssosma de Nuevo Chimbote, 2021

La presente investigación pretende determinar la seroprevalencia de anticuerpos SARS- CoV- 2; además este método de Quimioluminiscencia actualmente posee una sensibilidad del 98.11% y una especificidad del 99.22% lo que la convierte en una prueba eficaz, sin embargo, cabe recalcar que este método de quimioluminiscencia es una ayuda al diagnóstico del SARS-CoV-2, que de la misma forma tiene su tiempo de uso que es entre el séptimo día después de haber iniciado los síntomas. Por lo tanto, planteamos el objetivo de \"Determinar la seroprevalencia de anticuerpos SARS-CoV-2, cuantificado por el método de quimioluminiscencia en pacientes atendidos en la Clínica Ssosma de nuevo Chimbote, 2021\". La población estará constituida por todos los pacientes atendidos en la clínica Ssosma durante el 2021. Esta investigación es de tipo descriptivo, cuantitativo, transversal y retrospectivo. La técnica es documental porque se recolectarán los datos de la oficina de estadística. Se incluirán a los pacientes que tenga como resultado reactivo a anticuerpo IgM, IgG y IgM- IgG. Se utilizará como instrumento una ficha de recolección de datos. En conclusión la seroprevalencia de anticuerpos SARS-CoV-2 en los pacientes atendidos en la clínica SSOSMA fue del 87.6%.Tesi

Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries

Background Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)