Translated <i>C. victoriae</i> conantokin (A), con-ikot-ikot (B), conodipine (C) and B2-superfamily (D) precursor sequences.

<p>*, Con-Gm <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Abogadie1" target="_blank">[51]</a>, G56 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Hu1" target="_blank">[5]</a>, con-ikot-ikot <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Walker2" target="_blank">[52]</a>, p21a <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Mller1" target="_blank">[53]</a>, Conodipine-M <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-McIntosh1" target="_blank">[54]</a> and B2-superfamily sequences from <i>C. literratus </i><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Pi1" target="_blank">[57]</a> and <i>C. consors </i><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Violette1" target="_blank">[56]</a> are shown for comparison. The conodipine catalytic His-Asp dyad is boxed in red.</p

Translated <i>C. victoriae</i> O2-superfamily (A) and contryphan (B) precursor sequences.

<p>*, TxVIIA <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Conticello1" target="_blank">[78]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Nakamura1" target="_blank">[81]</a> and contryphan-R/Tx precursors <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Jimenez2" target="_blank">[82]</a> shown for comparison.</p

Translated <i>C. victoriae</i> I1-superfamily (A), I2-superfamily (B) and I4-superfamily (C) precursor sequences.

<p>*, M11.2 mature peptide <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Buczek2" target="_blank">[24]</a>, Ep11.1 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Buczek3" target="_blank">[25]</a> precursor, ViTx precursor <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Kauferstein1" target="_blank">[26]</a>, Gla-TxX precursor <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Brown1" target="_blank">[77]</a>and the I3-superfamily (D) precursor Ca11a <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Yuan1" target="_blank">[60]</a>shown for comparison.</p

Functional diversity encoded in the venom gland transcriptome of <i>C. victoriae</i>.

<p>Each conotoxin superfamily is divided into groups according to cysteine framework, with the number identified in <i>C. victoriae</i> and a summary of biological activity associated with each group indicated.</p><p>AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; GABA, γ-aminobutyric acid; GPCR, G protein-coupled receptor; IC, intracranial injection; nAChR, nicotinic acetylcholine receptor; N.D., not determined; NMDA, N-Methyl-D-aspartate; sst, somatostatin.</p

Translated <i>C. victoriae</i> O1-superfamily precursor sequences.

<p>*, Vc6.1, Vc6.3, Vc6.4, Vc6.6 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Jakubowski1" target="_blank">[11]</a> and MrVIB <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-McIntosh2" target="_blank">[80]</a> shown for comparison.</p

Translated <i>C. victoriae</i> E-superfamily (A), F-superfamily (B), H-superfamily (C) and U-superfamily (D) precursor sequences.

<p>*, Mr104 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Dutertre1" target="_blank">[34]</a>, Mr105 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Dutertre1" target="_blank">[34]</a>, other H-superfamily precursors (Mr097, Mr098, Mr099 and Mr100) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Dutertre1" target="_blank">[34]</a>and the textile convulsant peptide <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Cruz1" target="_blank">[63]</a> are shown for comparison.</p

Translated <i>C. victoriae</i> O3-superfamily (A), P-superfamily (B) and S-superfamily (C) precursor sequences.

<p>*, Bromosleeper peptide (GenBank: GQ981406.1) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Craig1" target="_blank">[41]</a>, Gm9.1 (GmIXA) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Miles1" target="_blank">[43]</a>, Tx8.1 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Liu1" target="_blank">[46]</a>, GVIIIA <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-England1" target="_blank">[44]</a> and RVIIIA <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Teichert1" target="_blank">[45]</a> precursors shown for comparison.</p

Translated <i>C. victoriae</i> J-superfamily (A), M-superfamily (B), M-conomarphin (C) precursor sequences.

<p>*, pl14a <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Imperial1" target="_blank">[29]</a>, Tx3.2 (tx3a) <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Corpuz1" target="_blank">[32]</a>, TxMMSK-05 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Conticello1" target="_blank">[78]</a>, LtIIIA <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Wang1" target="_blank">[33]</a>, conomarphin <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Han1" target="_blank">[79]</a>, Mr038 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087648#pone.0087648-Dutertre1" target="_blank">[34]</a> precursors shown for comparison.</p

<i>C. victoriae</i> Hhe53-like open reading frame displaying translation of forward frames 1 and 2.

<p>Possible initiator codon in frame 2 is underlined in purple and the sequence encoding the predicted mature peptide in frame 1 is underlined in black.</p

Relative abundance of conotoxin superfamilies (total reads assembled for conotoxin precursors of each superfamily).

<p>High abundance reads may be under-represented as a result of cDNA library normalization.</p