3 research outputs found
Tubular Adenoma of the Breast: A Rare Presentation and Review of the Literature
Tubular adenomas, also known as pure adenomas, are rare epithelial tumors of the breast. Only a few cases have been reported in the literature, especially in young women of reproductive age. Postmenopausal women are very rarely affected. We describe here a very rare case of tubular breast adenoma in a postmenopausal woman who presented with a gradually enlarging breast lump. Clinical examination and imaging studies revealed a non-tender well circumscribed left breast tumor suggestive of a fibroadenoma. Due to the history of progressive enlargement of the breast lump, a surgical excision was performed. Histological findings were suggestive of a tubular breast adenoma. We conclude that although tubular breast adenoma is rare, it should always be considered in the differential diagnosis in postmenopausal patients presenting with a gradually enlarging breast mass. Preoperative diagnosis is difficult because tubular adenoma is indistinguishable from a fibroadenoma on physical examination and breast imaging. Surgical excision is necessary to establish a definitive diagnosis. Clinical presentation and management of our patient are discussed along with a review of the literature
Whipple Disease
Whipple disease (WD) is a rare disease caused by Tropheryma whipplei.
The classic profile of the patient is that of a middle-aged man
presenting with fever, chronic diarrhea, and arthralgias.
Extragastrointestinal manifestations are not rare. A high degree of
clinical suspicion for the disease is needed in atypical cases.
Trimethoprim-sulfamethoxazole is the treatment of choice. We present two
patients with WD. The first presented with melena and generalized
hyperpigmentation. The second had depression for two years before the
typical symptoms. Both hyperpigmentation and long-lasting depression
without the typical manifestations of the disease are rare. Histologic
examination of tissue biopsies was diagnostic for WD. Both patients were
treated successfully with trimethoprim-sulfamethoxazole