4,083 research outputs found
Comment on "Delayed luminescence of biological systems in terms of coherent states" [Phys. Lett. A 293 (2002) 93]
Popp and Yan [F. A. Popp, Y. Yan, Phys. Lett. A 293 (2002) 93] proposed a
model for delayed luminescence based on a single time-dependent coherent state.
We show that the general solution of their model corresponds to a luminescence
that is a linear function of time. Therefore, their model is not compatible
with any measured delayed luminescence. Moreover, the functions that they use
to describe the oscillatory behaviour of delayed luminescence are not solutions
of the coupling equations to be solved.Comment: 2 pages, no figur
Pair HMM based gap statistics for re-evaluation of indels in alignments with affine gap penalties: Extended Version
Although computationally aligning sequence is a crucial step in the vast
majority of comparative genomics studies our understanding of alignment biases
still needs to be improved. To infer true structural or homologous regions
computational alignments need further evaluation. It has been shown that the
accuracy of aligned positions can drop substantially in particular around gaps.
Here we focus on re-evaluation of score-based alignments with affine gap
penalty costs. We exploit their relationships with pair hidden Markov models
and develop efficient algorithms by which to identify gaps which are
significant in terms of length and multiplicity. We evaluate our statistics
with respect to the well-established structural alignments from SABmark and
find that indel reliability substantially increases with their significance in
particular in worst-case twilight zone alignments. This points out that our
statistics can reliably complement other methods which mostly focus on the
reliability of match positions.Comment: 17 pages, 7 figure
Predicting computational reproducibility of data analysis pipelines in large population studies using collaborative filtering
Evaluating the computational reproducibility of data analysis pipelines has
become a critical issue. It is, however, a cumbersome process for analyses that
involve data from large populations of subjects, due to their computational and
storage requirements. We present a method to predict the computational
reproducibility of data analysis pipelines in large population studies. We
formulate the problem as a collaborative filtering process, with constraints on
the construction of the training set. We propose 6 different strategies to
build the training set, which we evaluate on 2 datasets, a synthetic one
modeling a population with a growing number of subject types, and a real one
obtained with neuroinformatics pipelines. Results show that one sampling
method, "Random File Numbers (Uniform)" is able to predict computational
reproducibility with a good accuracy. We also analyze the relevance of
including file and subject biases in the collaborative filtering model. We
conclude that the proposed method is able to speedup reproducibility
evaluations substantially, with a reduced accuracy loss
Psyllium seed may be effective in the treatment of gastroesophageal reflux disease (GERD) in patients with functional constipation
AbstractGERD, return of stomach contents into the esophagus, is one of the most common gastrointestinal disorders in medicine. Its common symptoms are heartburn and acid reflux. Usually, patients with GERD history develop clinical signs such as heartburn accompanied by functional constipation. Omeprazole, a proton pump inhibitor (PPIs), is a drug of choice for GERD but all patients do not respond to the drug and long-term use of these drugs leads to infections. According to the same physiopathology mechanisms of chronic constipation and GERD, improvement of functional constipation may be effective in relieving symptoms of GERD. According to the effectiveness of psyllium seeds in chronic constipation symptoms, it is predicted to be effective in treating GERD in patients with chronic constipation
The structure of colloidosomes with tunable particle density: simulation vs experiment
Colloidosomes are created in the laboratory from a Pickering emulsion of
water droplets in oil. The colloidosomes have approximately the same diameter
and by choosing (hairy) particles of different diameters it is possible to
control the particle density on the droplets. The experiment is performed at
room temperature. The radial distribution function of the assembly of (primary)
particles on the water droplet is measured in the laboratory and in a computer
experiment of a fluid model of particles with pairwise interactions on the
surface of a sphere.Comment: 16 pages, 2 tables, 7 figure
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