Do associated anomalies influence mortality in oesophageal atresia?

published_or_final_versio

Long-term follow-up of childhood duodenal ulcers

published_or_final_versio

Pesticide Leaching Potential In ORD River Irrigation Area, Wa

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

Paediatric liver transplantation at Queen Mary Hospital

Conference Theme: Challenges to specialists in the 21st centurypublished_or_final_versio

Symptoms and Surgical Management of a Distal Choledochal Cyst in a Patient with Pancreas Divisum: Case Report and Review of the Literature

We report the case of a 63-year-old woman who presented with the rare finding of a distal choledochocele in a pancreas divisum with recurrent abdominal pain and episodes of pancreatitis. She underwent successful resection with choledochectomy, papillectomy and reconstruction with a hepatico-jejunostomy and reinsertion of the uncinate pancreatic duct into the same jejunal loop. Comparable literature findings are discussed with regard to the presented case

The RESOLVE Trial for people with chronic low back pain: Statistical analysis plan

Background: Statistical analysis plans describe the planned data management and analysis for clinical trials. This supports transparent reporting and interpretation of clinical trial results. This paper reports the statistical analysis plan for the RESOLVE clinical trial. The RESOLVE trial assigned participants with chronic low back pain to graded sensory-motor precision training or sham-control. Results: We report the planned data management and analysis for the primary and secondary outcomes. The primary outcome is pain intensity at 18-weeks post randomization. We will use mixed-effects models to analyze the primary and secondary outcomes by intention-to-treat. We will report adverse effects in full. We also describe analyses if there is non-adherence to the interventions, data management procedures, and our planned reporting of results. Conclusion: This statistical analysis plan will minimize the potential for bias in the analysis and reporting of results from the RESOLVE trial. Trial registration: ACTRN12615000610538 (https://www.anzctr.org.au/Trial/Registration/ TrialReview.aspx?id=368619). © 2020 Associac¸ao˜ Brasileira de Pesquisa e Pos-Graduac ´ ¸ao˜ em Fisioterapia. Published by Elsevier Editora Ltda. All rights reserved

A fibril-specific, conformation-dependent antibody recognizes a subset of Aβ plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain

Beta-amyloid (Aβ) is thought to be a key contributor to the pathogenesis of Alzheimer disease (AD) in the general population and in adults with Down syndrome (DS). Different assembly states of Aβ have been identified that may be neurotoxic. Aβ oligomers can assemble into soluble prefibrillar oligomers, soluble fibrillar oligomers and insoluble fibrils. Using a novel antibody, OC, recognizing fibrils and soluble fibrillar oligomers, we characterized fibrillar Aβ deposits in AD and DS cases. We further compared human specimens to those obtained from the Tg2576 mouse model of AD. Our results show that accumulation of fibrillar immunoreactivity is significantly increased in AD relative to nondemented aged subjects and those with select cognitive impairments (p < 0.0001). Further, there was a significant correlation between the extent of frontal cortex fibrillar deposit accumulation and dementia severity (MMSE r = −0.72). In DS, we observe an early age of onset and age-dependent accumulation of fibrillar OC immunoreactivity with little pathology in similarly aged non-DS individuals. Tg2576 mice show fibrillar accumulation that can be detected as young as 6 months. Interestingly, fibril-specific immunoreactivity was observed in diffuse, thioflavine S-negative Aβ deposits in addition to more mature neuritic plaques. These results suggest that fibrillar deposits are associated with disease in both AD and in adults with DS and their distribution within early Aβ pathology associated with diffuse plaques and correlation with MMSE suggest that these deposits may not be as benign as previously thought

Hipertensi pada Remaja

Pengukuran tekanan darah saat pemeriksaan kesehatan rutin terhadap remaja akan memungkinkan ditemukannya hipertensi asimptomatik yang signifikan oleh karena penyakit yang tidak diketahui, dan memperkuat pernyataan bahwa sering terjadi kenaikan tekanan darah yang ringan pada remaja. Penyebab hipertensi pada remaja (usia 13-18 tahun) yang paling sering adalah hipertensi esensial (80%), diikuti penyakit ginjal. Hipertensi esensial pada remaja dapat merupakan lanjutan dari masa kanak-kanak dan berlanjut ke masa dewasa. Remaja dengan tekanan darah di atas persentil ke-90 menurut umur memerlukan pemeriksaan berkala. Remaja dengan hipertensi ringan yang asimptomatik hanya memerlukan pemeriksaan yang sederhana. Tujuan tata laksana hipertensi pada remaja, untuk menurunkan tekanan darah di bawah persentil ke-95 dan mencegah komplikasi. Tata laksana ini mencakup non farmakologik dan farmakologi

Tingkat Pengetahuan, Perilaku, dan Kepatuhan Berobat Orangtua dari Pasien Epilepsi Anak di Medan

Latar belakang. Beberapa kepustakaan menyatakan, masih kurang pengetahuan orangtua tentang penyakit epilepsi. Perilaku negatif terhadap anak pasien epilepsi disebabkan karena ketidaktahuan dan kesalahan pengertian terhadap penyakit epilepsi. Tujuan. Mengetahui tingkat pengetahuan, perilaku, dan kepatuhan berobat pada orangtua dari anak pasien epilepsi. Metode. Penelitian merupakan suatu studi deskriptif terhadap 65 orangtua dan pengasuh dari anak pasien epilepsi (usia 0-18 tahun) yang datang ke poliklinik neurologi anak RSUP H. Adam Malik Medan, antara bulan Januari-Maret 2008. Digunakan kuesioner yang terdiri dari 39 pertanyaan yang diisi sendiri oleh orangtua ataupun pengasuh. Hasil. Dari 65 orang responden, 89,2% adalah orangtua dari anak pasien epilepsi. Responden (46,2%) berusia 31-40 tahun, dan 13,8% berpendidikan setingkat universitas. Dari hasil kuesioner yang menilai tingkat pengetahuan didapat 82,5% pernah mendengar tentang epilepsi, tetapi 92,1% di antaranya menjawab masih memerlukan informasi lebih tentang epilepsi. Pada 55,6% responden setuju bahwa epilepsi dapat menyebabkan perubahan perilaku. Mengenai kepatuhan berobat, 79,4% responden secara teratur mendapat obat anti epilepsi. Kesimpulan. Meskipun tingkat kepatuhan berobat cukup baik, tetapi sebagian besar orangtua dan pengasuh dari anak epilepsi pernah mendengar tentang epilepsi tetapi informasi yang didapat masih terbatas. Mereka membutuhkan tambahan informasi tentang penyakit epilepsi dan pengobatannya. Perlu dilakukan program edukasi dan penyebaran informasi pada orangtua dari anak pasien epilepsi dan masyarakat di Medan dan sekitarnya