EVALUATING THE IMPACT OF ENDOCRINE-DISRUPTING CHEMICALS ON FERTILITY IN WILDLIFE: FROM AMPHIBIANS TO MAMMALS

Endocrine-disrupting chemicals are contaminants that interrelate with wildlife's endocrine systems, producing negative influences on reproductive health and growth. Industrial pollutants, medicines and pesticides are between the chemicals that have develop a main source of worry due to of their pervasiveness in the environment and capability to reason ecological damage. This study brings both present data on the effects of EDCs on reproductive health in a diversity of animal species, particularly birds, fish, frogs, and mammals. Amphibians, together their complex life cycles and pored skin are particularly susceptible to EDCs. In relation to studies, contact to chemicals such as atrazine able to damage sexual development, causing in slanted sex proportions and developmental irregularities. Fish, which are significant indicators of marine ecosystem health, exhibition changed sexual development and reproductive disappointments due to of EDCs like estrogenic compounds and PCBs. Birds are harmed via EDCs like DDT, which leading to reproductive failures and eggshell thinning, influencing general population health. Mammals, reaching from little rodents to enormous animals, developmental defects, display lower fertility and behavioral alterations in reply to EDC exposure. Such EDCs clearly and profoundly affect reproductive health via altering gene expression, blocking receptors and mimicking hormones. Studies provide wide-ranging insights for these pathways, while field investigations afford experimental evidence of the effects of EDCs. Bio-monitoring methods, like tissue analysis and health markers, are very important to determining exposure levels and results. Identifying the influence of EDCs on animal reproductive health is significant for conservation initiatives and emerging regulation. Effective regulations might contain limiting the usage of dangerous chemicals and establishing monitoring systems to checked EDC levels in environment and the animals. Conservation efforts must prioritize habitat management and refurbishment because offset the effects of EDCs and safeguard endangered species. This research confirms the requirement for ongoing research and work to address the issues presented via endocrine disruption in animal populations. The research will explore how toxic chemicals disturb nature reproduction via analyzing variations in mating habits, sexual development, and fertility. It will examine how these materials influence hormonal systems via inhibiting receptors and mimicking hormones. Additionally, the research will observe current legislation governing these chemicals, assess their effectiveness, and refer for greater animal protection

EVALUATING THE IMPACT OF ENDOCRINE-DISRUPTING CHEMICALS ON FERTILITY IN WILDLIFE: FROM AMPHIBIANS TO MAMMALS

Endocrine-disrupting chemicals are contaminants that interrelate with wildlife's endocrine systems, producing negative influences on reproductive health and growth. Industrial pollutants, medicines and pesticides are between the chemicals that have develop a main source of worry due to of their pervasiveness in the environment and capability to reason ecological damage. This study brings both present data on the effects of EDCs on reproductive health in a diversity of animal species, particularly birds, fish, frogs, and mammals. Amphibians, together their complex life cycles and pored skin are particularly susceptible to EDCs. In relation to studies, contact to chemicals such as atrazine able to damage sexual development, causing in slanted sex proportions and developmental irregularities. Fish, which are significant indicators of marine ecosystem health, exhibition changed sexual development and reproductive disappointments due to of EDCs like estrogenic compounds and PCBs. Birds are harmed via EDCs like DDT, which leading to reproductive failures and eggshell thinning, influencing general population health. Mammals, reaching from little rodents to enormous animals, developmental defects, display lower fertility and behavioral alterations in reply to EDC exposure. Such EDCs clearly and profoundly affect reproductive health via altering gene expression, blocking receptors and mimicking hormones. Studies provide wide-ranging insights for these pathways, while field investigations afford experimental evidence of the effects of EDCs. Bio-monitoring methods, like tissue analysis and health markers, are very important to determining exposure levels and results. Identifying the influence of EDCs on animal reproductive health is significant for conservation initiatives and emerging regulation. Effective regulations might contain limiting the usage of dangerous chemicals and establishing monitoring systems to checked EDC levels in environment and the animals. Conservation efforts must prioritize habitat management and refurbishment because offset the effects of EDCs and safeguard endangered species. This research confirms the requirement for ongoing research and work to address the issues presented via endocrine disruption in animal populations. The research will explore how toxic chemicals disturb nature reproduction via analyzing variations in mating habits, sexual development, and fertility. It will examine how these materials influence hormonal systems via inhibiting receptors and mimicking hormones. Additionally, the research will observe current legislation governing these chemicals, assess their effectiveness, and refer for greater animal protection

Exploring The Impact of Capecitabine Treatment on Hormonal and Biochemical Markers in Women with Breast Cancer

Cancer antigen 15-3 (CA15-3) is a widely used tumor marker, and the serum level of this tumor marker is measured periodically in breast cancer patients during the chemotherapy period by capecitabine , Assuming that the higher serum levels of this tumor marker can be a potential risk in breast cancer patients, the study aimed to examine the effect on  capecitabine with Ca15.3, serum estradiol, and calcium levels in postmenopausal women with breast cancer. The study was conducted on a total of 200 women, including 100 women without breast cancer who served as a control group aged range from (45-75years) and 100 women with breast cancer whose ages ranged from (40-70years). Patients at the oncology center at Imam al-Hussain medical city in Kerbala, Iraq, were sorted into groups based on their age, body mass index, disease duration, and treatment length for this study, which was done between July 2022 and October 2022, the efficacy of capecitabine, the plasma levels of (estradiol, Ca 15.3, and calcium) were measured in 100 breast cancer patients who had been taking the drug for at least 3 months. The findings revealed a statistically significant increase (p 0.05) in the concentration of Ca15.3 levels in women with breast cancer compared with control group, breast cancer (BC) is the most common form of cancer that results, and the average levels of serum calcium and estradiol were increased in patient had breast cancer chemotherapy and different with normal range, otherwise, the average level of serum calcium and estradiol in control groups within the normal range.in conclusion According to the ca15.3,serum calcium and estradiol levels, The high stability and existence of Ca15.3, serum calcium and estradiol in body serum make them a promising new diagnostic biomarker for breast cancer patients