3 research outputs found
Iron deficiency in pregnant women suffering from chronic pyelonephritis
The aim of the study was the assessment of the peculiarities of iron metabolism in pregnant women suffering from chronic pyelonephritis. There was shown that pregnant females have signs of iron deficiency anemia which is more severe in women suffering from chronic pyelonephritis. The iIncidence of chronic pyelonephritis in women with signs of syderopenic syndrome is 35.0 %. There is discussed the pathogenesis of iron deficiency related to the renal dysfunction
Π€Π΅Π½ΠΎΠΌΠ΅Π½ Π²Π·Π°ΠΈΠΌΠ½ΠΎΠ³ΠΎ ΠΎΡΡΠ³ΠΎΡΠ΅Π½ΠΈΡ ΠΏΡΠΈ ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ ΠΆΠ΅Π»Π΅Π·ΠΎΠ΄Π΅ΡΠΈΡΠΈΡΠ½ΠΎΠΉ Π°Π½Π΅ΠΌΠΈΠΈ ΠΈ Ρ ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠΎΠ³Π΅Π½ΠΈΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ Ρ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΠ΅ΡΠΎΡ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Π±ΡΠ»Π° ΠΎΡΡΠ½ΠΊΠ° ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΠ΅ΠΉ ΠΊΠ»ΡΠ½ΡΡΠ½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠ΅Π±ΡΠ³Ρ Π·Π°Π»ΡΠ·ΠΎΠ΄Π΅ΡΡΡΠΈΡΠ½ΠΎΡ Π°Π½Π΅ΠΌΡΡ Ρ Π²Π°Π³ΡΡΠ½ΠΈΡ
Π· Ρ
ΡΠΎΠ½ΡΡΠ½ΠΎΡ ΡΡΠΎΠ³Π΅Π½ΡΡΠ°Π»ΡΠ½ΠΎΡ ΡΠ½ΡΠ΅ΠΊΡΡΡΡ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΠΎ ΠΏΡΠΈ ΡΠΏΠΎΠ»ΡΡΠ΅Π½Π½Ρ Ρ
ΡΠΎΠ½ΡΡΠ½ΠΎΡ ΡΡΠΎΠ³Π΅Π½ΡΡΠ°Π»ΡΠ½ΠΎΡ ΡΠ½ΡΠ΅ΠΊΡΡΡ ΡΠ° Π·Π°Π»ΡΠ·ΠΎΠ΄Π΅ΡΡΡΠΈΡΠ½ΠΎΡ Π°Π½Π΅ΠΌΡΡ ΡΠ΅Π°Π»ΡΠ·ΡΡΡΡΡΡ ΡΠ΅Π½ΠΎΠΌΠ΅Π½ Π²Π·Π°ΡΠΌΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΡΠΆΠ΅Π½Π½Ρ. Π£ Π²Π°Π³ΡΡΠ½ΠΈΡ
Π· ΡΡΠ½ΡΡΠΎΠΏΡΠ΅Ρ Ρ
ΡΠΎΠ½ΡΡΠ½ΠΎΠ³ΠΎ ΠΏΡΡΠ»ΠΎΠ½Π΅ΡΡΠΈΡΡ ΡΠ° ΡΡΠ΄Π΅ΡΠΎΠΏΠ΅Π½ΡΡΠ½ΠΈΡ
ΡΡΠ°Π½ΡΠ² ΠΌΠ°Ρ ΠΌΡΡΡΠ΅ Π²Π½ΡΡΡΡΡΠ½ΡΠΎΠΊΠ»ΡΡΠΈΠ½Π½ΠΈ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΡΡΠ½ΠΈΠΉ Π°ΡΠΈΠ΄ΠΎΠ· Π½Π° ΡΠ»Ρ Π°ΠΊΡΠΈΠ²Π°ΡΡΡ ΠΏΠ΅ΡΠ΅ΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½Π½Ρ Π»ΡΠΏΡΠ΄ΡΠ². ΠΠ°ΡΠ²Π½ΡΡΡΡ Ρ
ΡΠΎΠ½ΡΡΠ½ΠΎΠ³ΠΎ ΠΏΡΡΠ»ΠΎΠ½Π΅ΡΡΠΈΡΡ ΠΏΡΠΈΠ·Π²ΠΎΠ΄ΠΈΠ»Π° Π΄ΠΎ ΠΏΠΎΠ³Π»ΠΈΠ±Π»Π΅Π½Π½Ρ Π΄Π΅ΡΡΡΠΈΡΡ ΡΠΈΡΠΎΠ²Π°ΡΠΊΠΎΠ²ΠΎΠ³ΠΎ Π·Π°Π»ΡΠ·Π° Π΄ΠΎ 8,8 Β± 0,7 ΠΌΠΊΠΌΠΎΠ»Ρ / Π» ΠΏΡΠΈ Π²ΠΌΡΡΡΡ ΡΠ΅ΡΠΈΡΠΈΠ½Ρ Π½Π° ΡΡΠ²Π½Ρ 7,2 Β± 0,2 ΠΌΠΊΠ³ / Π»The aim of the study was to evaluate the characteristics of clinical course of iron deficiency anemia in
pregnant women with chronic urogenital infections.
The survey was conducted at the Regional Clinical Maternity Hospital (Odessa, Ukriane) for 2005-2012 years.
Study involved 100 pregnant women with signs of iron deficiency anemia.
The total array was examined in three clinical groups: patients with verified urogenital infections (n = 50), patients
with chronic pyelonephritis (n = 50). The average age of the patients was 27.1 Β± 1.3 years. The control group
consisted of 30 women with physiological pregnancy in the same age group. All women were examined according
to the order of Ministry of Health of Ukraine from 03.11.2008 ΒΉ 62.
It is shown that with a combination of chronic urogenital infection and iron deficiency anemia implemented
phenomenon of the mutual encumbrance. The growth of microorganisms was observed in 78. 0 % of patients of I
group, 66.0 % of II group and only in 6.7 % cases in the control group. Vaginitis and cervicitis with mixed bacterial
etiology were found in 74.0 % of patients of the first group, and in 42.0 % of women β in the second group. Bacterial
vaginosis was found a quarter of pregnant women with chronic pyelonephritis and iron-deficiency anemia and every
third patient suffered from these conditions in the first group. In all groups examination noteworthy high frequency
of vaginal dysbiosis, which is confirmed by the absence or low content (less than 1000 cfu / ml) of Lactobacilli.
In pregnant women with chronic pyelonephritis and syntropiΓ± syderopenic states there is an intracellular
metabolic acidosis in the background activation of lipid peroxidation. Thus, the activity of antioxidant enzymes in
erythrocytes of women with sideropenicstates was changed. There was found that superoxydysmutaze activity in
red blood cells in peripheral blood of pregnant women was decreased by an average of 15-20 % compared with the
data obtained in the control group. The activity of glutathione peroxidase in red blood cells of women with chronic
pyelonephritis increased by 1.5 folds. These changes were accompanied by an increase in lipid peroxidation activity,
leading to accumulation of lipid peroxidation products in plasma.
There is discussed the an association of this pathological condition with inflammatory diseases of the urinary
tract in pregnant women suffering from iron deficiency anemia, which could lead to complicated pregnancy.
In assessing hematological parameters revealed that among the surveyed pregnant women dominated light and
subclinical forms of IDA. Most main group patients experienced a decline in hemoglobin and red blood cells. Initial
level of iron in serum ranged from 5.3 to 13.3 mmol / l (9,7 Β± 0,9 mmol / l β in the first group, 9,5 Β± 1,1 mmol / l β in
the second group. hemoglobin level ranged from 95 to 135 g / l (113,3 Β± 3,5 g / l β in the first group, 110,5 Β± 3,8 g /
l β in the second group). Red blood cells count was averaged 3 5 1012 / l in pregnant and groups, 3,3 Β± 0,2 1012 / l in
the second group. Hence, patients with IDA hematological parameters practically did not depend on the pattern of
chronic urogenital infection, but the variance of the indicators was slightly higher in pregnant women suffering from
chronic pyelonephritis.
The presence of chronic pyelonephritis led to a deepening deficit of serum iron to 8,8 Β± 0,7 mmol / l in ferritin
content at 7,2 Β± 0,2 mg / l.Π¦Π΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π±ΡΠ»Π° ΠΎΡΠ΅Π½ΠΊΠ° ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΆΠ΅Π»Π΅Π·ΠΎΠ΄Π΅ΡΠΈΡΠΈΡΠ½ΠΎΠΉ Π°Π½Π΅ΠΌΠΈΠΈ Ρ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
Ρ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠΎΠ³Π΅Π½ΠΈΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠ΅ΠΉ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΏΡΠΈ ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠΎΠ³Π΅Π½ΠΈΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ ΠΈ ΠΆΠ΅Π»Π΅Π·ΠΎΠ΄Π΅ΡΠΈΡΠΈΡΠ½ΠΎΠΉ Π°Π½Π΅ΠΌΠΈΠΈ ΡΠ΅Π°Π»ΠΈΠ·ΡΠ΅ΡΡΡ ΡΠ΅Π½ΠΎΠΌΠ΅Π½ Π²Π·Π°ΠΈΠΌΠ½ΠΎΠ³ΠΎ ΠΎΡΡΠ³ΠΎΡΠ΅Π½ΠΈΡ. Π£ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
Ρ ΡΠΈΠ½ΡΡΠΎΠΏΠΈΠ΅Ρ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΈΠ΅Π»ΠΎΠ½Π΅ΡΡΠΈΡΠ° ΠΈ ΡΠΈΠ΄Π΅ΡΠΎΠΏΠ΅Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΡΡΠΎΡΠ½ΠΈΠΉ ΠΈΠΌΠ΅Π΅Ρ ΠΌΠ΅ΡΡΠΎ Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°ΡΠΈΠ΄ΠΎΠ· Π½Π° ΡΠΎΠ½Π΅ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ ΠΏΠ΅ΡΠ΅ΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ². ΠΠ°Π»ΠΈΡΠΈΠ΅ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΠΈΠ΅Π»ΠΎΠ½Π΅ΡΡΠΈΡΠ° ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΠ»ΠΎ ΠΊ ΡΠ³Π»ΡΠ±Π»Π΅Π½ΠΈΡ Π΄Π΅ΡΠΈΡΠΈΡΠ° ΡΡΠ²ΠΎΡΠΎΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΆΠ΅Π»Π΅Π·Π° Π΄ΠΎ 8,8Β±0,7 ΠΌΠΊΠΌΠΎΠ»Ρ / Π» ΠΏΡΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠΈ ΡΠ΅ΡΡΠΈΡΠΈΠ½Π° Π½Π° ΡΡΠΎΠ²Π½Π΅ 7,2Β±0,2 ΠΌΠΊΠ³ / Π»