23 research outputs found
PALEOECOLOGY AND FUNCTIONAL MORPHOLOGY OF THE PERMIAN LYTTONIID BRACHIOPOD PIRGULIA
The lyttoniid brachiopods of the Permian exhibit a unique valve morphology: a branched lobate structure takes the form of the dorsal valve. In one group of lyttoniids, the genus Pirgulia, the ventral valve wraps around to form a cone that fully encloses the lobate structure. This has consequences for the dynamics of water flow and mode of life possible for these heteromorphic brachiopods. Here, we describe the skeletal microstructure and morphology of Pirgulia collected from the Upper Permian Sosio Limestone megablocks of Sicily and housed at the Yale Peabody Museum. We reconstruct the paleoecology of Pirgulia, characterizing it as semi-infaunal in soft sediment. By analogy to Richthofenia, the conical ventral valve and flapping dorsal valve functional morphology could have resisted fouling and assisted feeding in this environment. By comparison with the functional morphology of Pirgulia with other lyttoniids and richthofenids, we propose a revised mode of life for this genus, which involves adaptation to secondary soft-bottom substrates and support by sediment sticking. Despite constraints to the fundamental brachiopod body plan, modification of the valves in Pirgulia to achieve a conical morphology allowed it to inhabit a paleoecological niche distinct from that of other reef-building lyttoniids
A Multicenter Randomized Clinical Trial Evaluating Interleukin-2 Activated Hematopoietic Stem Cell Transplantation and Post-transplant IL-2 for High Risk Breast Cancer Patients
This Phase III randomized multicenter trial compared progression-free (PFS) and overall survival (OS) for autologous peripheral blood stem cell (aPBSC) transplantation with or without immunotherapy in high-risk breast cancer patients.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44232/1/10549_2005_Article_4445.pd
Lenalidomide after Stem-Cell Transplantation for Multiple Myeloma
Data are lacking on whether lenalidomide maintenance therapy prolongs the time to disease progression after autologous hematopoietic stem-cell transplantation in patients with multiple myeloma