3,725 research outputs found
Evolution of transport properties of BaFe2-xRuxAs2 in a wide range of isovalent Ru substitution
The effects of isovalent Ru substitution at the Fe sites of BaFe2-xRuxAs2 are
investigated by measuring resistivity and Hall coefficient on high-quality
single crystals in a wide range of doping (0 < x < 1.4). Ru substitution
weakens the antiferromagnetic (AFM) order, inducing superconductivity for
relatively high doping level of 0.4 < x < 0.9. Near the AFM phase boundary, the
transport properties show non-Fermi-liquid-like behaviors with a
linear-temperature dependence of resistivity and a strong temperature
dependence of Hall coefficient with a sign change. Upon higher doping, however,
both of them recover conventional Fermi-liquid behaviors. Strong doping
dependence of Hall coefficient together with a small magnetoresistance suggest
that the anomalous transport properties can be explained in terms of
anisotropic charge carrier scattering due to interband AFM fluctuations rather
than a conventional multi-band scenario.Comment: 7 pages, 6 figures, submitted to Phys. Rev.
A prospective multiple case study of the impact of emerging scientific evidence on established colorectal cancer screening programs: a study protocol.
BackgroundHealth-policy decision making is a complex and dynamic process, for which strong evidentiary support is required. This includes scientifically produced research, as well as information that relates to the context in which the decision takes place. Unlike scientific evidence, this "contextual evidence" is highly variable and often includes information that is not scientifically produced, drawn from sources such as political judgement, program management experience and knowledge, or public values. As the policy decision-making process is variable and difficult to evaluate, it is often unclear how this heterogeneous evidence is identified and incorporated into "evidence-based policy" decisions. Population-based colorectal cancer screening poses an ideal context in which to examine these issues. In Canada, colorectal cancer screening programs have been established in several provinces over the past five years, based on the fecal occult blood test (FOBT) or the fecal immunochemical test. However, as these programs develop, new scientific evidence for screening continues to emerge. Recently published randomized controlled trials suggest that the use of flexible sigmoidoscopy for population-based screening may pose a greater reduction in mortality than the FOBT. This raises the important question of how policy makers will address this evidence, given that screening programs are being established or are already in place. This study will examine these issues prospectively and will focus on how policy makers monitor emerging scientific evidence and how both scientific and contextual evidence are identified and applied for decisions about health system improvement.MethodsThis study will employ a prospective multiple case study design, involving participants from Ontario, Alberta, Manitoba, Nova Scotia, and Quebec. In each province, data will be collected via document analysis and key informant interviews. Documents will include policy briefs, reports, meeting minutes, media releases, and correspondence. Interviews will be conducted in person with senior administrative leaders, government officials, screening experts, and high-level cancer system stakeholders.DiscussionThe proposed study comprises the third and final phase of an Emerging Team grant to address the challenges of health-policy decision making and colorectal cancer screening decisions in Canada. This study will contribute a unique prospective look at how policy makers address new, emerging scientific evidence in several different policy environments and at different stages of program planning and implementation. Findings will provide important insight into the various approaches that are or should be used to monitor emerging evidence, the relative importance of scientific versus contextual evidence for decision making, and the tools and processes that may be important to support challenging health-policy decisions
PCN58 IS CYP2D6 GENETIC TEST IN COMBINATION WITH HORMONE THERAPY FOR ER+ HORMONE SENSITIVE WOMEN WITH EARLY BREAST CANCER COST-EFFECTIVE?
PND9 IS GENETIC TESTING IN COMBINATION WITH PREVENTIVE DONEPEZIL (ARICEPT®) TREATMENT FOR PATIENTS WITH MILD COGNITIVE IMPAIRMENT COST- EFFECTIVE?
Fiber-Cavity-Based Optomechanical Device
We describe an optomechanical device consisting of a fiber-based optical
cavity containing a silicon nitiride membrane. In comparison with typical
free-space cavities, the fiber-cavity's small mode size (10 {\mu}m waist, 80
{\mu}m length) allows the use of smaller, lighter membranes and increases the
cavity-membrane linear coupling to 3 GHz/nm and quadratic coupling to 20
GHz/nm^2. This device is also intrinsically fiber-coupled and uses glass
ferrules for passive alignment. These improvements will greatly simplify the
use of optomechanical systems, particularly in cryogenic settings. At room
temperature, we expect these devices to be able to detect the shot noise of
radiation pressure.Comment: 4 pages, 3 figures; the following article has been submitted to
Applied Physics Letter
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