Human parvovirus 4 'PARV4' remains elusive despite a decade of study

Human parvovirus 4 ('PARV4') is a small DNA tetraparvovirus, first reported in 2005. In some populations, PARV4 infection is uncommon, and evidence of exposure is found only in individuals with risk factors for parenteral infection who are infected with other blood-borne viruses. In other settings, seroprevalence studies suggest an endemic, age-associated transmission pattern, independent of any specific risk factors. The clinical impact of PARV4 infection remains uncertain, but reported disease associations include an influenza-like syndrome, encephalitis, acceleration of HIV disease, and foetal hydrops. In this review, we set out to report progress updates from the recent literature, focusing on the investigation of cohorts in different geographical settings, now including insights from Asia, the Middle East, and South America, and discussing whether attributes of viral or host populations underpin the striking differences in epidemiology. We review progress in understanding viral phylogeny and biology, approaches to diagnostics, and insights that might be gained from studies of closely related animal pathogens. Crucial questions about pathogenicity remain unanswered, but we highlight new evidence supporting a possible link between PARV4 and an encephalitis syndrome. The unequivocal evidence that PARV4 is endemic in certain populations should drive ongoing research efforts to understand risk factors and routes of transmission and to gain new insights into the impact of this virus on human health

First report of human parvovirus 4 detection in Iran

Parvovirus 4 (PARV4) is an emerging and intriguing virus that currently received many attentions. High prevalence of PARV4 infection in high-risk groups such as HIV infected patients highlights the potential clinical outcomes that this virus might have. Molecular techniques were used to determine both the presence and the genotype of circulating PARV4 on previously collected serum samples from 133 HIV infected patients and 120 healthy blood donors. Nested PCR was applied to assess the presence of PARV4 DNA genome in both groups. PARV4 DNA was detected in 35.3 of HIV infected patients compared to 16.6 healthy donors. To genetically characterize the PARV4 genotype in these groups, positive samples were randomly selected and subjected for sequencing and phylogenetic analysis. All PARV4 sequences were found to be genotype 1 and clustered with the reference sequences of PARV4 genotype 1. © 2016 Wiley Periodicals, Inc

Ocean Remote Sensing Techniques and Applications: A Review (Part I)

Oceans cover over 70% of the Earth’s surface and provide numerous services to humans and the environment. Therefore, it is crucial to monitor these valuable assets using advanced technologies. In this regard, Remote Sensing (RS) provides a great opportunity to study different oceanographic parameters using archived consistent multitemporal datasets in a cost-efficient approach. So far, various types of RS techniques have been developed and utilized for different oceanographic applications. In this study, 15 applications of RS in the ocean using different RS techniques and systems are comprehensively reviewed and discussed. This study is divided into two parts to supply more detailed information about each application. The first part briefly discusses 12 different RS systems that are often employed for ocean studies. Then, six applications of these systems in the ocean, including Ocean Surface Wind (OSW), Ocean Surface Current (OSC), Ocean Wave Height (OWH), Sea Level (SL), Ocean Tide (OT), and Ship Detection (SD), are provided. For each application, the applicable RS systems, their advantages and disadvantages, various RS and Machine Learning (ML) techniques, and several case studies are discussed. The other nine applications, including Iceberg, Sea Ice (SI), Sea Surface temperature (SST), Ocean Surface Salinity (OSS), Ocean Color (OC), Ocean Chlorophyll (OCh), Ocean Oil Spill (OOS), Underwater Ocean, and Fishery, are provided in Part II of this study